Results 71 to 80 of about 5,903 (227)
, 2021 There is an unmet medical need for later-line treatment options for patients with metastatic colorectal cancer (mCRC). Considering that, beyond progression, co-treatment with bevacizumab and cytotoxic chemotherapy showed less toxicity and a significant ...
이지성 +6 more
core +1 more source
Hepatology Research, EarlyView.ABSTRACT Aim To evaluate the frequency, imaging characteristics, associated factors, and clinical significance of biliary abnormalities on imaging in patients receiving lenvatinib (LEN) plus cisplatin hepatic arterial infusion chemotherapy (HAIC) for hepatocellular carcinoma (HCC).
Hirohito Osanai +10 more
wiley +1 more source
Long interspersed nuclear element-1 hypomethylation is a potential biomarker for the prediction of response to oral fluoropyrimidines in microsatellite stable and CpG island methylator phenotype-negative colorectal cancer [PDF]
, 2011 We investigated the clinical value of methylation of long interspersed nuclear element-1 (LINE-1) for the prognosis of colorectal cancer (CRC) and for the survival benefit from adjuvant chemotherapy with oral fluoropyrimidines.
47614 +14 more
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Internal Medicine Journal, EarlyView.Abstract Background Pharmacogenomic‐guided medication management optimises drug therapy to enhance patient outcomes. Despite clinical utility, implementation in Australia remains limited, partly due to the lack of clear and consistent guidance. Aim This study evaluated the presence and consistency of pharmacogenomic testing indication categories and ...
Ruby Soueid +4 more
wiley +1 more source
Déficits en dihydropyrimidine déshydrogénase et toxicité aux fluoropyrimidines
, 2013 La fréquence de prescription des fluoropyrimidines pour le traitement d'un nombre important de tumeurs solides depuis 1957, l'utilisation de frotes doses, l'extension des indications et la sévérité des toxicités aiguës dues à des déficits enzymatiques en
PAGES, Nicole, TUCCAR, Aline
core
Role of Radiation Therapy and Fluoropyrimidines in the Treatment of Gastrointestinal Malignancies
, 1996 Background The use of combined chemotherapy and radiation for gastrointestinal malignancies has several theoretical advantages, and clinical trials to determine the type and extent of clinical benefits have been performed.
Steven E. Schild +2 more
core +1 more source
, 2021 International audienceWe report the case of a 44-year-old patient who experienced severe toxicity while being treated with capecitabine at standard dose for metastatic breast cancer.
Marsili, Sabrina +7 more
core +1 more source
Translating Genomic Competencies Into Cancer Nursing Practice: A Scoping Review
Journal of Clinical Nursing, EarlyView.ABSTRACT Genomics‐informed cancer care is central to precision oncology; however, integrating genomic competencies into routine practice remains challenging. Despite the development of competency frameworks, limited clarity exists regarding how these competencies are operationalised within oncology settings. Aim To synthesise and critically examine how
Libby Rea Brownlee +5 more
wiley +1 more source
Novel fluoropyrimidines: Improving the efficacy and tolerability of cytotoxic therapy
, 2004 The fluoropyrimidines were first synthesised nearly 50 years ago as 4 rationally designed anti-cancer agents. Their target was pyrimidine and hence DNA synthesis. 5-Fluorouracil has been the most extensively used in a wide variety of malignancies.
Petty, RD +3 more
core +1 more source
Results of the use of ramucirumab in combination with irinotecan and fluoropyrimidines in the second-line chemotherapy for disseminated gastric cancer [PDF]
, 2019 Background: Several studies show that the combination chemotherapy with ramucirumab allows to improve the treatment results of advanced gastric cancer (GC).
E. S. Obarevich +8 more
core +1 more source