Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo. [PDF]
, 2011 Based on its capacity to inhibit in vitro HIV-1 replication in T cells and the release of pro-inflammatory cytokines in monocytes, the prenylated heterodimeric phloroglucinyl α-pyrone arzanol was identified as the major anti-inflammatory and anti-viral ...
Appendino G +8 more
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Journal of Pharmacological Sciences, 2008 Although cyclic ADP-ribose (cADPR), a novel Ca2+-mobilizing mediator, is suggested to be involved in the functions of neutrophils in rodents, its role in human neutrophils remains unclear.
Katsuya Morita +5 more
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Advanced Science, 2022 Inflammation plays a crucial role in triggering regeneration, while inadequate or chronic inflammation hinders the regenerative process, resulting in refractory wounds.
Xuemei Liu +17 more
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A role for Syk-kinase in the control of the binding cycle of the β2 integrins (CD11/CD18) in human polymorphonuclear neutrophils [PDF]
, 2003 A fine control of β2 integrin (CD11/CD18)-mediated firm adhesion of human neutrophils to the endothelial cell monolayer is required to allow ordered emigration.
Arnaout +47 more
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Bacterial fMLP Modulates Both ROS and Chemotaxis [PDF]
Scandinavian Journal of Immunology, 2017 I have recently read an article entitled,” Bacterial N-formyl Peptides Reduce PMA- and E.coli-induced Neutrophil Respiratory Burst in Term Neonates and Adults” by Stalhammar et al. published in the Scandinavian Journal of Immunology[1]. The paper nicely showed that fMLP at higher doses (>1nM) reduces the amount of ROS generated thus it may alter the ...
openaire +2 more sources
1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells. [PDF]
, 1984 The human-derived promyelocytic leukemia cell line, HL-60, is known to differentiate into mature myeloid cells in the presence of 1,25-dihydroxyvitamin D3 (1,25[OH]2D3).
Donaldson, CA +5 more
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⁹⁹ᵐTc SPECT imaging agent based on cFLFLFK for the detection of FPR1 in inflammation [PDF]
, 2015 Non-invasive imaging of the inflammatory process can provide a great deal of insight into a wide variety of diseases states, aiding diagnosis, evaluation and effective targeted treatment. During inflammation, blood borne leukocytes are recruited, through
Gavins, Felicity N.E. +7 more
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Mediators of Inflammation, 1993 The selective enzyme inhibitors genistein and Ro 31-8220 were used to assess the importance of protein tyrosine kinase (PTK) and protein kinase C (PKC), respectively, in N-formyl-methionyl-leucyl-phenylalanine (FMLP) induced generation of superoxide ...
K. Pollock, M. T. Withnall
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Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus Egg Extracts Requires Binding of ATRIP to ATR but Not the Stable DNA-binding or Coiled-coil Domains of ATRIP [PDF]
, 2005 ATR, a critical regulator of DNA replication and damage checkpoint responses, possesses a binding partner called ATRIP. We have studied the functional properties of Xenopus ATR and ATRIP in incubations with purified components and in frog egg extracts ...
Dunphy, William G. +3 more
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Theoretical Properties of Projection Based Multilayer Perceptrons with Functional Inputs [PDF]
, 2006 Many real world data are sampled functions. As shown by Functional Data Analysis (FDA) methods, spectra, time series, images, gesture recognition data, etc.
A. R. Barron +38 more
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