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[Development of fluoropyrimidine derivatives].
Gan to kagaku ryoho. Cancer & chemotherapy, 19845-Fluorouracil (5-FU), first synthesized by Heidelberger et al. in 1957 has been used extensively in the treatment of cancer. In the process of development antitumor drugs in fluoropyrimidine, 5-FU and 5-fluorodeoxyuridine (FdUrd) were chosen because these two drugs relatively were incorporated into tumor tissues more than into normal tissues.
S, Fujii, T, Shirasaka
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[Pharmacogenetics in fluoropyrimidine chemotherapy].
Gan to kagaku ryoho. Cancer & chemotherapy, 2008Pharmacogenetics has been widely studied to predict the clinical outcome including response, survival, and toxicity in patients treated by fluoropyrimidines based on a candidate approach. Several "candidate" gene expressions or polymorphisms in 5-fluorouracil pathway have been selected and identified retrospectively to correlate closely with the ...
Wataru, Ichikawa, Yasutsuna, Sasaki
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Oral fluoropyrimidines in the treatment of colorectal cancer
European Journal of Cancer, 19985-Fluorouracil (5-FU) has been the mainstay of systemic therapy for colorectal cancer since its initial development 40 years ago. Efforts to improve the therapeutic index of 5-FU have included alteration of schedule and addition of biochemical modulators.
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Pharmacological Modulation of Fluoropyrimidines
2005Few drugs in the present pharmacopia of antineoplastic pharmacology have exemplified the importance of the bench-to-bed paradigm that has become the cornerstone of present-day developmental chemotherapy. From its rational synthesis by Heidelberger in 1957 (1) to quantification of the molecular determinants of fluorinated pyrimidine (fluoropyrimidine ...
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