Results 121 to 130 of about 142,003 (296)

Inclusion Complexations of Levamisole and Cocaine With Molecular Baskets. Fluorescence Displacement Assay for Detection of Cocaine and Its Adulterant Levamisole in Aqueous Media

Chemistry – A European Journal, EarlyView.
Levamisole is a common adulterant found in street‐distributed cocaine. Molecular baskets have been shown to form stable inclusion complexes with both substances. While levamisole inserts its benzene into the basket's cavity, cocaine utilizes its bicyclic ring for encapsulation.
Christopher T. Mortensen, Carson E. Ward, Nitesh Kumar, Logan Willemann, Ryan Lutz, Kailey Hughes, Zheng Zheng, Jovica D. Badjić   +7 more
wiley   +1 more source

A phase II study of continuous-infusion 5-fluorouracil with cisplatin and epirubicin in inoperable pancreatic cancer [PDF]

, 1996
Evans, TR, Lofts, FJ, TRJ Evans, Dalgleish, AG, JL Mansi, Knight, MJ, Mansi, JL, AG Dalgleish, Glees, JP, FJ Lofts, JP Glees, MJ Knight   +11 more
core   +1 more source

Microbiome and Tumor Microenvironment Interactions: Advances From Ecological Niches to Precision Oncology

Cancer Nexus, EarlyView.
Tumor‐associated microbiota occupies spatially organized ecological niches and influence cancer progression by reshaping tumor‐cell signaling, metabolism, immunity, stromal remodeling, and therapeutic response. Integrating microbiome‐derived biomarkers, targeted microbial interventions, spatial multi‐omics, longitudinal monitoring, and AI may enable ...
Yiwen Zhang, Ji'an Liu, Jing Li, Xue Liu, Yang Su, Peng Luo, Yuhan Zhang, Zhengrui Li   +7 more
wiley   +1 more source

Patients with colorectal tumors with microsatellite instability and large deletions in HSP110 T17 have improved response to 5-fluorouracil-based chemotherapy

, 2014
Background & Aims: Patients with colorectal tumors with microsatellite instability (MSI) have better prognoses than patients with tumors without MSI, but have a poor response to 5-fluorouracil–based chemotherapy.
P. Delarue (23366188), K. Wanherdrick (23366155), C. Lepage (23366176), C. Garrido (23366218), A. Lagrange (23366140), R. Soong (23359123), C. Tournigand (23366203), A. Bouvier (17993692), C. Chapusot (23366173), J. Fléjou (23366215), M. Svrcek (23366143), A. Guilloux (23366152), Y. Parc (23366209), D. Biard (23366212), H. Arzouk (23366191), P. Senet (23366185), C. Dorard (21367175), J. Lefèvre (23366206), A. De Thonel (23366164), A. Collura (7582016), A. Taieb (23366158), A. Coquelle (23366197), A. Mews (23322748), B. Iacopetta (23309023), G. Milano (2177086), C. Platell (23317438), J. Selves (23366182), G. Marcion (23366170), C. Lacoste (23366194), A. Duval (23366221), L. Marisa (23366146), L. Bengrine-Lefèvre (23366200), R. Seigneuric (23366167), O. Buhard (23366149), M. Loh (7737329), M. Gaub (23366179), Nikolajs Zeps (23309692), A. Saget (23366161)   +37 more
core  

5-Fluorouracil

, 2019
Inelastic Neutron Scattering spectrum of 5-Fluorouracil, C4H3FN2O2, measured on the TOSCA instrument.
Tan, J-C.
core   +1 more source

Long‐Term Prognosis, Residual Recurrence Risk, and Postoperative Management After Pathological Complete Response in Rectal Cancer

Cancer Nexus, EarlyView.
This graphical abstract summarizes the post‐pCR clinical pathway in locally advanced rectal cancer. After neoadjuvant radiotherapy and systemic therapy followed by surgery, patients achieving pCR (ypT0N0) generally have durable disease control, although residual risks of local and distant recurrence remain. Risk assessment, guideline‐based surveillance,
Jia‐ang Wang, Yingjiang Ye, Zhidong Gao, Sen Hou   +3 more
wiley   +1 more source

5-fluorouracil metabolism.

, 2016
5-fluorouracil metabolism.
Bruna Cerbelli (3133278), Marina Borro (440234), Claudia Sebastiani (3133269), Maurizio Simmaco (440241), Federica Mazzuca (3133257), Luca Marchetti (3133275), Andrea Botticelli (3133263), Giovanna Gentile (3133266), Paolo Marchetti (393307), Adriana Romiti (3133281), Luana Lionetto (3133254), Concetta Elisa Onesti (3133272), Mario Occhipinti (3133260), Lidia Strigari (51527)   +13 more
core   +1 more source

Unraveling the Multimodal Oncogenic Network of KITENIN: From Metabolic Reprogramming and Microenvironment Remodeling to Targeted Interventions

Cancer Nexus, EarlyView.
ABSTRACT KAI1 C‐terminal interacting tetraspanin (KITENIN) is an emerging oncogenic regulator associated with tumorigenesis, metastasis, therapeutic resistance, and poor clinical outcomes. Mechanistically, KITENIN promotes tumor cell proliferation, migration, invasion, and epithelial–mesenchymal transition (EMT) by activating oncogenic pathways ...
Niaz Mahmood Tanoy, Zarin Tasnim, Md Shiblee Sadik Sabuj, Tanvir Ahmed, Md Abdul Momin, Md Sadekuzzaman, Sumaia Islam Mow, Md Aktaruzzaman, Md Rashedunnabi Akanda   +8 more
wiley   +1 more source

Maternal and Neonatal Complications Associated with Breast Cancer Systemic Treatments—A VigiBase Disproportionality Analysis Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnancy‐associated breast cancer (PrBC) presents therapeutic challenges. Understanding maternal–fetal safety of systemic anticancer therapies is critical. We performed a case/non‐case disproportionality analysis using the WHO global pharmacovigilance database up to January 2024, to evaluate maternal–fetal outcomes associated with breast cancer (BC ...
Rayan Kabirian, Floriane Jochum, Elise Dumas, Florence Coussy, Kevin Bihan, Bénédicte Lebrun‐Vignes, Barbara Pistilli, Marc‐Antoine Benderra, Lise Selleret, Laurent Chouchana, Fabien Reyal, Anne‐Sophie Hamy, Paul Gougis   +12 more
wiley   +1 more source

Dispensing of actionable pharmacogenetic drugs among adults receiving cardiovascular disease medications in the Northern Netherlands: A serial cross‐sectional study

Clinical Pharmacology &Therapeutics, EarlyView.
The extent of pharmacogenetic (PGx) drug dispensing among Dutch adults receiving medications for cardiovascular disease (CVD) is unknown. Using the University of Groningen IADB.nl pharmacy database, we performed a serial cross‐sectional study (2019–2023) to estimate the annual prevalence of PGx drug dispensing and annual rates of initiation.
Zhuolin Zhang, Guiling Zhou, Jens H. J. Bos, Eelko Hak, Talitha Feenstra, Frank Klont   +5 more
wiley   +1 more source