Results 51 to 60 of about 696 (211)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Zooplankton and micronekton active flux around the Iberian Peninsula

Frontiers in Marine Science
The biological carbon pump comprises a set of processes that transfer organic carbon from the ocean surface to its depths, playing a vital role in the global carbon cycle.
María Couret, Airam N. Sarmiento-Lezcano, Airam N. Sarmiento-Lezcano, José María Landeira, Sarah L. C. Giering, Will Major, M. Pilar Olivar, Javier Díaz-Pérez, Arturo Castellón, Santiago Hernández-León   +9 more
doaj   +1 more source

Reduction of calcium flux from the extracellular region and endoplasmic reticulum by amorphous nano-silica particles owing to carboxy group addition on their surface

Biochemistry and Biophysics Reports, 2017
Several studies have reported that amorphous nano-silica particles (nano-SPs) modulate calcium flux, although the mechanism remains incompletely understood.
Akira Onodera, Katsutoshi Yayama, Hideto Morosawa, Yukina Ishii, Yasuo Tsutsumi, Yuichi Kawai   +5 more
doaj   +1 more source

Topological Magnetic Flux Pumping Revisited [PDF]

Symposium - International Astronomical Union, 1983
Calculations by Drobyshevski and Yuferev (1974) suggest that magnetic flux is ‘topologically pumped’ to the bottom of a convecting Benard layer as the electrical conductivity is increased. This is shown to be mistaken: however, compressible flows where motion is mainly around fieldlines can confine flux near their base.
openaire   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Bacteria as Passive Passengers in the Equatorial Pacific Biological Carbon Pump

Geophysical Research Letters
Bacteria are important agents modulating the efficiency of the ocean's biological carbon pump (BCP). The long‐standing view considers bacteria as degraders of sinking particulate organic carbon (POC), yet underappreciates their contribution to carbon ...
Jinqiang Guo, Huamao Yuan, Yao Gao, Eric P. Achterberg, Frédéric A. C. Le Moigne, Rainer Kiko, Yuan Shen   +6 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The role of divertor pumping combined with full drifts in particle exhaust and divertor plasma

Nuclear Fusion
The effect of drifts combined with pumping on particle exhaust is assessed using the SOLPS-ITER code package, considering full drifts. Both drift and pumping speed S can affect particle exhaust.
Xuele Zhao, Chaofeng Sang, Yilin Wang, Chen Zhang, Dezhen Wang   +4 more
doaj   +1 more source