Results 31 to 40 of about 3,231,427 (376)

Towards the development of new subtype-specific muscarinic receptor radiopharmaceuticals-radiosynthesis and ex vivo biodistribution of [18F] 3-(4-(2-(2-(2-fluoroethoxy) ethoxy) ethylthio)-1, 2, 5-thiadiazol-3-yl)-1-methyl-1, 2, 5, 6-tetrahydropyridine [PDF]

, 2010
Muscarinic receptors have been implicated in neurological disorders including Alzheimer’s disease, Parkinson’s disease, and schizophrenia. Nineteen derivatives of thiadiazolyltetrahydropyridine (TZTP), a core that has previously shown high affinities ...
Houle, Sylvain, Mamo, David, Mulsant, Benoit H., Pollock, Bruce G., van Oosten, Erik M., Vasdev, Neil, Wilson, Alan A.   +6 more
core   +1 more source

Fully Automated GMP-Compliant Synthesis of [¹⁸F]FE-PE2I

Pharmaceuticals, 2021
In the struggle to understand and accurately diagnose Parkinson′s disease, radiopharmaceuticals and medical imaging techniques have played a major role. By being able to image and quantify the dopamine transporter density, noninvasive diagnostic imaging ...
Klas Bratteby, Charlotte Lund Denholt, Szabolcs Lehel, Ida Nymann Petersen, Jacob Madsen, Maria Erlandsson, Tomas Ohlsson, Matthias Manfred Herth, Nic Gillings   +8 more
doaj   +1 more source

Positron emission tomography in the diagnosis and follow-up of transthyretin amyloid cardiomyopathy patients:A systematic review [PDF]

, 2023
Purpose: Transthyretin (ATTR) amyloidosis is a progressive protein misfolding disease with frequent cardiac involvement. This review aims to determine the value of PET in diagnosis, assessment of disease progression or treatment response and its relation
Nienhuis, H. L.A., Pastoor, E. M., Slart, R. H.J.A., Tingen, H. S.A., Tubben, A., van der Meer, P., van Zon, P. P.A., van ’t Oever, J. H.   +7 more
core   +4 more sources

Fluorine-18 labelled building blocks for PET tracer synthesis.

Chemical Society Reviews, 2017
Positron emission tomography (PET) is an important driver for present day healthcare. Fluorine-18 is the most widely used radioisotope for PET imaging and a thorough overview of the available radiochemistry methodology is a prerequisite for selection of ...
Dion van der Born, A. Pees, A. Poot, R. Orru, A. Windhorst, D. Vugts   +5 more
semanticscholar   +1 more source

Prognostic role of preoperative fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography with an image-based harmonization technique: A multicenter retrospective studyCentral MessagePerspective

JTCVS Open, 2023
Objectives: Despite the prognostic impacts of preoperative fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography examination, fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography–based prognosis ...
Akira Hamada, MD, PhD, Kazuhiro Kitajima, MD, PhD, Kenichi Suda, MD, PhD, Takamasa Koga, MD, PhD, Junichi Soh, MD, PhD, Hayato Kaida, MD, PhD, Kimiteru Ito, MD, PhD, Tetsuro Sekine, MD, PhD, Kyoshiro Takegahara, MD, PhD, Hiromitsu Daisaki, PhD, Masaki Hashimoto, MD, PhD, Yukihiro Yoshida, MD, PhD, Takanobu Kabasawa, MD, PhD, Takashi Yamasaki, MD, Seiichi Hirota, MD, PhD, Jitsuo Usuda, MD, PhD, Kazunari Ishii, MD, PhD, Tetsuya Mitsudomi, MD, PhD   +17 more
doaj  

Radiosynthesis of [¹⁸F]-Labelled Pro-Nucleotides (ProTides)

Molecules, 2020
Phosphoramidate pro-nucleotides (ProTides) have revolutionized the field of anti-viral and anti-cancer nucleoside therapy, overcoming the major limitations of nucleoside therapies and achieving clinical and commercial success.
Alessandra Cavaliere, Katrin C. Probst, Stephen J. Paisey, Christopher Marshall, Abdul K. H. Dheere, Franklin Aigbirhio, Christopher McGuigan, Andrew D. Westwell   +7 more
doaj   +1 more source

Carbon-11 and Fluorine-18 Labeled Amino Acid Tracers for Positron Emission Tomography Imaging of Tumors

Frontiers in Chemistry, 2018
Tumor cells have an increased nutritional demand for amino acids (AAs) to satisfy their rapid proliferation. Positron-emitting nuclide labeled AAs are interesting probes and are of great importance for imaging tumors using positron emission tomography ...
Aixia Sun, Xiang Liu, Ganghua Tang
semanticscholar   +1 more source

Fluorine-18: an untapped resource in inorganic chemistry [PDF]

Chemical Communications, 2018
Advances in the field of fluorine chemistry have been applied extensively to the syntheses of 18F-labelled organic compounds and radiopharmaceuticals.
Cassis Varlow, Cassis Varlow, Vadim Bernard-Gauthier, Vadim Bernard-Gauthier, Neil Vasdev, Neil Vasdev, Kenneth Dahl, Kenneth Dahl, Daniel Szames, Daniel Szames   +9 more
openaire   +3 more sources

A New Method for 18FDG generating using Geant4/ Gate7

Basic & Clinical Cancer Research, 2023
Fluorine 18-deoxyglucose is often used in Positron Emission Tomography devices. Positron Emission Tomography imaging is one of the useful tools which is used for cancer detection and its management.
Abuzar Shakeri, Ebrahim Heidari, Seyedeh Nasrin Hosseini Motlagh, Hamid Reza Vanaei   +3 more
doaj  

Dry Small Pleural Dissemination of Adenocarcinoma of the Lung Preoperatively Detected by PET/CT: A Report of Two Cases [PDF]

, 2008
Dry pleural dissemination in non-small cell lung cancer, defined as solid pleural metastasis of lung cancer without pleural eff usion, is a condition occurring in T4 lung cancer.
Aoe, Motoi, Date, Hiroshi, Okutani, Daisuke, Oto, Takahiro, Sano, Yoshifumi, Toyooka, Shinichi, Yamane, Masaomi   +6 more
core   +1 more source