Results 101 to 110 of about 713,945 (299)

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Gauge Fluxes in F-theory and Type IIB Orientifolds

, 2012
We provide a detailed correspondence between G_4 gauge fluxes in F-theory compactifications with SU(n) and SU(n)x(1) gauge symmetry and their Type IIB orientifold limit.
A Collinucci, A Collinucci, A Collinucci, A Collinucci, A Sen, AP Braun, B Andreas, B Andreas, BR Greene, C Beasley, C Beasley, C Vafa, C-M Chen, Christoph Mayrhofer, D Gaiotto, D Lüst, DR Morrison, DR Morrison, DR Morrison, DS Freed, DS Park, E Plauschinn, E Witten, F Bonetti, G Curio, H Hayashi, H Hayashi, H Jockers, J Knapp, J Marsano, J Marsano, J Marsano, M Alim, M Bershadsky, M Bianchi, M Cvetič, M Cvetič, P Mayr, R Blumenhagen, R Blumenhagen, R Blumenhagen, R Blumenhagen, R Blumenhagen, R Blumenhagen, R Friedman, R Tatar, RY Donagi, S Katz, S Krause, SH Katz, Sven Krause, T Weigand, Timo Weigand, TW Grimm, TW Grimm, TW Grimm, TW Grimm, TW Grimm, TW Grimm, TW Grimm, V Kumar   +60 more
core   +1 more source

Dynamical Horizons: Energy, Angular Momentum, Fluxes and Balance Laws [PDF]

, 2002
Dynamical horizons are considered in full, non-linear general relativity. Expressions of fluxes of energy and angular momentum carried by gravitational waves across these horizons are obtained.
Abhay Ashtekar, Badri Krishnan, R. M. Wald   +2 more
core   +2 more sources

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Global mapping of flux and microbial sources for oceanic N2O

Nature Communications
The ocean is the largest source of N2O emissions from global aquatic ecosystems. However, the N2O production–consumption mechanism and microbial spatial distribution are still unclear.
Shuo Wang, Jilin Huang, Zhen Wu, Shengjie Li, Xianfang Zhu, Yong Liu, Guodong Ji   +6 more
doaj   +1 more source

Assessment of the Plastic Inputs From the Seine Basin to the Sea Using Statistical and Field Approaches

Frontiers in Marine Science, 2019
Global estimations state that between 0.5 and 12.7 million metric tons of plastic enter the oceans each year. They are, however, associated with great uncertainties due to methodological difficulties to accurately quantify land-based plastic fluxes into ...
Romain Tramoy, Johnny Gasperi, Rachid Dris, Rachid Dris, Laurent Colasse, Cédric Fisson, Sarah Sananes, Vincent Rocher, Bruno Tassin   +8 more
doaj   +1 more source

Gravitational Instantons and Fluxes from M/F-theory on Calabi-Yau fourfolds

, 2011
We compactify four-dimensional N=1 gauged supergravity theories on a circle including fluxes for shift-symmetric scalars. Four-dimensional Taub-NUT gravitational instantons universally correct the three-dimensional superpotential in the absence of fluxes.
A. P. Braun, D. S. Freed, H. Jockers, P. McGuirk, Raffaele Savelli, S. A. Cherkis, Thomas W. Grimm   +6 more
core   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Wind Sheltering Impacts on Land-Atmosphere Fluxes Over Fens

Frontiers in Environmental Science, 2019
Wetlands and their ability to mitigate climate change motivates restorative and protective action; however, scientific understanding of land-atmosphere interactions is restricted by our limited continuous observations of gaseous fluxes. Many wetlands are
Jessica Turner, Ankur R. Desai, Jonathan Thom, Kimberly P. Wickland, Brent Olson   +4 more
doaj   +1 more source