Results 1 to 10 of about 87,517 (311)

Fluoxetine Potentiates Phagocytosis and Autophagy in Microglia

Frontiers in Pharmacology, 2021
Fluoxetine is a classic antidepressant drug, and its immunomodulatory effects have recently been reported in many disease models. In addition, it has strong antineuroinflammatory effects in stroke and neurodegenerative animal models.
Sung Hee Park, Young-Sun Lee, Young-Sun Lee, Hyun-Jeong Yang, Gyun Jee Song, Gyun Jee Song   +5 more
doaj   +1 more source

Assessing the Mechanism of Fluoxetine-Mediated CYP2D6 Inhibition

Pharmaceutics, 2021
Fluoxetine is still one of the most widely used antidepressants in the world. The drug is extensively metabolized by several cytochrome P450 (CYP450) enzymes and subjected to a myriad of CYP450-mediated drug interactions.
Malavika Deodhar, Sweilem B. Al Rihani, Lucy Darakjian, Jacques Turgeon, Veronique Michaud   +4 more
doaj   +1 more source

Analysis of Adherence to Fluoxetine Treatment through its Plasma Concentration

Brazilian Journal of Pharmaceutical Sciences, 2023
Depression plays an important role in non-adherence to medical recommendations. Fluoxetine is a first line of depression treatment. This study aimed to evaluate adherence to drug therapy in fluoxetine users by different methods. A cross-section study was
Juliana Raquel Raasch, Tainara Gomes Vargas, Andressa Schmidt dos Santos, Roberta Ziles Hahn, Anne Caroline Cezimbra da Silva, Marina Venzon Antunes, Rafael Linden, Andresa Heemann Betti, Magda Susana Perassolo   +8 more
doaj   +1 more source

Fluoxetine exerts age-dependent effects on behavior and amygdala neuroplasticity in the rat. [PDF]

PLoS ONE, 2011
The selective serotonin reuptake inhibitor (SSRI) Prozac® (fluoxetine) is the only registered antidepressant to treat depression in children and adolescents.
Judith R Homberg, Jocelien D A Olivier, Tom Blom, Tim Arentsen, Chantal van Brunschot, Pieter Schipper, Gerdien Korte-Bouws, Gilles van Luijtelaar, Liesbeth Reneman   +8 more
doaj   +1 more source

Antidepressants Fluoxetine Mediates Endoplasmic Reticulum Stress and Autophagy of Non–Small Cell Lung Cancer Cells Through the ATF4-AKT-mTOR Signaling Pathway

Frontiers in Pharmacology, 2022
Fluoxetine, one of the latest clinical antidepressants, is reported to have the anti-proliferative effect on cancer cells via immune-related pathways. However, the mechanism is still not known.
Shali Shao, Xibing Zhuang, Lin Zhang, Tiankui Qiao   +3 more
doaj   +1 more source

Fluoxetine improves bone microarchitecture and mechanical properties in rodents undergoing chronic mild stress – an animal model of depression

Translational Psychiatry, 2022
Depression is one of the most prevalent mental disorders associated with reductions in bone mineral density and increased fracture risk. Fluoxetine is a highly prescribed selective serotonin reuptake inhibitor (SSRI) in the treatment of depression and is
Raymond W. Lam, Hee-Kit Wong, Ramruttun A. Kumarsing, Anna N. Chua, Roger C. Ho, Roger S. McIntyre, Cyrus S. Ho   +6 more
doaj   +1 more source

Factors associated with fluoxetine and norfluoxetine plasma concentrations and clinical response in Mexican patients with mental disorders

Pharmacology Research & Perspectives, 2021
Over the last few years, fluoxetine has been one of the most prescribed medications for the treatment of diverse psychiatric conditions in Mexico.
Julia Sagahón‐Azúa, Susanna Edith Medellín‐Garibay, Cinthya Eloisa Chávez‐Castillo, César Guillermo González‐Salinas, Rosa del Carmen Milán‐Segovia, Silvia Romano‐Moreno   +5 more
doaj   +1 more source

Pharmacogenetics of fluoxetine

Personalized Psychiatry and Neurology, 2021
There is a number of antidepressants (ADs) which prevent reabsorption of neurotransmitters in the body. Known together as reuptake inhibitors, they prevent the reuptake of one or some neurotransmitters so that the majority of them is present and active in the brain.
S. D. Skopin, V. V. Kravtsov, M. A. Novitsky   +2 more
openaire   +3 more sources

Emergence of Fluoxetine-Resistant Variants during Treatment of Human Pancreatic Cell Cultures Persistently Infected with Coxsackievirus B4

Viruses, 2019
This study reports the antiviral activity of the drug fluoxetine against some enteroviruses (EV). We had previously established a model of persistent coxsackievirus B4 (CVB4) infection in pancreatic cell cultures and demonstrated that fluoxetine could ...
Enagnon Kazali Alidjinou, Antoine Bertin, Famara Sane, Delphine Caloone, Ilka Engelmann, Didier Hober   +5 more
doaj   +1 more source

Corticosterone facilitates fluoxetine-induced neuronal plasticity in the hippocampus. [PDF]

PLoS ONE, 2013
The hippocampal dentate gyrus has been implicated in a neuronal basis of antidepressant action. We have recently shown a distinct form of neuronal plasticity induced by the serotonergic antidepressant fluoxetine, that is, a reversal of maturation of the ...
Katsunori Kobayashi, Yumiko Ikeda, Minoru Asada, Hirofumi Inagaki, Tomoyuki Kawada, Hidenori Suzuki   +5 more
doaj   +1 more source