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Impact of Physical Frailty on Early Intolerance to CAPOX Chemotherapy in Patients With Colon, Rectal, and Gastric Cancer

open access: yesCancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Patients with gastrointestinal cancer often present reduction in functional capacity and develop frailty, which increases the risk of chemotherapy intolerance. We investigated whether physical frailty is associated with early intolerance to CAPOX (capecitabine+oxaliplatin) in patients with colon, rectal, or gastric cancer.
Isabella Pellegrini Grama Pereira Lima   +9 more
wiley   +1 more source

Phase II randomised study of magrolimab combined with bevacizumab-FOLFIRI in patients with previously treated advanced inoperable metastatic colorectal cancer. [PDF]

open access: yesESMO Gastrointest Oncol
Fakih M   +19 more
europepmc   +1 more source
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Fluorouracil Cardiotoxicity

Annals of Pharmacotherapy, 1994
OBJECTIVE: To review the clinical manifestations, postulated mechanisms, and therapeutic implications of fluorouracil-induced cardiac toxicity. DATA SOURCE: A MEDLINE search was used to identify pertinent literature. STUDY SELECTION: Studies and case reports on fluorouracil cardiotoxicity were identified through a MEDLINE search.
openaire   +2 more sources

Resistance to Fluorouracil

Archives of Dermatology, 1969
A patient with actinic keratoses was treated with three different fluorouracil preparations topically without the development of reaction. Purposeful exposure to hot sunlight failed to cause any inflammation even though he was applying the fluorouracil at this time.
openaire   +2 more sources

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