Results 51 to 60 of about 14,712 (219)
Drugs in R&DIntroduction In November 2018, the European Medicines Agency (EMA) restricted the use of fluoroquinolones (used by mouth, injections or inhalation) in the context of a referral due to long-lasting and potentially irreversible adverse drug reactions (ADRs)
Diana Dubrall +7 more
doaj +1 more source
Frontiers in Microbiology, 2019 Antimicrobial agents are crucial for the treatment of many bacterial diseases in pigs, however, the massive use of critically important antibiotics such as colistin, fluoroquinolones and 3rd–4th-generation cephalosporins often selects for co-resistance ...
Isidro García-Meniño +6 more
doaj +1 more source
Trend of multidrug and fluoroquinolone resistance in Mycobacterium tuberculosis isolates from 2010 to 2014 in Korea: a multicenter study [PDF]
The Korean Journal of Internal Medicine, 2019 Background/Aims This study was conducted to evaluate the recent prevalence and trend of anti-tuberculosis (TB) drug resistance with a focus on multidrug-resistance (MDR) and fluoroquinolone resistance in South Korea.
Hyeonseok Kim +7 more
doaj +1 more source
Designing a single-molecule biophysics tool for characterizing DNA damage for techniques that kill infectious pathogens through DNA damage effects [PDF]
arXiv, 2016 Antibiotics such as the quinolones and fluoroquinolones kill bacterial pathogens ultimately through DNA damage. They target the essential type IIA topoisomerases in bacteria by stabilising the normally transient double strand break state which is created to modify the supercoiling state of the DNA.
arxiv
CleanMat, EarlyView.Iron‐based catalysts activate peroxymonosulfate (PMS) to generate high‐valent iron‐oxo species for water decontamination and clean water production. The activation efficiency of PMS varies significantly depending on iron catalyst properties, while the generation of reactive high‐valent iron intermediates is governed by catalyst characteristics ...
Junpeng Guo +8 more
wiley +1 more source
Antimicrobial resistance and use, and rates of hospitalization associated with bacterial infections, including sepsis [PDF]
arXiv, 2018 While the mechanisms and quantitative details are complex, few analysts would doubt that antibiotic use increases the prevalence of drug-resistant bacterial pathogens among all bacteria causing disease in a population. The causal connection between antibiotic use and the total incidence of severe bacterial infections, possibly mediated by antibiotic ...
arxiv
ChemMedChem, Accepted Article.To search for new antitubercular agents, we have designed, synthesized, and evaluated a series of 1,4‐benzoxazinone‐based compounds. These molecules showed potent antimycobacterial activity, with MIC between 2 and 8 μg/mL. This interesting profile included activity against several drug‐resistant strains and minimal cytotoxicity against mammalian Vero ...
Daniele Zampieri +6 more
wiley +1 more source
Антибиотики и Химиотерапия, 2020 The efficacy of levofloxacin and moxyfloxacin vs. the previously tested fluoroquinolones was studied on albino mice with experimental plague due to the Nalr mutants of Yersinia pestis 231 and 231 FI-.
I. V. Ryzhko +2 more
doaj
Clinical Pharmacology in Drug Development, EarlyView.Abstract Sitafloxacin is a new antibiotic drug belonging to the fourth generation quinolone antibiotics. The aim of this study was to evaluate the pharmacokinetics (PK), safety profiles, and bioequivalence of test and reference 50‐mg sitafloxacin tablets under fasting and fed conditions.
Yongfang Lei +13 more
wiley +1 more source
Prevalence of Ciprofloxacin Resistance Among Gram-Negative Bacilli in a Tertiary Care Hospital [PDF]
Journal of Clinical and Diagnostic Research, 2012 Background: Bacterial resistance to antibiotics is a growing therapeutic problem, both in the community and the hospitals, which involves all the antibiotics including fluoroquinolones.
Mathavi Sureshkumar +3 more
doaj