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Corticosteroids and Fluorouracil Toxicity [PDF]
Archives of Internal Medicine, 1966 FLUOROURACIL has found a definite place in the treatment of advanced cancer, especially those tumors primary in the breast or colon. 1 Probably the most disturbing toxic manifestation of this drug is the development of severe and occasionally lethal granulocytopenia.
Kenneth B. Olson +2 more
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Phenytoin and Fluorouracil Interaction
Annals of Pharmacotherapy, 2001OBJECTIVE: To report a probable drug interaction between phenytoin and fluorouracil. CASE REPORT: A 66-year-old white man started adjuvant chemotherapy for colon cancer with weekly bolus injections of fluorouracil and leucovorin calcium. He had been taking phenytoin 300 mg/d for epilepsy for more than four years.
Gilbar, PJ, Brodribb, TR
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Fluorouracil-Induced Neurotoxicity
Annals of Pharmacotherapy, 2000OBJECTIVE: To report a case of acute neurologic adverse effects related to fluorouracil administration and to review the neurotoxicity of this agent. CASE SUMMARY: A 73-year-old white man with a history of esophageal carcinoma was treated with fluorouracil 1500 mg iv daily for four days.
Imran I. Ali +2 more
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Cardiotoxicity of 5-Fluorouracil
Tumori Journal, 1980A case is reported of cardiotoxicity during a multiple drug treatment with fluorouracil, vincristine and CCNU in a patient with a large bowel cancer without any precedent history of heart disease. The patient had chest pain, with an altered ECG and increased serum levels of αHBDH.
Germano Zampa, Teresa Gamucci
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Trabeculectomy with 5‐fluorouracil
Acta Ophthalmologica, 1991Abstract The effect of subconjunctival injection of 5‐fluorouracil (5‐FU) after trabeculectomy was studied retrospectively in 205 eyes of 168 patients. A life table analysis of the surgical outcome was based on the type of glaucoma and age related differences, and a comparison was made with patients who had trabeculectomy without subconjunctival 5‐FU ...
Kazuo Iwata +3 more
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GLC Determination of Fluorouracil
Journal of Pharmaceutical Sciences, 1974A GLC assay method for fluorouracil, based on the flash-methylation technique using trimethylanilinium hydroxide, was developed. It is a convenient, rapid, and sensitive method for the determination in urine and other biological fluids. An ion-exchange recovery method was also developed, using a combination of strong acid and weak base resins and ...
Koppaka V. Rao +2 more
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Archives of Dermatology, 1969
A patient with actinic keratoses was treated with three different fluorouracil preparations topically without the development of reaction. Purposeful exposure to hot sunlight failed to cause any inflammation even though he was applying the fluorouracil at this time.
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A patient with actinic keratoses was treated with three different fluorouracil preparations topically without the development of reaction. Purposeful exposure to hot sunlight failed to cause any inflammation even though he was applying the fluorouracil at this time.
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Lacrimation and 5-Fluorouracil
Annals of Internal Medicine, 1978Excerpt To the editor: Recently Haidak, Hurwitz, and Yeung (1) reported in your journal that excessive lacrimation occurred in six patients receiving weekly injections of 5-fluorouracil during a pe...
N. Christophidis +3 more
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Gynecologic Oncology, 1990
Two cases of 5-fluorouracil-induced neurotoxicity from the University of North Carolina are presented. 5-Fluorouracil metabolism is briefly discussed with reference to possible mechanisms for the neurotoxicity. A possible role for thiamine supplementation in the prevention of this unusual complication is supported by our experience.
David H. Moore +2 more
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Two cases of 5-fluorouracil-induced neurotoxicity from the University of North Carolina are presented. 5-Fluorouracil metabolism is briefly discussed with reference to possible mechanisms for the neurotoxicity. A possible role for thiamine supplementation in the prevention of this unusual complication is supported by our experience.
David H. Moore +2 more
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