Results 181 to 190 of about 107,610 (251)

Raltitrexed in Hepatocellular Carcinoma: Mechanistic Rationale and Clinical Evidence from Arterial-Based Therapies. [PDF]

J Hepatocell Carcinoma
Jia X, Ding Y, Chen Y, Wang W.
europepmc   +1 more source

The selective degradation of PDE4B shortform, using a PROTAC, leads to inhibition of several hallmarks of cancer in HCT116 cells

British Journal of Pharmacology, Volume 183, Issue 18, Page 5516-5540, September 2026.
Background and Purpose Colorectal cancer is one of the most prevalent cancers worldwide, and novel precision medicine approaches are rapidly improving patient outcomes. Phosphodiesterase 4B (PDE4B) is a member of an enzyme family (PDE4) that hydrolyses intracellular cAMP to control spatial and temporal signalling cues.
Alina Zorn, John Daniel Pediani, Madihah Hussain, Jiayue Ling, Elaine Brown, Igor Belka, Eduardo Torres, Cathy Swindlehurst, Kyle Chan, David Stirling, George S. Baillie, Yuan Yan Sin   +11 more
wiley   +1 more source

Optimal surgical timing following neoadjuvant chemoradiotherapy in patients with rectal cancer: a systematic review and network meta-analysis. [PDF]

Am J Transl Res
Tao Z, Jiang Y, Gui Q, Ma J.
europepmc   +1 more source

Identification of Novel Therapeutic Agent Candidates Through High Throughput Screening With Chemical Library Based on Molecular Subclassification in Canine Histiocytic Sarcoma Cell Lines

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 554-567, September 2026.
ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma, Hirotaka Tomiyasu, Mari Takamiya, Yuko Goto‐Koshino, Atsushi Tsukamoto, Makoto Bonkobara, Masaru Okuda   +6 more
wiley   +1 more source

Cell Line-Dependent Cell Death Pathways Induced by Thymoquinone in Colorectal Cancer Cells. [PDF]

Molecules
Kurowska N, Książek M, Borkowska P, Strzałka-Mrozik B.   +3 more
europepmc   +1 more source

Disease‐free survival as a surrogate outcome for localized kidney cancer—A systematic review and meta‐analysis

Cancer, Volume 132, Issue 16, 15 August 2026.
Abstract Background Disease‐free survival (DFS) is commonly used as a primary end point in trials for localized renal cell carcinoma (RCC), although its validity as a surrogate for overall survival (OS) remains uncertain. The objective of this study was to evaluate whether DFS is a reliable surrogate end point for OS in this setting.
Constanza Martinez, David Chen, Russell Leong, Nicholas Lum, Karren Xiao, Laith Almasri, Christian K. Kollmannsberger, Srinivas Raman   +7 more
wiley   +1 more source

Anti-EGFR-based maintenance versus stop and go in patients with left-sided, non-MSI-H, RAS/BRAF-wt metastatic colorectal cancer: individual patient data pooled analysis. [PDF]

ESMO Open
Raimondi A, Tinè G, Boige V, De Stefano A, Ballhausen A, Gourgou S, Giuliani F, Stahler A, Randon G, Prisciandaro M, Manca P, Ambrosini M, Fazio R, Mohamed S, Gronchi G, Santabarbara G, Brument E, Alig AHS, Miceli R, Bouche O, Modest DP, Avallone A, Pietrantonio F.   +22 more
europepmc   +1 more source

The effect of neo-adjuvant chemotherapy with 5-fluorouracil on the integrity of colonic anastomoses: a systematic review and meta-analysis of experimental studies on rats. [PDF]

Front Surg
Chernyshenko T, Polkin R, Ashyrov M, Shepelev V, Goncharuk R.   +4 more
europepmc   +1 more source

Induction Cisplatin, Docetaxel, and 5-Fluorouracil Versus Platinum Doublet in Human Papillomavirus-Associated Oropharyngeal Cancer. [PDF]

Viruses
Ganti A, McGarrah PW, Fuentes Bayne H, Fazer-Posorske C, Baral B, Ma DJ, Lester SC, Routman DM, Neben-Wittich MA, Wilson JM, Price DL, Moore EJ, Tasche KK, Van Abel KM, Yin LX, Foster NR, Price K.   +16 more
europepmc   +1 more source