Results 131 to 140 of about 290,304 (371)

Mature Tertiary Lymphoid Structures Indicate Good Chemotherapy Response and Prognosis in Advanced Colorectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
In advanced colorectal cancer, tumors with mature tertiary lymphoid structures (TLS) exhibited abundant infiltration of CD3‐ and CD8‐positive lymphocytes in both primary and metastatic sites, indicating an activated immune response. The presence of mature TLS was also associated with favorable chemotherapy sensitivity and improved prognosis.
Nobuhiro Hosoi, Chika Komine, Gendensuren Dorjkhorloo, Takuya Shiraishi, Takuhisa Okada, Akihiko Sano, Makoto Sakai, Takehiko Yokobori, Ken Shirabe, Hiroshi Saeki   +9 more
wiley   +1 more source

Mechanisms of base selection by the E.coli mispaired uracil glycosylase [PDF]

, 2008
The repair of the multitude of single-base lesions formed daily in the cells of all living organisms is accomplished primarily by the base-excision repair (BER) pathway that initiates repair through a series of lesion-selective glycosylases.
Darwanto, Agus, Goddard, William, III, Liu, Pingfang, Pascal, Tod, Sowers, Lawrence C., Theruvathu, Jacob A., Valinluck Lao, Victoria   +6 more
core   +2 more sources

Impact of Body Weight Loss During Preoperative Chemoradiotherapy on Prognosis of Patients With Lower Rectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
The present study aimed to investigate the relationship between changes in body weight and composition during chemoradiotherapy, such as the psoas muscle mass index, visceral fat index, and subcutaneous fat index obtained from computed tomography images, and long‐term outcomes in rectal cancer patients.
Shinya Abe, Hiroaki Nozawa, Kazuhito Sasaki, Koji Murono, Shigenobu Emoto, Yuichiro Yokoyama, Yuzo Nagai, Yuzo Harada, Takahide Shinagawa, Soichiro Ishihara   +9 more
wiley   +1 more source

Efficacy and Safety of Hepatic Artery Infusion Chemotherapy Combined with Donafenib and Camrelizumab in the Treatment of Patients with Unresectable Hepatocellular Carcinoma: A Retrospective, Single-Arm Study

Journal of Hepatocellular Carcinoma
Chenrui Wu,1,* Zixuan Fu,1,* Long Pan,1 Jiachu Li,2 Yin Zhou,3 Ruirui Sun,1 Yang Gou,1 Yaowu Zhao,1 Zhouyan Wang,1 Yuhao Qiu,1 Ping Huang1 1Department of Hepatobiliary Surgery, First Affiliated Hospital of Chongqing Medical University ...
Wu C, Fu Z, Pan L, Li J, Zhou Y, Sun R, Gou Y, Zhao Y, Wang Z, Qiu Y, Huang P   +10 more
doaj  

Enhancement by Terpenes of 5-Fluorouracil Permeation through the Stratum Comeum: Model Solvent Approach [PDF]

, 1998
Hamid Reza Moghimi, Adrian C. Williams, Brian Barry   +2 more
openalex   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

Low-dose continuous infusion 5-fluorouracil. Evaluation in advanced breast carcinoma [PDF]

, 1989
S. Huan, Richard Pazdur, Amnuay Singhakowinta, Bohumil A. Samal, Vainutis K. Vaitkevicus   +4 more
openalex   +1 more source

Bioinformatics‐based discovery of the involvement of PSAT1 in mediating the anti‐lung adenocarcinoma activity of triptolide

Animal Models and Experimental Medicine, EarlyView.
Transcriptome sequencing was performed on tumor tissues from triptolide‐treated tumor‐bearing mice. The sequencing results were integrated with data from public databases for comprehensive analysis, and potential regulatory targets of triptolide were identified.
Zhiwen Cao, Lulu Zhang, Wenqiang Zhang, Rong Wan, Xiaogang Peng, Jinyan Xie, Ruru Bai, Jiejing Jin, Changqi Shi, Lan Yan, Xiangyu Guo, Yang Shen, Cheng Lu   +12 more
wiley   +1 more source

Implantable Drug Delivery Systems for Skeletal Muscles and Eyes

Advanced NanoBiomed Research, EarlyView.
This review highlights the different types of recent implantable drug delivery systems (IDDS) fabricated for a use with skeletal muscles, and with eyes. It presents the developments already made and the current research directions, showing the evolution of IDDS and their great diversity.
Serge Ostrovidov, Murugan Ramalingam, Hongkai Wu, Toshinori Fujie, Yukinari Nakamura, Takeshi Hori, Yuji Nashimoto, Xuetao Shi, Hirokazu Kaji   +8 more
wiley   +1 more source

UTILITY OF DERIVATIVE SPECTROPHOTOMETRY FOR THE DETERMINATION OF FLUOROURACIL IN COMBINATION WITH ITS ALKALI - INDUCED DEGRADATION PRODUCTS [PDF]

, 1994
Hesham Salem, Magda El-Maamli, Mohamed El‐Sadek, Afaf Aboul Kheir   +3 more
openalex   +1 more source