Results 61 to 70 of about 45,567 (210)

Spatiotemporally Controlled Sequential Chemo‐Immunotherapy Activates Pyroptosis for Robust Anti‐Tumor Immunotherapy

Advanced Science, EarlyView.
A glutathione and ultrasound dual‐responsive cerasome achieves sequential co‐delivery of gemcitabine and BMS1166 in tumors. Chemotherapy priming followed by on‐demand PD‐L1 blockade synergistically amplifies anti‐tumor immunity, inhibiting primary tumor growth, distant metastasis and inducing durable immune memory.
Suhui Sun, Ruiqi Wu, Qingshuang Tang, Yunli Xu, Wanrui Shi, Mengxin Wang, Haonan Wang, Yan Luo, Cheng Ma, Xiaolong Liang   +9 more
wiley   +1 more source

Chromosomal differentiation among bisexual European species of Saga (Orthoptera: Tettigoniidae: Saginae) detected by both classical and molecular methods

European Journal of Entomology, 2009
We report the karyotype characteristics including chromosome numbers of Saga campbelli campbelli, S. c. gracilis, and S. rammei using the following classical cytogenetic methods: C-banding, silver staining, and fluorochrome staining DAPI and CMA3.
Elżbieta WARCHAŁOWSKA-ŚLIWA, Beata GRZYWACZ, Anna MARYAŃSKA-NADACHOWSKA, Tatjana V. KARAMYSHEVA, Nikolai B. RUBTSOV, Dragan P. CHOBANOV   +5 more
doaj   +1 more source

Magnetically Guided Macrophage Immunobots Coordinate Iron‐Metabolic Cascades and Immunogenic Ferroptosis for Tumor Immunotherapy

Advanced Science, EarlyView.
Magnetically guided macrophage immunobots integrate active tumor targeting with immunometabolic therapy. After systemic administration, magnetic actuation enhances immunobot retention and tumor penetration, while LPS‐functionalized FePt microrollers sustain M1‐like polarization through inflammatory and iron‐amplified oxidative signaling and trigger ...
Xirui Zeng, Yingfei Zhang, Chong Wu, Qijia Duan, Mengqi Fan, Kuan Wang, Shirong Cai, Immihan Ceren Yasa   +7 more
wiley   +1 more source

Do myelomatous plasma cells really express surface immunoglobulins?

Haematologica, 1996
Surface immunoglobulins (sIg) are traditionally considered to be absent in plasma cells (PC). However, it has recently been reported that up to one third of myeloma patients are positive for surface immunoglobulins. Nevertheless, this observation has not
M Ocqueteau, JF San Miguel, M Gonzalez, J Almeida, A Orfao   +4 more
doaj  

SIMPLE AND RAPID STAINING FOR DETECTION OF ENTAMOEBA CYSTS AND OTHER PROTOZOANS WITH FLUOROCHROMES

Japanese Journal of Medical Science and Biology, 1987
Three fluorochromes were applied to stain various parasitic protozoans. By double staining with 4',6-diamidino-2-phenylindole and propidium iodide, differentiation of the nuclei from the cytoplasm can easily be achieved within several seconds. The chromatoid bodies in Entamoeba cysts were stained bright red.
KAWAMOTO, Fumihiko, MIZUNO, Sahoko, FUJIOKA, Hisashi, KUMADA, Nobuo, SUGIYAMA, Etsuro, TAKEUCHI, Tsutomu, KOBAYASHI, Seiki, ISEKI, Motohiro, YAMADA, Minoru, MATSUMOTO, Yoshitsugu, TEGOSHI, Tatsuya, YOSHIDA, Yukio   +11 more
openaire   +3 more sources

A Tumor‐Boundary Niche Enriched for PD‐1+CD8+T Cells and BTLA+B Cells Drives Resistance to Immunotherapy in NSCLC

Advanced Science, EarlyView.
A spatial niche composed of BTLA+B cells and CD8+T cells is enriched at the tumor boundary in non‐small cell lung cancer. Within this specialized niche, BTLA+B cells act as a dominant source of IL‐6, upregulating PD‐1 on CD8+T cells via STAT3 signaling.
Jiajuan Wu, Shiying Guo, Leilei Lv, Guiqin Fan, Yu Shen, Qiuxia Qu, Cheng Chen   +6 more
wiley   +1 more source

Cytogenetic studies in six species of Scinax (Anura, Hylidae) clade Scinax ruber from northern and northeastern Brazil

Genetics and Molecular Biology, 2015
Scinax species are still underrepresented in cytogenetic studies, mainly with respect to populations from northeastern and northern Brazil. In this study, we provide new chromosomal information on Scinax boesemani, S. camposseabrai, S.
Lídia Nogueira, Juliani Bruna Zanoni, Mirco Solé, Paulo Roberto Antunes de Mello Affonso, Sérgio Siqueira, Iracilda Sampaio   +5 more
doaj   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

Enhanced detection of bacteria in natural environments by fluorochrome staining of DNA1 [PDF]

Limnology and Oceanography, 1980
The DNA‐staining fluorochromes 4′6‐diamidino‐2‐phenylindole (DAPI) and mithramycin, when used in conjunction with epi‐illumination fluorescence microscopy, readily reveal the presence of bacteria, thus simplifying the detection of bacterial contaminants in allegedly axenic laboratory cultures of eucaryote cells.
openaire   +1 more source

Platycodon grandiflorus–Derived Nanovesicles Sensitize Gastric Cancer to T Cell Killing via Ferroptosis‐Driven Membrane Mechanical Remodeling

Advanced Science, EarlyView.
Plant‐derived nanovesicles from Platycodon grandiflorus act as bioactive lipid delivery platforms that transport γ‐linolenic acid into gastric cancer cells. This lipid cargo promotes ferroptotic lipid peroxidation, remodels membrane mechanics, and increases tumor‐cell susceptibility to cytotoxic T‐cell attack.
Jian Wu, Ruijuan Zhang, Yixin Duan, Shuqi Huo, Xiang Zhang, Yibin Xing, Lingjing Ma, Tiran Jiang, Xingyu Chen, Qingmin Sun   +9 more
wiley   +1 more source