Results 61 to 70 of about 34,615 (301)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

GaN-based fast, high output magnetic field pulser

AIP Advances, 2021
Magnetic field pulsers (MFP) generate a pulsed magnetic field by driving current through an inductor. These pulsers have numerous applications based on the output magnetic flux density and switching time.
W. S. Theh, N. Prabhu Gaunkar, M. Mina
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Fixed Switching Frequency Direct Model Predictive Control of Synchronous Reluctance Machines Based on Stator Flux Gradients

IEEE Access
This paper proposes a direct model predictive control method with a fixed switching frequency for stator flux control of a synchronous reluctance machine.
Ivana Zagorscak, Luka Pravica, Igor Erceg, Sandor Iles   +3 more
doaj   +1 more source

Investigation of a Co-Axial Dual-Mechanical Ports Flux-Switching Permanent Magnet Machine for Hybrid Electric Vehicles

Energies, 2015
In this paper, a co-axial dual-mechanical ports flux-switching permanent magnet (CADMP-FSPM) machine for hybrid electric vehicles (HEVs) is proposed and investigated, which is comprised of two conventional co-axial FSPM machines, namely one high-speed ...
Wei Hua, Ling Kang Zhou
doaj   +1 more source

A novel axial air‐gap transverse flux switching PM generator: Design, simulation and prototyping

IET Electric Power Applications, 2023
Wind energy as the cleanest source of renewable energy requires a highly efficient lightweight generator that provides maximum power density while having the least vibration noise and maintenance.
Aghil Ghaheri, Ebrahim Afjei, Hossein Torkaman   +2 more
doaj   +1 more source

Nonlinear Performance Characteristics of Flux-Switching PM Motors [PDF]

Journal of Engineering, 2013
Nonlinear performance characteristics of 3-phase flux-switching permanent magnet motors (FSPM) are overviewed. These machines show advantages of a robust rotor structure and a high energy density. Research on the FSPM is predominated by topics such as modeling and machine comparison, with little emphasis given on its performance and limits. Performance
E. Ilhan, M. F. J. Kremers, T. E. Motoasca, J. J. H. Paulides, E. A. Lomonova   +4 more
openaire   +3 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cogging Torque Mitigation using the Unequal Rotor Slot Arcs Method based on Magnetic Permeance Distribution for Flux-Switching Machines [PDF]

Journal of Electromagnetic Engineering and Science
Permanent magnet machines, such as flux-switching permanent magnet (FSPM) machines, are characterized by cogging torque, which must be addressed because it leads to torque fluctuations.
Emrah Cetin
doaj   +1 more source