Using a new high-throughput video-tracking platform to assess behavioural changes in Daphnia magna exposed to neuro-active drugs [PDF]
, 2019 © 2019. ElsevierOne of the major challenges that faces today regulatory risk assessment is to speed up the way of assessing threshold sublethal detrimental effects of existing and new chemical products.
Barata Martí, Carlos +8 more
core +1 more source
Study on anti-inflammatory and immunomodulatory effects of fluoxetine in rat models of inflammation
European Journal of Inflammation, 2015 The aim of the present study was to evaluate the anti-inflammatory effect of fluoxetine in carrageenan- and lipoplysaccharide-induced models of inflammation by investigating the changes in serum levels of pro-inflammatory cytokine TNF-α and anti ...
Ilia Kostadinov +7 more
doaj +1 more source
Veterinary Integrative Sciences, 2022 Fluoxetine is an antidepressant that acts as a selective serotonin reuptake inhibitor. Fluoxetine has exhibited different mechanisms of action on many different cell lines.
Thi Tho Nguyen, Thi Mong Diep Nguyen
doaj +1 more source
A meta-analysis of pharmacotherapy for social anxiety disorder: an examination of efficacy, moderators, and mediators [PDF]
, 2017 INTRODUCTION: Social anxiety disorder (SAD) is among the most prevalent mental disorders, associated with impaired functioning and poor quality of life. Pharmacotherapy is the most widely utilized treatment option.
Borenstein M +8 more
core +2 more sources
The Possible Role of Fluoxetine in Adenomyosis: An Animal Experiment with Clinical Correlations [PDF]
Journal of Clinical and Diagnostic Research, 2013 Introduction: Fluoxetine is a commonly prescribed drug which is used in the psychiatric practice and adenomyosis is a common medical problem in women of the reproductive age group.
Parama Sengupta +6 more
doaj +1 more source
Critical appraisal and update on the clinical utility of agomelatine, a melatonergic agonist, for the treatment of major depressive disease in adults [PDF]
, 2009 This article describes the pharmacology of the novel atypical antidepressant drug agomelatine, critically reviews and evaluates its clinical use for the treatment of major depression, and suggests areas for further research.
Howland, RH
core +1 more source
(Poly)Borylated Species as Modern Reactive Groups toward Unusual Synthetic Applications
Angewandte Chemie, EarlyView.In this review, we spotlight recent breakthroughs in α‐polyboron‐substituted carbon‐centered intermediates (carbanion, carbocation, radical, and carbene) and polyborylated alkenes. By bridging fundamental reactivity with the application potential of these extraordinary species, we hope this review will serve as a roadmap for harnessing these unique ...
Nadim Eghbarieh +5 more
wiley +2 more sources
Fluoxetine-induced Hypotension: A Case Report
Pharmaceutical and Biomedical Research, 2023 Fluoxetine is a Selective Serotonin Reuptake Inhibitor (SSRI) that exerts its anti-depressive effect by blocking the presynaptic reuptake of the neurotransmitter serotonin, 5-hydroxytryptamine (5-HT).
Seyed Hamzeh Hosseini +2 more
doaj
Quantitative cross-species extrapolation between humans and fish: The case of the anti-depressant fluoxetine [PDF]
, 2014 This article has been made available through the Brunel Open Access Publishing Fund.Fish are an important model for the pharmacological and toxicological characterization of human pharmaceuticals in drug discovery, drug safety assessment and ...
ABA Boxall +80 more
core +3 more sources
A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model. [PDF]
, 2018 We describe here the results from the testing of a small molecule first-in-class apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer, A03, that increases the levels of the neuroprotective enzyme SirT1 while not affecting levels of neurotoxic ...
Bai, Dongsheng +14 more
core +3 more sources