Time course of chemotaxis and chemokinesis of neutrophils following stimulation with IL-8 or FMLP
European Journal of Inflammation, 2018 Polymorphonuclear cells (PMNs) attend to inflammatory sites by chemotactic movement, caused by chemoattractants (CAs) like n-formyl-l-methionyl-l-leucyl-l-phenylalanine (FMLP) and interleukin-8 (IL-8).
Matthias Hattenkofer +5 more
doaj +1 more source
Neutrophils in chronic lymphocytic leukemia are permanently activated and have functional defects [PDF]
, 2017 A growing body of studies highlights involvement of neutrophils in cancer development and progression. Our aim was to assess the phenotypic and functional properties of circulating neutrophils from patients with chronic lymphocytic leukemia (CLL).
Gabčová, Gabriela +10 more
core +1 more source
Dissociations in the effects of β2-adrenergic receptor agonists on cAMP formation and superoxide production in human neutrophils: support for the concept of functional selectivity. [PDF]
PLoS ONE, 2013 In neutrophils, activation of the β2-adrenergic receptor (β2AR), a Gs-coupled receptor, inhibits inflammatory responses, which could be therapeutically exploited. The aim of this study was to evaluate the effects of various β2AR ligands on adenosine-3',5'
Irena Brunskole Hummel +6 more
doaj +1 more source
Impaired neutrophil directional chemotactic accuracy in chronic periodontitis patients [PDF]
, 2015 Aim: To investigate the chemotactic accuracy of peripheral blood neutrophils from patients with chronic periodontitis compared with matched healthy controls, before and after non-surgical periodontal therapy.
Agarwal +72 more
core +2 more sources
Modulation of neutrophil chemotaxis by Aggregatibacter actinomycetemcomitans leukotoxin
Journal of Oral Microbiology, 2017 Objective: Aggressive periodontitis (AgP) is frequently associated with the presence of Aggregatibacter actinomycetemcomitans, a Gram-negative pathogen, which expresses leukotoxin (Ltx) as a virulence factor.
Josefine Hirschfeld +3 more
doaj +1 more source
BMC Musculoskeletal Disorders, 2023 Background Displaced lateral malleolus fractures are typically stabilised through open reduction and internal fixation. The biomechanically and clinically efficacy of locking plates and lag screws, particularly in Weber A and B distal fibular fractures ...
Shuming Huang +7 more
doaj +1 more source
Biomedicines, 2023 Recruitment to the local tissue and alerted phenotype are the hallmarks of basophils in chronic urticaria (CU). Chemokine receptors such as chemokine (C-C motif) receptor 4 (CCR4) or CCR8 have been studied in skin diseases, e.g., atopic dermatitis, but ...
Ewa A. Bartko +4 more
doaj +1 more source
Lewis X antigen mediates adhesion of human breast carcinoma cells to activated endothelium. Possible involvement of the endothelial scavenger receptor C-Type lectin [PDF]
, 2007 Lewis x (Lex, CD15), also known as SSEA-1 (stage specific embryonic antigen-1), is a trisaccharide with the structure Galβ(1–4)Fucα(1–3)GlcNAc, which is expressed on glycoconjugates in human polymorphonuclear granulocytes and various tumors such as colon
A Hittelet +51 more
core +1 more source
Differential fMet-Leu-Phe- and Platelet-activating Factor-induced Signaling Toward Ral Activation in Primary Human Neutrophils [PDF]
, 1999 We have measured the activation of the small GTPase Ral in human neutrophils after stimulation with fMet- Leu-Phe (fMLP), platelet activating factor (PAF), and granulocyte macrophage-colony stimulating factor and compared it with the activation of ...
Bos, J.L. +5 more
core +5 more sources
fMLP-Induced IL-8 Release Is Dependent on NADPH Oxidase in Human Neutrophils
Journal of Immunology Research, 2015 N-Formyl-methionyl-leucyl-phenylalanine (fMLP) and platelet-activating factor (PAF) induce similar intracellular signalling profiles; but only fMLP induces interleukin-8 (IL-8) release and nicotinamide adenine dinucleotide phosphate reduced (NADPH ...
María A. Hidalgo +6 more
doaj +1 more source