Results 41 to 50 of about 259,276 (311)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Decoding the Wickedness of Resource Nexus Problems—Examples from Water-Soil Nexus Problems in China

Resources, 2018
Managing environmental resources in a nexus manner is typically denoted as a highly wicked problem. Such denotations are, however, barely based on clearly defined dimensions and degrees of wickedness.
Sabrina Kirschke, Lulu Zhang, Kristin Meyer   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Particle Fluxes in the North-East Atlantic and Southern Ocean [PDF]

, 2007
Concerns regarding the climatic implications of the increase in atmospheric CO2 concentrationsthroughout the anthropocene have provided the impetus to obtain a mechanistic understandingof oceanic processes and their role in regulating atmospheric pCO2 ...
Salter, Ian
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Particle fluxes and gross erosion at limiters in JET low-confinement mode plasmas measured with visible cameras

Nuclear Fusion
Deuterium (D) and beryllium (Be) fluxes are obtained in JET Low-confinement mode (L-mode) plasmas at the outer limiters of the first wall using calibrated visible cameras. They are inferred from the measured radiances using the spectroscopic S/XB method.
E. de la Cal, E.R. Solano, I. Balboa, S. Silburn, E. Pawelec, J. Romazanov, P. Carvalho, J. Karhunen, A. Tookey, S. Bakes, R. Chapman, J. Foster, A. Gonzalez, J. Maddock, J. Matthews, E. Pinto, I. Voldiner, L. Xiang, Y. Zayachuk, JET Contributors   +19 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Atmospheric Deposition of Multi-Class Substances into the Ocean: Synthesis of Fluxes, Seasonal Spatial Patterns and Ecological Risks

Journal of Marine Science and Engineering
Atmospheric deposition is increasingly recognized as a significant pathway transporting diverse substances from land to the ocean. However, significant uncertainties persist regarding the magnitude, spatial variability, and ecological implications of ...
Qinghao Lin, Xianliang Yi, Junyi Wang, Yiwen Zhang, Jingjing Zhan   +4 more
doaj   +1 more source

Simple water vapor sampling for stable isotope analysis using affordable valves and bags [PDF]

Atmospheric Measurement Techniques
Water-stable isotopes are commonly used in hydrological and ecological research. Until now, most measurements of soil or plant water isotopes have been made by taking a sample from the field and extracting its water in the laboratory.
A. Dahlmann, A. Dahlmann, J. D. Marshall, D. Dubbert, M. Hoffmann, M. Dubbert   +5 more
doaj   +1 more source