Results 171 to 180 of about 17,078 (200)

Thermal Regulation of FMLP Receptors on Human Neutrophils

Journal of Leukocyte Biology, 1989
Abstract Polymorphonuclear leukocytes (PMNs) from subjects diagnosed as having iuvenile periodontitis (JP) have been categorized on the basis of their chemotactic (CTX) response to f-met-leu-phe (FMLP) when assayed concurrently with PMNs from periodon-tally healthy subjects (HP).
R B, Coles, R R, Ranney, R J, Freer, R A, Carchman   +3 more
openaire   +2 more sources

Modeling of Granulocyte Cytoskeletal Responses Following fMLP Challenging

Immunopharmacology and Immunotoxicology, 2007
Formyl peptides released from Gram-negative bacteria ligate a group of specific mammalian receptors, expressed mainly on granulocytes, monocytes, and macrophages. Receptor ligation activates different transduction cascades, eventually leading to the release of reactive oxygen species and other bactericidal chemical species, and the activation of the ...
PANARO, Maria Antonietta, CIANCIULLI, ANTONIA, LISI, SABRINA, SISTO, MARGHERITA, ACQUAFREDDA A, MITOLO CI, CAVALLO P, MITOLO V.   +7 more
openaire   +3 more sources

Cellular Responses to Fmlp Challenging: A Mini-Review

Immunopharmacology and Immunotoxicology, 1999
FMLP (N-formyl-methionyl-leucyl-phenylalanine) and other N-formylpeptides are powerful "activators" of polymorphonuclear and mononuclear phagocytes, but they are also active on other cell types. Present knowledge about formylpeptide receptors and the relevant tools for their imaging and the study of their dynamics are briefly discussed.
PANARO, Maria Antonietta, MITOLO V.
openaire   +2 more sources

Structural simplification of FMLP

Proceedings. 2005 International Conference on Communications, Circuits and Systems, 2005., 2005
The number of fuzzy rules directly determines the complexity and efficiency of a fuzzy multilayer perceptron (FMLP). Based on the neural network self-configuring learning (NNSCL) algorithm, the NNSCL-I algorithm is obtained by using the generalized inverse matrix (GIM) algorithm to adjust the remaining weights after pruning neurons.
openaire   +1 more source

Larixol Inhibits Fmlp-Induced Superoxide Anion Production and Chemotaxis by Targeting the Βγ Subunit of Gi-Protein of Fmlp Receptor in Human Neutrophils

SSRN Electronic Journal, 2022
The over-activated neutrophils through G-protein-coupled receptors (GPCRs) caused inflammation or tissue damage. Therefore, GPCRs or their downstream molecules are major targets for inhibiting uncontrolled neutrophil activation. Our studies investigate the action and underlying mechanism of larixol, a diterpene extract from the root of euphorbia ...
Hsiang-Ruei, Liao, Yu-Yao, Kao, Yann-Lii, Leu, Fu-Chao, Liu, Ching-Ping, Tseng   +4 more
openaire   +2 more sources

Inhaled FMLP increases microvascular permeability in the rabbit trachea

Journal of Applied Physiology, 1993
This study was designed to determine the effect of inhaled N-formyl-methionyl-leucyl-phenylalanine (FMLP) on microvascular permeability in the rabbit trachea and to determine if the effect could be modified by cholinergic antagonism, neutral endopeptidase (NEP) inhibition, opioid receptor antagonism, or an opioid agonist.
Bell, S.C., Rynell, A.-C., Matheson, M.J., Finnimore, A.J., Berend, N.   +4 more
openaire   +2 more sources

fMLP provokes coronary vasoconstriction and myocardial ischemia in rabbits

American Journal of Physiology-Heart and Circulatory Physiology, 1988
Recent pathological studies of coronary arteries from humans with suspected coronary spasm have revealed an augmented intramural burden of inflammatory cells. To test the hypothesis that inappropriate activation of inflammatory cells participates in the evolution of coronary vasospasm, the present experiments employed a newly developed coronary ...
M N, Gillespie, D C, Booth, B J, Friedman, M R, Cunningham, M, Jay, A N, DeMaria   +5 more
openaire   +2 more sources

FMLP-activated neutrophils evoke histamine release from mast cells

Agents and Actions, 1986
Human neutrophils, having been activated by the chemotactic peptide N-formylmethionyl-leucyl-phenylalanine (FMLP), evoke histamine release from rat serosal mast cells. The release is dependent on FMLP concentration and it can be inhibited by disodium cromoglycate and by a flavonoid, silymarin, which displays free radical scavenging properties ...
FANTOZZI, Roberto, Brunelleschi S., Rubino A., Tarli S., Masini E., Mannaioni P. F.   +5 more
openaire   +4 more sources

PepT1-mediated fMLP transport induces intestinal inflammation in vivo

American Journal of Physiology-Cell Physiology, 2002
In the present study, the effect of H+/peptide transporter (PepT1)-mediated N-formylmethionyl-leucyl-phenylalanine (fMLP) transport on inflammation in vivo in the rat small intestine, which expresses high PepT1 levels, and in the rat colon, which does not express PepT1, were investigated using myeloperoxidase (MPO) activity and histological analysis ...
Marion, Buyse, Annick, Tsocas, Francine, Walker, Didier, Merlin, Andre, Bado   +4 more
openaire   +2 more sources

Taxol inhibits N-formyl-methionyl-leucyl-phenylalanine (FMLP)-induced human neutrophil polarization and H2O2 production while decreasing [3H]FMLP binding

Agents and Actions, 1987
We have studied the effect of taxol on two N-formyl-methionyl-leucyl-phenylalanine (FMLP)-induced neutrophil functions and the possible mechanism by which it inhibits these functions. Taxol inhibited FMLP-induced human neutrophil polarization (a characteristic change in neutrophil shape in response to a chemotactic stimulus) and H2O2 generation.
M A, Iannone, G, Wolberg, R, Reynolds-Vaughn, T P, Zimmerman   +3 more
openaire   +2 more sources