Results 11 to 20 of about 105,140 (274)

Fluoxetine inhibited the activation of A1 reactive astrocyte in a mouse model of major depressive disorder through astrocytic 5-HT2BR/β-arrestin2 pathway

Journal of Neuroinflammation, 2022
Background Fluoxetine, a selective serotonin reuptake inhibitor, has been reported to directly bind with 5-HT2B receptor (5-HT2BR), but the precise mechanisms, whereby fluoxetine confers the anti-depressive actions via 5-HT2BR is not fully understood ...
Yinquan Fang, Xiao Ding, Yihe Zhang, Lei Cai, Yuan Ge, Kaiyang Ma, Rong Xu, Shanshan Li, Mengmeng Song, Hong Zhu, Jiaqi Liu, Jianhua Ding, Ming Lu, Gang Hu   +13 more
doaj   +2 more sources

Fluoxetine attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage: a possible role for the regulation of TLR4/MyD88/NF-κB signaling pathway

Journal of Neuroinflammation, 2018
Background Neuroinflammation is closely associated with functional outcome in subarachnoid hemorrhage (SAH) patients. Our recent study demonstrated that fluoxetine inhibited NLRP3 inflammasome activation and attenuated necrotic cell death in early brain ...
Fu-yi Liu, Jing Cai, Chun Wang, Wu Ruan, Guo-ping Guan, Hai-zhou Pan, Jian-ru Li, Cong Qian, Jing-sen Chen, Lin Wang, Gao Chen   +10 more
doaj   +2 more sources

Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression

Journal of Neuroinflammation, 2021
Background Selective serotonin reuptaker inhibitors, including fluoxetine, are widely studied and prescribed antidepressants, while their exact molecular and cellular mechanism are yet to be defined.
Wei-fen Li, T. Ali, Chengyou Zheng, Zizhen Liu, Kaiwu He, F. Shah, Qing-Guo Ren, S. Rahman, Ningning Li, Zhi-jian Yu, Shupeng Li   +10 more
semanticscholar   +1 more source

Identification of fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Dry age-related macular degeneration (AMD) affects the vision of millions of people worldwide. There is currently no Food and Drug Administration–approved treatment for dry AMD.
Meenakshi Ambati, Ivana Apicella, Shao-bin Wang, S. Narendran, Hannah Leung, Felipe Pereira, Yosuke Nagasaka, Peirong Huang, Akhil Varshney, Kirstie L. Baker, Kenneth M. Marion, Mehrdad Shadmehr, Cliff I. Stains, B. Werner, S. Sadda, E. Taylor, S. Sutton, J. Magagnoli, Bradley D. Gelfand   +18 more
semanticscholar   +1 more source

Safety and efficacy of fluoxetine on functional recovery after acute stroke (EFFECTS): a randomised, double-blind, placebo-controlled trial.

Lancet Neurology, 2020
BACKGROUND Studies have suggested that fluoxetine could improve neurological recovery after stroke. The Efficacy oF Fluoxetine-a randomisEd Controlled Trial in Stroke (EFFECTS) trial aimed to assess whether administration of oral fluoxetine for 6 months ...
E. Lundström, Eva Isaksson, P. Näsman, P. Wester, B. Mårtensson, B. Norrving, H. Wallén, J. Borg, M. Dennis, G. Mead, G. Hankey, M. Hackett, K. Sunnerhagen   +12 more
semanticscholar   +1 more source

The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2

bioRxiv, 2020
To circumvent time-consuming clinical trials, testing whether existing drugs are effective inhibitors of SARS-CoV-2, has led to the discovery of Remdesivir.
M. Zimniak, Luisa Kirschner, Helen Hilpert, J. Seibel, J. Bodem   +4 more
semanticscholar   +1 more source

Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut

Nature Microbiology, 2019
The gut microbiota regulates levels of serotonin (5-hydroxytryptamine (5-HT)) in the intestinal epithelium and lumen1–5. However, whether 5-HT plays a functional role in bacteria from the gut microbiota remains unknown.
Thomas C. Fung, H. Vuong, Cristopher D. G. Luna, Geoffrey N Pronovost, Antoniya A. Aleksandrova, N. G. Riley, Anastasia Vavilina, Julianne McGinn, Tomiko K. Rendon, L. Forrest, E. Hsiao   +10 more
semanticscholar   +1 more source

Impact of fluoxetine on testosterone levels and spermatogenic cell production of male albino mice [PDF]

Caspian Journal of Environmental Sciences, 2023
Fluoxetine is a widely used antidepressant that acts as a selective serotonin reuptake inhibitor. This study investigated the effects of fluoxetine hydrochloride on the hypothalamic-pituitary-testicular axis and spermatogenesis in male albino mice. Fifty
Mardan N. Julanov, Meruyert E. Alimbekova, Symbat S. Usmangaliyeva, Gulnar E. Turganbayeva, Kanat U. Koibagarov, Orynbay O. Tagayev, Baitlessov U. Yerbulat, Saule N. Sarimbekova, Akhan J. Myrzaliev   +8 more
doaj   +1 more source

Fluoxetine Prevents the Development of Depressive-like Behavior in a Mouse Model of Cancer Related Fatigue [PDF]

, 2015
Cancer patients frequently suffer from fatigue, a complex syndrome associated with tiredness and depressed mood. Cancer-related fatigue (CRF) can be present at the time of diagnosis, escalates during treatment, and can persist for years after treatment ...
Bicer, Sabahattin, Devine, Raymond, Godbout, Jonathan P., Jing, Runfeng, McCarthy, Donna O., Norden, Diana M., Reiser, Peter J., Wold, Loren E.   +7 more
core   +2 more sources

Serotonin and motherhood: From molecules to mood [PDF]

, 2019
Emerging research points to a valuable role of the monoamine neurotransmitter, serotonin, in the display of maternal behaviors and reproduction-associated plasticity in the maternal brain.
Li, Ming, Lonstein, Joseph S., Pawluski, Jodi L.   +2 more
core   +3 more sources