Results 91 to 100 of about 17,078 (200)

P2Y11 Purinoceptor Mediates the ATP-Enhanced Chemotactic Response of Rat Neutrophils

Journal of Pharmacological Sciences, 2012
ATP and hydrolysis products of ATP like adenosine regulate the chemotaxis of neutrophils by activating purinoceptors and adenosine receptors. The present study was designed to examine exogenous ATP, activation of purinoceptors, and activation of A3 ...
Feras Alkayed, Masanori Kashimata, Noriko Koyama, Toru Hayashi, Yasuo Tamura, Yukio Azuma   +5 more
doaj   +1 more source

Peripheral neutrophil functions and cell signalling in crohn's disease [PDF]

, 2013
The role of the innate immunity in the pathogenesis of Crohn's disease (CD), an inflammatory bowel disease, is a subject of increasing interest.
Fuhler, G.M. (Gwenny), Kuipers, E.J. (Ernst), Nuij, V.J.A.A. (Veerle), Peppelenbosch, M.P. (Maikel), Somasundaram, R. (Rajesh), Woude, C.J. (Janneke) van der   +5 more
core   +5 more sources

Scar Inhibition in Wound Healing: Mechanisms, Design, and Recent Advances

Exploration, Volume 6, Issue 1, February 2026.
This review elaborates on current research on immune modulation in tissue regeneration, emphasizing the roles of proinflammatory and anti‐inflammatory cells. This review also explored the potential of biomaterials for modulating the wound environment to promote scarless healing.
Yong Kang, Yiwen Yang, Bin Yao, Zhuhong Zhang, Xiaoyuan Ji   +4 more
wiley   +1 more source

TRPC1 regulates fMLP-stimulated migration and chemotaxis of neutrophil granulocytes

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2015
Neutrophils form the first line of defense of the innate immune system and are rapidly recruited by chemotactic signals to sites of inflammation. Understanding the mechanisms of neutrophil chemotaxis is therefore of great interest for the potential development of new immunoregulatory therapies.
Lindemann, O., Strodthoff, C., Horstmann, M., Nielsen, N., Jung, F., Schimmelpfennig, S., Heitzmann, M., Schwab, A.   +7 more
openaire   +2 more sources

IgE to Galactose‐α‐1,3‐Galactose (α‐Gal) and Relevance to Ustekinumab First‐Dose Infusion Reactions and Allergenicity

JGH Open, Volume 10, Issue 2, February 2026.
ABSTRACT Aims Ustekinumab, a monoclonal antibody (mAb) used to treat inflammatory bowel disease, has been associated with immediate hypersensitivity reactions during first intravenous infusion. While rare, the mechanism for these reactions is unclear. IgE to the oligosaccharide galactose‐α‐1,3‐galactose (α‐gal) is a cause of allergy to mammalian meat ...
Preethi G. Venkat, Jill F. Nehrbas, Pamela Schoppee Bortz, Thomas A. Platts‐Mills, Brian W. Behm, Esteban J. Figueroa, Jeffrey M. Wilson   +6 more
wiley   +1 more source

Dysregulation of Farnesoid X Receptor on Neutrophil Homeostasis Exacerbates Intestinal Inflammation via the mTORC1‐Glycolysis Signaling Pathway

MedComm, Volume 7, Issue 2, February 2026.
FXR signaling attenuates neutrophil functions by suppressing mTORC1 activity to ameliorate intestinal mucosal inflammation in IBD. In the inflamed intestinal mucosa, FXR expression is markedly diminished in neutrophils, attenuating its restraint on the mTORC1‐glycolysis axis. This metabolic shift toward elevated glycolysis augments neutrophil migratory
Dengfeng Kang, Ai Li, Xiangqi Xie, Han Liu, Liang Chen, Zhongsheng Feng, Xiang Gao, Han Gao, Xiaohan Wu, Huiying Lu, Xiaoyu Li, Jinghan Hua, Long Ju, Haifeng Lian, Xue Li, Zhanju Liu   +15 more
wiley   +1 more source

Shape oscillations of human neutrophil leukocytes: characterization and relationship to cell motility [PDF]

, 1996
When neutrophil leukocytes are stimulated by chemotactic factors or by substratum contact, they change their shape. Shape changes are a prerequisite for cellular migration and typically involve the extrusion of thin, veil-like lamellipods and the ...
Coates, Thomas D., Deranleau, David A., Ehrengruber, Markus U.   +2 more
core  

New Flavones, a 2-(2-Phenylethyl)-4H-chromen-4-one Derivative, and Anti-Inflammatory Constituents from the Stem Barks of Aquilaria sinensis

Molecules, 2015
In the current study, two new flavones, 4′-O-geranyltricin (1) and 3′-O-geranylpolloin (2), and a new 2-(2-phenylethyl)-4H-chromen-4-one derivative, 7-hydroxyl-6-methoxy-2-(2-phenylethyl)chromone (3), have been isolated from the stem barks of A. sinensis,
Sin-Ling Wang, Tsong-Long Hwang, Mei-Ing Chung, Ping-Jyun Sung, Chih-Wen Shu, Ming-Jen Cheng, Jih-Jung Chen   +6 more
doaj   +1 more source

Influence of Granulocytes on Brain Edema, Intracranial Pressure, and Cerebrospinal Fluid Concentrations of Lactate and Protein in Experimental Meningitis [PDF]

, 2017
Brain water content (brain edema), intracranial pressure, and cerebrospinal fluid (CSF) concentrations of lactate and protein increased significantly during 24 h of experimental meningitis due to Streptococcus pneumoniae, but changes were similar in ...
Borschberg, Urs, Sande, Merle A., Täuber, Martin G.   +2 more
core  

New Anti-Inflammatory Aporphine and Lignan Derivatives from the Root Wood of Hernandia nymphaeifolia

Molecules, 2018
A new aporphine, 3-hydroxyhernandonine (1) and a new lignin, 4′-O-demethyl-7-O-methyldehydropodophyllotoxin (2), have been isolated from the root wood of Hernanadia nymphaeifolia, together with thirteen known compounds (3–15).
Chuan-Yen Wei, Shih-Wei Wang, Jin-Wang Ye, Tsong-Long Hwang, Ming-Jen Cheng, Ping-Jyun Sung, Tsung-Hsien Chang, Jih-Jung Chen   +7 more
doaj   +1 more source