Open Channel Block of Kv3.1 Currents by Fluoxetine
Journal of Pharmacological Sciences, 2008 The action of fluoxetine, a serotonin reuptake inhibitor, on the cloned neuronal rat Kv3.1 channels stably expressed in Chinese hamster ovary cells was investigated using the whole-cell patch-clamp technique.
Min Ji Sung +3 more
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Veterinary Integrative Sciences, 2022 Fluoxetine is an antidepressant that acts as a selective serotonin reuptake inhibitor. Fluoxetine has exhibited different mechanisms of action on many different cell lines.
Thi Tho Nguyen, Thi Mong Diep Nguyen
doaj +1 more source
Critical appraisal and update on the clinical utility of agomelatine, a melatonergic agonist, for the treatment of major depressive disease in adults [PDF]
, 2009 This article describes the pharmacology of the novel atypical antidepressant drug agomelatine, critically reviews and evaluates its clinical use for the treatment of major depression, and suggests areas for further research.
Howland, RH
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Study on anti-inflammatory and immunomodulatory effects of fluoxetine in rat models of inflammation
European Journal of Inflammation, 2015 The aim of the present study was to evaluate the anti-inflammatory effect of fluoxetine in carrageenan- and lipoplysaccharide-induced models of inflammation by investigating the changes in serum levels of pro-inflammatory cytokine TNF-α and anti ...
Ilia Kostadinov +7 more
doaj +1 more source
The Possible Role of Fluoxetine in Adenomyosis: An Animal Experiment with Clinical Correlations [PDF]
Journal of Clinical and Diagnostic Research, 2013 Introduction: Fluoxetine is a commonly prescribed drug which is used in the psychiatric practice and adenomyosis is a common medical problem in women of the reproductive age group.
Parama Sengupta +6 more
doaj +1 more source
A meta-analysis of pharmacotherapy for social anxiety disorder: an examination of efficacy, moderators, and mediators [PDF]
, 2017 INTRODUCTION: Social anxiety disorder (SAD) is among the most prevalent mental disorders, associated with impaired functioning and poor quality of life. Pharmacotherapy is the most widely utilized treatment option.
Borenstein M +8 more
core +2 more sources
A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model. [PDF]
, 2018 We describe here the results from the testing of a small molecule first-in-class apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer, A03, that increases the levels of the neuroprotective enzyme SirT1 while not affecting levels of neurotoxic ...
Bai, Dongsheng +14 more
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Fluoxetine-induced Hypotension: A Case Report
Pharmaceutical and Biomedical Research, 2023 Fluoxetine is a Selective Serotonin Reuptake Inhibitor (SSRI) that exerts its anti-depressive effect by blocking the presynaptic reuptake of the neurotransmitter serotonin, 5-hydroxytryptamine (5-HT).
Seyed Hamzeh Hosseini +2 more
doaj
Brazilian Journal of Oral Sciences, 2015 Aim: To evaluate the morphological aspects of coronal dentinogenesis in the first molars of 1- and 5-day-old rats whose mothers were treated with fluoxetine hydrochloride during pregnancy.
Isabela Maria de Albuquerque Santiago +5 more
doaj +1 more source
The Effect of ABCB1 Polymorphisms on the Efficacy of Antidepressants. [PDF]
Basic Clin Pharmacol ToxicolABSTRACT This scoping review investigates the association between ABCB1 polymorphisms and antidepressant efficacy in humans. A systematic search identified 630 records, of which 58 met the inclusion criteria, resulting in 42 unique studies (five randomised controlled trials (RCTs), two randomised studies (non‐RCTs), 30 prospective cohort studies, three
Thorsen SV +3 more
europepmc +2 more sources