Fluoxetine: a case history of its discovery and preclinical development [PDF]
, 2014 Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N +20 more
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Fluoxetine Prevents the Development of Depressive-like Behavior in a Mouse Model of Cancer Related Fatigue [PDF]
, 2015 Cancer patients frequently suffer from fatigue, a complex syndrome associated with tiredness and depressed mood. Cancer-related fatigue (CRF) can be present at the time of diagnosis, escalates during treatment, and can persist for years after treatment ...
Bicer, Sabahattin +7 more
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Risk of suicide during treatment with venlafaxine, italopram, fluoxetine, and dothiepin : retrospective cohort study [PDF]
, 2006 Objective To compare the risk of suicide in adults usingthe antidepressant venlafaxine compared with citalopram, fluoxetine, and dothiepin. Design Retrospective cohort study. Setting UK General Practice Research Database. Participants 219 088 patients,
Andrews, Elizabeth +5 more
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Uptake, accumulation and metabolization of the antidepressant fluoxetine by Mytilus galloprovincialis [PDF]
, 2016 Fluoxetine, a selective serotonin re-uptake inhibitor (SSRI) antidepressant, is among the most prescribed pharmaceutical active substances worldwide. This study aimed to assess its accumulation and metabolization in the mussel Mytillus galloprovincialis,
André M.P.T. Pereira +39 more
core +1 more source
Frontiers in Behavioral Neuroscience, 2021 Impaired behavioral activation and effort-related motivational dysfunctions like fatigue and anergia are debilitating treatment-resistant symptoms of depression. Depressed people show a bias towards the selection of low effort activities. To determine if
Carla Carratalá-Ros +5 more
doaj +1 more source
Impact of fluoxetine on testosterone levels and spermatogenic cell production of male albino mice [PDF]
Caspian Journal of Environmental Sciences, 2023 Fluoxetine is a widely used antidepressant that acts as a selective serotonin reuptake inhibitor. This study investigated the effects of fluoxetine hydrochloride on the hypothalamic-pituitary-testicular axis and spermatogenesis in male albino mice. Fifty
Mardan N. Julanov +8 more
doaj +1 more source
Serotonin and motherhood: From molecules to mood [PDF]
, 2019 Emerging research points to a valuable role of the monoamine neurotransmitter, serotonin, in the display of maternal behaviors and reproduction-associated plasticity in the maternal brain.
Li, Ming +2 more
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Using a new high-throughput video-tracking platform to assess behavioural changes in Daphnia magna exposed to neuro-active drugs [PDF]
, 2019 © 2019. ElsevierOne of the major challenges that faces today regulatory risk assessment is to speed up the way of assessing threshold sublethal detrimental effects of existing and new chemical products.
Barata Martí, Carlos +8 more
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Oxytocin exerts harmful cardiac repolarization prolonging effects in drug-induced LQTS
International Journal of Cardiology: Heart & Vasculature, 2022 Background: Oxytocin is used therapeutically in psychiatric patients. Many of these also receive anti-depressant or anti-psychotic drugs causing acquired long-QT-syndrome (LQTS) by blocking HERG/IKr.
Paul Kreifels +12 more
doaj +1 more source
Selective serotonin reuptake inhibitors (SSRIs) for stroke recovery. [PDF]
, 2011 BACKGROUND: Stroke is the major cause of adult disability. Selective serotonin reuptake inhibitors (SSRIs) have been used for many years to manage depression.
Anne Claxton +6 more
core +1 more source