Results 11 to 20 of about 17,078 (200)

Clathrin-mediated endocytosis regulates fMLP-mediated neutrophil polarization [PDF]

Heliyon, 2018
A cell's ability to establish polarization is one of the key steps in directional migration. Upon the addition of a chemoattractant, N-formylmethionyl-leucyl-phenylalanine (fMLP), neutrophils rapidly develop a front end marked by a wide and dense actin ...
Xinyu Tan, Mingzhi Luo, Allen P. Liu
doaj   +3 more sources

Prolyl-Isomerase Pin1 Controls Key fMLP-Induced Neutrophil Functions [PDF]

Biomedicines, 2021
Neutrophils are key cells of the innate immune and inflammatory responses. They are the first blood cells to migrate to the infection site where they release high amounts of reactive oxygen species (ROS) and several peptides and enzymes required for ...
Samia Bedouhene, Min Liu, Nassima Senani, Tarek Boussetta, Coralie Pintard, Pham My-Chan Dang, Jamel El-Benna   +6 more
doaj   +4 more sources

Polyphenolic Activation of Basophils Explains Alcohol Hypersensitivity in AERD. [PDF]

Laryngoscope
The mechanism behind alcohol sensitivity in AERD has not been previously characterized. This study demonstrates the activation of basophils in patients with CRSwNP and AERD by polyphenolic compounds, but not ethanol. Since these compounds can be found in alcoholic beverages in similar frequencies by which they trigger symptoms, this research provides a
Payne SC, Eschenbacher W, Stepp R, Borish L.   +3 more
europepmc   +2 more sources

Eosinophils do respond to fMLP [PDF]

Blood, 1987
Abstract Eosinophils were isolated from normal human blood by separation over Percoll gradients, which resulted in eosinophil suspensions of a purity higher than 95% and recoveries of about 65%. Normal human eosinophils were found to respond to formyl-methionyl-leucyl-phenylalanine (fMLP) at concentrations greater than 10(-7) mol/L with ...
M, Yazdanbakhsh, C M, Eckmann, L, Koenderman, A J, Verhoeven, D, Roos   +4 more
openaire   +2 more sources

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

MLK3 regulates fMLP-stimulated neutrophil motility [PDF]

Molecular Immunology, 2014
Mixed lineage kinase 3 (MLK3) is part of the intracellular regulatory system that connects extracellular cytokine or mitogen signals received through G-protein coupled receptors to changes in gene expression. MLK3 activation stimulates motility of epithelial cells and epithelial-derived tumor cells, but its role in mediating the migration of other cell
Oksana, Polesskaya, Christopher, Wong, Luis, Lebron, Jeffrey M, Chamberlain, Harris A, Gelbard, Val, Goodfellow, Minsoo, Kim, John L, Daiss, Stephen, Dewhurst   +8 more
openaire   +2 more sources

Neutrophil chemotaxis in moving gradients of fMLP [PDF]

Journal of Leukocyte Biology, 2000
Abstract In this study the fluid gradient chamber, a modified version of the Boyden chamber that enables mobile gradients, was used to study the migration of human granulocytes in gradients of fMLP. Temporal chemotactic gradients were created by moving density-stabilized spatial gradients at different velocities in relation to migrating ...
P R, Ebrahimzadeh, C, Högfors, M, Braide   +2 more
openaire   +2 more sources

Absence of FMLP Receptors on Rat Macrophages [PDF]

Journal of Leukocyte Biology, 1991
Abstract Although rat peritoneal neutrophils in the presence of cytochalasin B demonstrate superoxide (O2-) responses to the chemotactic peptide N'-formyl-met-leu-phe (FMLP), neither elicited rat peritoneal macrophages nor rat alveolar macrophages show an O2-response to FMLP (in the presence or absence of cytochalasin B), although a good
Walker, Blair A.M., Seiler, Andrew J., Owens, Catherine A., Hagenlocker, Brian E., Ward, Peter A.   +4 more
openaire   +3 more sources

Pertussis Toxin-sensitive Activation of Phospholipase C by the C5a and fMet-Leu-Phe Receptors [PDF]

, 1996
Signal transduction pathways that mediate C5a and fMet-Leu-Phe (fMLP)-induced pertussis toxin (PTx)-sensitive activation of phospholipase C (PLC) have been investigated using a cotransfection assay system in COS-7 cells.
Jiang, Huiping, Kuang, Yanan, Simon, Melvin I., Smrcka, Alan, Wu, Dianqing, Wu, Yanping   +5 more
core   +1 more source

Intracapillary leucocyte accumulation as a novel antihaemorrhagic mechanism in acute pancreatitis in mice [PDF]

, 2009
Background: Pancreatic infiltration by leucocytes represents a hallmark in acute pancreatitis. Although leucocytes play an active role in the pathophysiology of this disease, the relation between leucocyte activation, microvascular injury and haemorrhage
Deduchovas, O., Hartwig, W., Kerkadze, V., Märten, A., Parseliunas, A., Ryschich, E., Salnikova, O., Schmidt, J., Sperandio, Markus   +8 more
core   +1 more source