Results 101 to 110 of about 174,614 (242)

Patient‐derived tumor organoids highlight the potential of precision medicine in managing pancreatic ductal adenocarcinoma

International Journal of Cancer, EarlyView.
What's New? Only about one‐fifth of patients with pancreatic ductal adenocarcinoma (PDAC) qualify for curative treatment approaches employing adjuvant chemotherapy. Tools to predict PDAC response to chemotherapeutic regimens, however, are lacking.
Christine Nitschke, Charline Phan, Yara Souto, Philipp Walter, Mara Goetz, Gediminas Simkus, Jacob Thastrup, Ronald Simon, Jürgen Kupper, Jakob Izbicki, Steven A. Johnsen, Thilo Hackert, Marianne Sinn, Harriet Wikman, Faik G. Uzunoglu, Tabea M. Sturmheit   +15 more
wiley   +1 more source

The association between additional radiotherapy after systemic chemotherapy and the prognosis of stage FIGO 2018 IVB cervical cancer

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Systemic platinum‐based chemotherapy is the first‐line treatment of choice for metastatic cervical cancer. While subsequent radiotherapy after primary chemotherapy is a potential option, its benefit remains unclear. This multicenter retrospective study aimed to evaluate whether post‐chemotherapy radiotherapy improves the prognosis of
Ai Miyoshi, Fumiaki Isohashi, Makoto Fujii, Tadashi Iwamiya, Masahiko Takemura, Yoshikazu Nagase, Takeshi Yokoi, Emi Yoshioka, Kimihiko Ito, Eri Yamabe, Kanji Masuhara, Tomoko Tsujie, Tadashi Kimura, Michiko Kodama   +13 more
wiley   +1 more source

Patient‐derived xenograft models in pan‐cancer: From bench to clinic

Interdisciplinary Medicine, EarlyView.
Abstract Patient‐derived xenograft (PDX) models provide a robust preclinical platform that preserves the genetic and phenotypic heterogeneity of patient tumors while mirroring their tumor genetic characteristics, which retain malignant cells and the tumor pathological structure, making them valuable for studying tumor progression and developing ...
Jiatong Li, Ao Gu, Nannan Tang, Gokhan Zengin, Meng‐Yao Li, Yingbin Liu   +5 more
wiley   +1 more source

From waste to reuse: Fenton degradation of anticancer drugs in hospital wastewater using iron mining residue

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND The heterogeneous photo‐Fenton process demands stable and efficient materials as catalysts to decompose hydrogen peroxide and generate reactive oxygen species to promote the degradation of organic contaminants in wastewater. In this study, the catalytic activity of an iron mining residue (IMR) was investigated for the heterogeneous ...
Nayara de M Costa‐Serge, Elissandro S Emídio, Karla VL Lima, Adriano L Tonetti, Raquel F Pupo Nogueira   +4 more
wiley   +1 more source

Circulating Tumor DNA as a Marker of Recurrence Risk in Stage III Colorectal Cancer: The α‐CORRECT Study

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Identification of colorectal cancer (CRC) patients at high risk of recurrence could be of substantial clinical use. We evaluated the association of ctDNA status, using a tumor‐informed assay, with recurrence‐free survival (RFS). Methods Stage III CRC patients were enrolled between 2016 and 2020.
Brenda Diergaarde, Greg Young, David W. Hall, Amin Mazloom, Gina L. Costa, Soma Subramaniam, Melanie R. Palomares, Jorge Garces, Frederick L. Baehner, Robert E. Schoen, Exact Sciences MRD Group, Gargi Basu, Jennifer Bungo, Darl Flake, John Hu, Scott Hunicke‐Smith, Andrea Johnson, Janine LoBello, Steve Lockton, Tara Marti, Suzanne Melanson, Bingbing Song, Matthew Wallace, Michal Wojcik, Martin You, Jenny You   +25 more
wiley   +1 more source

Phase I/II Trial of Perioperative Avelumab in Combination With Chemoradiation in the Treatment of Stage II/III Resectable Esophageal and Gastroesophageal Junction Cancer

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Standard treatment of patients with stage II/III esophageal or gastroesophageal junction (E/GEJ) cancer involves neoadjuvant chemoradiation (nCRT), resection, and immunotherapy. Our trial evaluated the addition of perioperative avelumab to standard treatments.
Nataliya V. Uboha, Mustafa M. Basree, Jens C. Eickhoff, Dustin A. Deming, Kristina Matkowskyj, James Maloney, Daniel McCarthy, Malcolm DeCamp, Noelle LoConte, Philip B. Emmerich, Sean Kraus, Monica A. Patel, Jeremy D. Kratz, Sam J. Lubner, Newton Hurst, Michael F. Bassetti   +15 more
wiley   +1 more source

Genomic Profiling of Biliary Tract Cancers: Comprehensive Assessment of Anatomic and Geographic Heterogeneity, Co‐Alterations and Outcomes

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background Biliary tract cancers (BTCs) represent distinct biological and genomic entities. Anatomic and geographic heterogeneity in genomic profiling of BTC subtypes, genomic co‐alterations, and their impact on long‐term outcomes are not well defined.
Diamantis I. Tsilimigras, Hunter Stecko, Dimitrios Moris, Timothy M. Pawlik   +3 more
wiley   +1 more source

Smoking and Elevated Preneoadjuvant Chemoradiotherapy Serum Carcinoembryonic Antigen Levels Are Associated With High Tumor Regression Grade and Poor Survival in Patients With Locally Advanced Rectal Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Neoadjuvant chemoradiotherapy (NACRT) is the standard treatment for patients with locally advanced rectal cancer (LARC). Tumor regression grade (TRG) is an essential prognostic factor in determining treatment efficacy. However, the potential factors influencing TRG in patients with rectal cancer who have received NACRT have not been ...
Jen‐Pin Chuang, Hsiang‐Lin Tsai, Po‐Jung Chen, Ching‐Wen Huang, Wei‐Chih Su, Tsung‐Kun Chang, Yen‐Cheng Chen, Ching‐Chun Li, Yung‐Sung Yeh, Jaw‐Yuan Wang   +9 more
wiley   +1 more source

Chemotherapy May Influence Esophageal Lugol Chromoendoscopy Severity: A Retrospective Cohort Study and Literature Review

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Lugol chromoendoscopy is widely used for screening esophageal squamous cell neoplasms (ESCNs) and evaluating dissection margins during endoscopic submucosal dissection (ESD). However, morphological variations may arise following treatment for synchronous cancers.
Wen‐Hung Hsu, Chien‐Chieh Lin, Hsiang‐Yao Shih, Leong‐Perng Chan, Hui‐Ching Wang, Yi‐Hsun Chen, Yu‐Chung Hsu, Hui‐Min Hsieh, I‐Chen Wu   +8 more
wiley   +1 more source

Efficacy of Combined 5-Fluorouracil and Photodynamic Therapy in Glioma Spheroids

, 2018
Standard treatment regimens consisting of surgery, radiation and chemotherapy have proven ineffective for the treatment of high-grade gliomas such as glioblastoma multiforme (GBM).
Singh, Karanjit
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