Results 81 to 90 of about 290,304 (371)

Comparing Paclitaxel Plus Fluorouracil Versus Cisplatin Plus Fluorouracil in Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Cancer: A Randomized, Multicenter, Phase III Clinical Trial

Journal of Clinical Oncology, 2019
PURPOSE This trial aimed to assess the efficacy and safety of the paclitaxel plus fluorouracil regimen versus the cisplatin plus fluorouracil regimen in definitive concurrent chemoradiotherapy (dCRT) in patients with locally advanced esophageal squamous ...
Yun Chen, Jinjun Ye, Zhengfei Zhu, Weixin Zhao, Jialiang Zhou, Chaoyang Wu, Hua-Rong Tang, M. Fan, Ling Li, Q. Lin, Yi Xia, Yun-hai Li, Jiancheng Li, Huixun Jia, Saiquan Lu, Zhen Zhang, K. Zhao   +16 more
semanticscholar   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Visual acuity after trabeculectomy [PDF]

Vojnosanitetski Pregled, 2005
Background/Aim. In this study we compared the two groups of glaucoma patients who had underwent trabeculectomy, with or without intraoperative application of antimetabolite 5-Fluorouracile (5 FU). Methods. We followed up 50 glaucoma patients (group I) in
Buzarovska-Blaževska Karolina, Jordanova-Dimovska Vesna, Vukosavljević Miroslav, Džajkovska Elena   +3 more
doaj   +1 more source

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, EarlyView.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source

Modification of gemcitabine with oxaliplatin in China for unresectable gallbladder cancer: a cost-effectiveness analysis

Frontiers in Public Health
BackgroundThe incidence of gall bladder cancer (GBC), one of the most prevalent bile duct malignancies, differs with ethnicity and geographic location. To treat unresected GBC in the Chinese setting, this study aimed to assess the financial effectiveness
Zhaoyan Chen, Fangyuan Tian
doaj   +1 more source

Comparison of the suppressing capecitabine and 5-fluorouracil effects on the pronounce of inflammatory cells score in the induction of episcleral fibrosis after trabeculectomy [PDF]

Vojnosanitetski Pregled, 2007
Background/Aim. Trabeculectomy is a filtering antiglaucoma surgery performed to facilitate the formation of a drainage channel for the aqueous humor from the anterior chamber of the eye to the subconjunctival space making a collector, filtering cushion ...
Milivojević Milorad, Vukosavljević Miroslav, Aleksić Petar, Stojković Radovan, Dimitrijević Jovan, Latković Zoran, Avramović Siniša   +6 more
doaj   +1 more source

Homoisoflavanone Delays Colorectal Cancer Progression via DNA Damage‐Induced Mitochondrial Apoptosis and Parthanatos‐Like Cell Death

Advanced Science, EarlyView.
Homoisoflavanone (HIF), a bioactive compound isolated from Polygonatum kingianum, selectively suppresses colorectal cancer progression by inducing DNA damage‐mediated mitochondrial apoptosis and parthanatos‐like cell death. HIF triggers mitochondrial dysfunction, including depolarized membrane potential, elevated ROS, and ATP depletion, while impairing
Hongjie Fan, Huzi Zhao, Pei Zhang, Pengfei Yu, Yunfei Ji, Gang Chen, Hongli Jin, Yanfang Liu, Jin Liu, Zhe‐Sheng Chen, Aiping Lyu, Xinmiao Liang, Yang Chen   +12 more
wiley   +1 more source

Influence of the skeletal muscle index on pharmacokinetics and toxicity of fluorouracil

Cancer Medicine, 2023
Background The body composition of patients has been associated with tolerability and effectiveness of anticancer therapy. This study aimed to assess the influence of the skeletal muscle index (SMI) on the pharmacokinetics and toxicity of fluorouracil ...
Eduard Schmulenson, Nigina Zimmermann, Lothar Müller, Stefanie Kapsa, Iryna Sihinevich, Ulrich Jaehde   +5 more
doaj   +1 more source

Feasibility and morbidity of combined hyperthermia and radiochemotherapy in recurrent rectal cancer - Preliminary results [PDF]

, 2003
Background: The local recurrence rate of colorectal cancer has been significantly reduced due to the use of combined radiochemotherapy. Despite this improvement regarding locally advanced tumour recurrences, the treatment strategy for pre-treated ...
Abdel-Rahman, Sultan, Dühmke, Eckhart, Ertl-Wagner, Birgit, Issels, Rolf-Dieter, Krych, M., Pachmann, S., Schaffer, Moshe, Schaffer, Pamela Manuela   +7 more
core   +1 more source

A 2D Porous Zinc-Organic Framework Platform for Loading of 5-Fluorouracil [PDF]

, 2022
Liang Qin, Fenglan Liang, Yan Li, Jiana Wu, Shiyuan Guan, Wu Meiyin, Shiling Xie, Manshi Luo, De‐Yun Ma   +8 more
openalex   +1 more source