Results 141 to 150 of about 17,088 (300)

Looking at Soil as It Is: Evolution of Microscopic Soil Characterization From Kubiëna to Artificial Intelligence

Journal of Plant Nutrition and Soil Science, EarlyView.
We provide a historic overview of microscopic soil structure characterization from its founding father, Walter Kubiëna, to several technical revolutions like automation, digitalization, and artificial intelligence. In addition to technical advancements, we explore how concepts and research questions have evolved in time.
Steffen Schlüter, Maik Geers‐Lucas, Peter Kühn, Hans‐Jörg Vogel   +3 more
wiley   +1 more source

To fret over FRET: Unintended fluorescence energy transfer artifacts and their implications for flow cytometry panel design and interpretation as highlighted by TRBC1/2 assays. [PDF]

Cytometry B Clin Cytom
Wang HW, Delgado Colon D, Murphy K, Sochacki RR, Honec R, Wellek J, Bristol I, Jang J, Ho T, Monreal M, Yuan CM.   +10 more
europepmc   +1 more source

SERPINB9 Promotes Colorectal Cancer Liver Metastasis and Immunotherapy Resistance: Association With MHC‐I Downregulation and CD8+ T Cell Dysfunction

Medicine Bulletin, EarlyView.
ABSTRACT Background Colorectal cancer liver metastasis (CRLM) is the leading cause of mortality in colorectal cancer (CRC) patients, for which effective treatments remain limited. The mechanisms by which tumor cells evade immune surveillance and escape cytotoxic killing remain poorly understood.
Xin Liu, Wenchen Wang, Hongqian Wang, Yanshen Kuang, Baoqing Jia   +4 more
wiley   +1 more source

A Clinically Applicable Unmixing Approach for Spectral MRD Detection in AML. [PDF]

Cancers (Basel)
Waclawski JP, Arnhardt I, Fokken H, Kattre N, den Hartog D, Snel AN, Kelder A, Herbst J, Sauer MG, Stadler M, Heuser M, Bachas C, Schwarzer A, Maetzig T.   +13 more
europepmc   +1 more source

HER2‐Targeted AIE Nanotheranostics Overcome SHR‐A1811 Resistance via Immunogenic Pyroptosis and Tumor‐Associated Macrophage Reprogramming in Breast Cancer

Small, EarlyView.
HER2‐targeted AIE780‐A1811 nanoparticles self‐assemble via amide coupling of a mitochondria‐directed photosensitizer with the ADC SHR‐A1811. Upon 660 nm irradiation, they generate ROS, photothermal effects, and controlled drug release, inducing immunogenic pyroptosis and M2‐to‐M1 macrophage reprogramming. This dual action remodels the immunosuppressive
Xiaohong Liu, Nisha Wu, Zaihui Peng, Guozhi Zhang, Lin Ren, Qiuyun Li, Jie Xiao, Jing He, Yuxiuzi Xiao, Li Ma, Yi Zhang, Ying Gong, Xiaowei Qi   +12 more
wiley   +1 more source

In-situ competition between protamine and fluorochromes for sperm DNA

, 1998
In this study we investigated the relationship between the presence of bound protamine on mouse and human sperm DNA and the level of chromomycin A(3) (CMA(3)) and 4'6-diamidino-2-phenylindole (DAPI) fluorescence.
BIZZARO, Davide, MANICARDI G. C., BIZZARO D, G. MANICARDI, SAKKAS D, MARIETHOZ E., BIANCHI P. G., BIANCHI P. G, Mariethoz E, BIANCHI U, SAKKAS D.   +10 more
core  

A standardized single-tube 17-color spectral flow cytometry workflow for integrated immunophenotyping of human PBMCs and mixed co-culture systems. [PDF]

Front Immunol
Kiel K, Małuszek M, Piwocka K, Godlewski J, Bronisz A.   +4 more
europepmc   +1 more source

Mechano‐Chemical Coordination of Nanoparticle‐Based Artificial Antigen‐Presenting Cells Synergistically Tunes T Cell Activation and Expansion Phenotypes

Small, EarlyView.
Mechanically distinct nano artificial antigen‐presenting cells with independently controlled antibody density are used to reveal how physical and biochemical cues jointly regulate human T‐cell activation. Increasing stiffness and antibody density accelerates activation, enhances expansion, and promotes effector‐associated differentiation, whereas ...
Zichao Guo, Fei Hou, Yali Zhang, Zilin Ye, Yang Li, Supun Ranaweera, Yue Hui, Chun‐Xia Zhao   +7 more
wiley   +1 more source

An optimized three-laser 27-color spectral flow cytometry panel for multi-organ profiling in mice. [PDF]

PLoS One
Song H, Lim Y, Lim J.
europepmc   +1 more source

Pyrene‐linked heterocyclic pyrazoles: Synthesis, antimicrobial screening, and in silico molecular insights

Smart Molecules, EarlyView.
A series of novel pyrene‐linked heterocyclic pyrazoles were synthesized and structurally characterized. The compounds were evaluated for antimicrobial activity against selected bacterial and fungal strains, showing promising inhibitory effects. Molecular docking studies provided insights into binding interactions and structure–activity relationships ...
Dinkal V. Kasundra, Paresh N. Patel
wiley   +1 more source