Results 21 to 30 of about 105,140 (274)

Norfluoxetine Is the Only Metabolite of Fluoxetine in Zebrafish (Danio rerio) Embryos That Accumulates at Environmentally Relevant Exposure Scenarios.

Environmental Science and Technology, 2020
Fluoxetine has been recognized as one of the most toxic pharmaceuticals in the aquatic environment. Since there is growing evidence that the toxic potential of fluoxetine in surface waters is markedly influenced by its own metabolism in aquatic species ...
Florian Zindler, Selina Tisler, Ann-Kathrin Loerracher, C. Zwiener, T. Braunbeck   +4 more
semanticscholar   +1 more source

Impact of Fluoxetine on Behavioral Invigoration of Appetitive and Aversively Motivated Responses: Interaction With Dopamine Depletion

Frontiers in Behavioral Neuroscience, 2021
Impaired behavioral activation and effort-related motivational dysfunctions like fatigue and anergia are debilitating treatment-resistant symptoms of depression. Depressed people show a bias towards the selection of low effort activities. To determine if
Carla Carratalá-Ros, Laura López-Cruz, Andrea Martínez-Verdú, Régulo Olivares-García, John D. Salamone, Mercè Correa   +5 more
doaj   +1 more source

Selective serotonin reuptake inhibitors (SSRIs) for stroke recovery. [PDF]

, 2011
BACKGROUND: Stroke is the major cause of adult disability. Selective serotonin reuptake inhibitors (SSRIs) have been used for many years to manage depression.
Anne Claxton, Cheng-Fang Hsieh, Gillian E Mead, Graeme J Hankey, Mansur A Kutlubaev, Maree L Hackett, Rebecca Lee   +6 more
core   +1 more source

Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial

The Lancet, 2019
Summary Background Results of small trials indicate that fluoxetine might improve functional outcomes after stroke. The FOCUS trial aimed to provide a precise estimate of these effects.
Maree Hackett, M. Dennis, J. Forbes, C. Graham, G. Hankey, A. House, S. Lewis, E. Lundström, P. Sandercock, G. Mead, C. Watkins   +10 more
semanticscholar   +1 more source

Quantitative cross-species extrapolation between humans and fish: The case of the anti-depressant fluoxetine [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.Fish are an important model for the pharmacological and toxicological characterization of human pharmaceuticals in drug discovery, drug safety assessment and ...
ABA Boxall, AC Altamura, AC Johnson, Anna de Polo, BJ Ring, C Charlier, C Hiemke, C Lillesaar, C Maximino, CA LaLone, CB Eap, D Baldwin, D Kokel, DB Huggett, DJ Caldwell, DS Baldwin, ED Levin, EJ Perkins, FM McRobb, G Jannuzzi, GG Gould, Grace H. Panter, GT Ankley, J Cachat, J Klooster, J Kristensen, J Lundmark, J Rihel, J Rihel, JA Mennigen, JD Amsterdam, JG Kohlert, Jodi Pawluski, John P. Sumpter, JP Berninger, JP Seiler, JP Sumpter, JP Sumpter, JT Pittman, JV Goldstone, K Kuemmerer, KD Oakes, L Bjerkenstedt, L Fjordside, L Gunnarsson, L Ibrahim, L Margiotta-Casaluci, LD Ellis, Luigi Margiotta-Casaluci, M Rand-Weaver, M Schulz, M Sundvik, M Wolman, MA Lopez-Patino, Mariann Rand-Weaver, Matthew J. Winter, MC Celander, MG Scordo, MJ Airhart, MJ Owens, MJ Winter, MS Lipsky, MW Kelly, PD Anderson, RF Bergstrom, RJ Egan, Rob I. Cumming, RY Wong, SC Baraban, SC Dulawa, SH Preskorn, SH Preskorn, Stewart F. Owen, TJ Runnalls, TR Norman, TW Valenti Jr, TW Valenti Jr, WJAJ Smeets, YH Zhang, YJ Kim, Z Bencan   +80 more
core   +3 more sources

The effect of fluoxetine on astrocyte autophagy flux and injured mitochondria clearance in a mouse model of depression

Cell Death and Disease, 2019
Although multiple hypotheses had been proposed to clarify the causes of depression, the accurate pathogenesis and effective treatment of depression still need to be solved.
Xiao-dong Shu, Yiming Sun, Xiyang Sun, Yuanzhang Zhou, Y. Bian, Zhaoma Shu, Jian-hua Ding, Ming Lu, G. Hu   +8 more
semanticscholar   +1 more source

Oxytocin exerts harmful cardiac repolarization prolonging effects in drug-induced LQTS

International Journal of Cardiology: Heart & Vasculature, 2022
Background: Oxytocin is used therapeutically in psychiatric patients. Many of these also receive anti-depressant or anti-psychotic drugs causing acquired long-QT-syndrome (LQTS) by blocking HERG/IKr.
Paul Kreifels, Ilona Bodi, Tibor Hornyik, Gerlind Franke, Stefanie Perez-Feliz, R. Lewetag, Robin Moss, Alessandro Castiglione, David Ziupa, Manfred Zehender, Michael Brunner, Christoph Bode, Katja E. Odening   +12 more
doaj   +1 more source

Open Channel Block of Kv3.1 Currents by Fluoxetine

Journal of Pharmacological Sciences, 2008
The action of fluoxetine, a serotonin reuptake inhibitor, on the cloned neuronal rat Kv3.1 channels stably expressed in Chinese hamster ovary cells was investigated using the whole-cell patch-clamp technique.
Min Ji Sung, Hye Sook Ahn, Sang June Hahn, Bok Hee Choi   +3 more
doaj   +1 more source

Effect of fluoxetine on cyclic adenosine monophosphate response to follicle-stimulating hormone in HEK cells

Veterinary Integrative Sciences, 2022
Fluoxetine is an antidepressant that acts as a selective serotonin reuptake inhibitor. Fluoxetine has exhibited different mechanisms of action on many different cell lines.
Thi Tho Nguyen, Thi Mong Diep Nguyen
doaj   +1 more source

A meta-analysis of pharmacotherapy for social anxiety disorder: an examination of efficacy, moderators, and mediators [PDF]

, 2017
INTRODUCTION: Social anxiety disorder (SAD) is among the most prevalent mental disorders, associated with impaired functioning and poor quality of life. Pharmacotherapy is the most widely utilized treatment option.
Borenstein M, Hofmann SG, Jasper Smits, Joshua Curtiss, Leigh Andrews, Lipsey MW, Michelle Davis, Stefan G. Hofmann, Stein MB   +8 more
core   +2 more sources