Small, EarlyView.The study introduces a 3D sensing‐integrated platform enabling real‐time, non‐invasive monitoring of pH dynamics in patient‐derived PDAC tumorspheres. It revealed distinct extracellular acidification patterns under FOLFIRINOX, gemcitabine, and paclitaxel, correlating with therapeutic efficacy.
Stefania Forciniti +10 more
wiley +1 more source
4% 5-Fluorouracil Cream for Actinic Keratoses: First Report of Efficacy and Tolerability in a Person Living With Human Immunodeficiency Virus Infection. [PDF]
Clin Case RepHoxhallari G +10 more
europepmc +1 more source
Rare Cutaneous Metastasis From Esophageal Squamous Cell Carcinoma
The Kaohsiung Journal of Medical Sciences, EarlyView.
Sarah Hsin Cheng +3 more
wiley +1 more source
Smart Molecules, EarlyView.The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou +4 more
wiley +1 more source
Wernicke Encephalopathy During Neoadjuvant Folinic Acid, Fluorouracil, and Oxaliplatin (FOLFOX) Therapy for Rectal Adenocarcinoma: A Case Report and Review of Diagnostic Challenges. [PDF]
CureusBaron M, Abuhayyeh H, Shariff B.
europepmc +1 more source
Advances in research on layered double hydroxides for biomedical applications
Smart Molecules, EarlyView.Layered double hydroxides (LDHs) are pH‐responsive nanomaterials with broad biomedical applications. This review summarizes LDH synthesis methods and compares their advantages. It highlights LDHs' progress in cancer therapy, including chemo‐photothermal, chemo‐immunotherapy, and photodynamic‐immunotherapy combinations and their potential in bone repair.
Xinhui Yang +13 more
wiley +1 more source
Concurrent Intestinal Tuberculosis and Colon Cancer in a Young Patient: A Diagnostic Challenge. [PDF]
ACG Case Rep JA A, Kini R, Karunakaran PK.
europepmc +1 more source
Recent Advances in Oriented Hydrogels: From Fundamental Mechanisms to Future Challenges
SusMat, EarlyView.Traditional hydrogels suffer from weak mechanical properties and limited functionality due to their random polymer networks. This review comprehensively summarizes the reinforcement mechanisms of oriented structure for hydrogels, the design/fabrication strategies, and the latest application progress of high‐strength oriented hydrogels.
Chang Xu, Xijing Zhuang
wiley +1 more source
Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity
VIEW, EarlyView.Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin +3 more
wiley +1 more source
Targeting mitochondrial dysfunction and apoptosis in 5-fluorouracil-induced cardiotoxicity using kaempferol-mediated selenium nanoparticles. [PDF]
Sci RepNasr SM +9 more
europepmc +1 more source