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Molecular Interplays of FMDV with the type I IFN Response: Importance of the model & potential links with viral persistence [PDF]

Webinar du GFRAThe December webinar was by Dr. Sandra Blaise-Boisseau, deputy head of the team “BIOPIC” in the Virology Joined research Unit (JRU) of the ANSES laboratory for animal health (Maisons-Alfort, France).
Blaise-Boisseau, Sandra
core

Inhibition of the foot-and-mouth disease virus subgenomic replicon by RNA aptamers. [PDF]

, 2014
We have previously documented the inhibitory activity of RNA aptamers to the RNA-dependent RNA polymerase of foot-and-mouth disease virus (3D(pol)). Here we report their modification and use with a subgenomic replicon incorporating GFP (pGFP-PAC replicon)
Forrest, S +11 more
core +1 more source

A genome-wide CRISPR screening uncovers that TOB1 acts as a key host factor for FMDV infection via both IFN and EGFR mediated pathways.

PLoS Pathogens
The interaction between foot-and-mouth disease virus (FMDV) and the host is extremely important for virus infection, but there are few researches on it, which is not conducive to vaccine development and FMD control.
Gaochuang Peng +11 more
doaj +1 more source

FMDV antigen detection by multi-channel immunofluorescence technique. [PDF]

, 2016
(A) FMDV antigen (red) in few cells in lungs of aborted fetus from Dam ID#454 by indirect fluorescence assay (IFA). (B) Same image as shown in panel (A) merged with nuclear staining by DAPI (blue).
Jitendra K. Biswal (3558917) +7 more
core +1 more source

TOB1 deletion prevents FMDV infection in vivo. [PDF]

A Knockout schematic representation position of the sequence for TOB1 in TOB1-/- mice. The mouse genome of TOB1 contained two exons. CRISPR/Cas9 technology was used to design a targeted vector to exon 2. B Expression and protein levels of TOB1 in TOB1-/-
Xuguang Du (8466264) +11 more
core +1 more source

Effective inhibition of foot-and-mouth disease virus (FMDV) replication in vitro by vector-delivered microRNAs targeting the 3D gene

Virology Journal, 2011
Background Foot-and-mouth disease virus (FMDV) causes an economically important and highly contagious disease of cloven-hoofed animals. RNAi triggered by small RNA molecules, including siRNAs and miRNAs, offers a new approach for controlling viral ...
Cai Xuepeng +8 more
doaj +1 more source

TOB1-knockout inhibits FMDV entry by inhibiting EGFR pathway. [PDF]

A IBRS-2 Control and TOB1-knockout IBRS-2 cells were infected with FMDV for 1 h at 4°C (left) or 30 min at 37°C (right). The FMDV RNA copies number were detected by absolute quantitative real-time PCR.
Xuguang Du (8466264) +11 more
core +1 more source

FMDV purification and characterization. [PDF]

, 2016
RNA was extracted from 400 μl of the cell culture supernatant collected from either the mock-infected or BP15 virus-infected cells, followed by transfection in BHK-21 cells.
Nitika Sharma (3167778) +13 more
core +1 more source

FMDV interferes with MoDC development in vitro. [PDF]

, 2013
A. Dot plots show forward scatter (FSC) and side scatter (SSC) for uninfected, FMDV-infected at D0 and FMDV-infected at D5 before TNF-α stimulation (−TNF-α) and upon TNF-α treatment (+TNF-α).
Noemí Sevilla (317977) +3 more
core +1 more source

Cmss1 limits FMDV infection by enhancing antigen presentation and CD8+ T cell responses

Journal of Virology
The foot and mouth disease virus (FMDV) poses a heavy burden on the global swine industry, underscoring the urgent need for long-term protective vaccines to control FMDV infection.
Yang Wang +8 more
doaj +1 more source

foot-and-mouth disease virus
cattle
fmd

foot-and-mouth disease
allergy
immunologic diseases

serotype o
rt-pcr
pathogenesis