Results 161 to 170 of about 105,478 (251)

The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao, Yuheng Qin, Haoyu Wan, Guang Lu, Han‐Ming Shen   +4 more
wiley   +1 more source

Correction: Mitomycin, 5-fluorouracil, and radiotherapy for anal canal cancer in a patient undergoing hemodialysis: a case report. [PDF]

Int Cancer Conf J
Ozawa Y.
europepmc   +1 more source

Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong, Jieni Li, Mingxuan Pan, Xiaoxue Ke, Hongjuan Cui   +4 more
wiley   +1 more source

Current Systemic Treatment Options for Advanced Pancreatic Cancer-An Overview Article. [PDF]

Biomedicines
Domagała-Haduch M, Długaszek A, Gorzelak-Magiera A, Gisterek-Grocholska I.   +3 more
europepmc   +1 more source

Metformin as a Multifaceted Therapeutic Agent for Gastrointestinal Diseases: Mechanisms, Clinical Efficacy, and Future Directions

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT The high prevalence of gastrointestinal (GI) diseases and their significant impact on the quality of life require new therapeutic strategies. The development of novel therapeutic strategies should prioritize targeting the fundamental pathophysiological mechanisms underlying these diseases, including inflammation, cellular proliferation, and ...
Sayedeh Azimeh Hosseini, Hassan Valadbeigi, Seyedeh Mahdieh Khoshnazar, Saeed Khoshnood, Shahab Falahi, Delsuz Rezaee, Ali Hematian, Mohammad Hossein Haddadi   +7 more
wiley   +1 more source

Unveiling the potential of apigenin and kaempferol against colon cancer: an integrated network pharmacology and docking approach. [PDF]

Front Bioinform
Selvakumar A, Chandran PA, Shraddha S, Dharshini LCP, Perumal S, Karuppasamy R, Mandal AKA.   +6 more
europepmc   +1 more source

Fibril Synthesis From Food Processing By‐Products and Strategies for Structure–Function Stabilization for Food Applications

Sustainable Food Proteins, Volume 4, Issue 2, June 2026.
Protein fibrils can be synthesized from both conventional and by‐product protein sources, each having distinct advantages. Stabilization through polysaccharides and polyphenols can enhance fibril functional properties, such as gelling, foaming, and emulsification, thus furthering their application in food and non‐food materials.
Sanjana Sawant, Audrey L. Girard
wiley   +1 more source

Molecular Mechanism of Caspase-8-Dependent Interleukin-18 Activation in Pancreatic Cancer Cells Induced by 5-Fluorouracil and Nutrient Starvation. [PDF]

Genes Cells
Kamino H, Nariai Y, Urano T.
europepmc   +1 more source

Effects of Chemotherapeutic Agents (5‐Fluorouracil, Cisplatin and Methotrexate) on Cell Adhesion Molecules and Oxidative Damage Markers in Rat Kidney Tissue

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 6, June 2026.
Chemotherapy with 5‐fluorouracil, cisplatin or methotrexate induces significant renal oxidative stress, DNA damage and dysregulation of apoptosis‐ and cell adhesion‐related proteins in rats. Cisplatin causes the most severe oxidative injury, whereas methotrexate predominantly alters apoptotic and cell adhesion pathways.
Serdar Emre Ozyapici, Melek Ozturkler Dundar, Onur Atakisi   +2 more
wiley   +1 more source

Impact of prior chemotherapy on nanoliposomal irinotecan with fluorouracil and folinic acid for unresectable pancreatic cancer: a retrospective analysis of data from the multicenter NAPOLEON-2 study. [PDF]

Ther Adv Med Oncol
Koike T, Kawaguchi Y, Shimokawa M, Otsuka T, Furukawa K, Shinohara Y, Shimokawa H, Yoshihiro T, Shibuki T, Nakazawa J, Arima S, Miwa K, Koga F, Ueda Y, Kubotsu Y, Takeshita S, Nishikawa K, Komori A, Otsu S, Hosokawa A, Sakai T, Oda H, Kawahira M, Arita S, Honda T, Taguchi H, Tsuneyoshi K, Fujita T, Sakae T, Shirakawa T, Mizuta T, Mitsugi K.   +31 more
europepmc   +1 more source