Results 61 to 70 of about 17,078 (200)

Differential neutrophil chemotactic response towards IL-8 and bacterial N-formyl peptides in term newborn infants

Upsala Journal of Medical Sciences, 2017
Background: A prerequisite for an effective innate immunity is the migrative ability of neutrophils to respond to inflammatory and infectious agents such as the intermediate interleukin (IL)-8 and the end-target formyl-methionyl-leucyl-phenylalanine ...
Maria E. Stålhammar, Lena Douhan Håkansson, Anders Jonzon, Richard Sindelar   +3 more
doaj   +1 more source

Spleen tyrosine kinase Syk is critical for sustained leukocyte adhesion during inflammation in vivo

BMC Immunology, 2007
Background During inflammation, β2-integrins mediate leukocyte adhesion to the endothelium accompanied by the activation of the spleen tyrosine kinase Syk.
Poeschl Johannes, Mocsai Attila, Schymeinsky Jürgen, Mannigel Ingrid, Frommhold David, Walzog Barbara, Sperandio Markus   +6 more
doaj   +1 more source

Mas-related G protein-coupled receptor MRGPRX2 in human basophils: Expression and functional studies

Frontiers in Immunology, 2023
BackgroundOccupancy of MRGPRX2 heralds a new era in our understandings of immediate drug hypersensitivity reactions (IDHRs), but a constitutive expression of this receptor by basophils is debated.ObjectiveTo explore the expression and functionality of ...
Alessandro Toscano, Alessandro Toscano, Alessandro Toscano, Jessy Elst, Jessy Elst, Athina L. Van Gasse, Athina L. Van Gasse, Athina L. Van Gasse, Athina L. Van Gasse, Michiel Beyens, Michiel Beyens, Marie-Line van der Poorten, Marie-Line van der Poorten, Marie-Line van der Poorten, Marie-Line van der Poorten, Chris H. Bridts, Chris H. Bridts, Christel Mertens, Christel Mertens, Michel Van Houdt, Michel Van Houdt, Margo M. Hagendorens, Margo M. Hagendorens, Margo M. Hagendorens, Margo M. Hagendorens, Samuel Van Remoortel, Jean-Pierre Timmermans, Didier G. Ebo, Didier G. Ebo, Didier G. Ebo, Vito Sabato, Vito Sabato, Vito Sabato   +32 more
doaj   +1 more source

Gender and Land Degradation Neutrality (LDN): Evaluating Nigeria's Legislative Framework for Achieving Gender‐Equitable LDN Outcomes

Land Degradation &Development, EarlyView.
ABSTRACT Legislative frameworks that support gender equality are crucial for addressing structural inequalities, protecting women's rights, and achieving gender‐equitable land degradation neutrality (LDN) outcomes. This study examines the extent to which national‐level policies and legislation governing LDN and related sectors incorporate gender ...
Cynthia Nneka Olumba, Chukwudi Charles Olumba   +1 more
wiley   +1 more source

Sequence of Immunological Events During IgE‐Mediated Allergic Reactions to Food

Allergy, EarlyView.
ABSTRACT Food allergies (FA) represent a significant global health burden. Upon allergen re‐exposure, allergic patients exhibit a sequence of symptoms that vary in terms of affected organ systems, severity, time of onset and allergen reactivity thresholds.
N. A. Nagy, D. Schnoegl, V. Houghton, L. O'Mahony, A. F. Santos, E. F. Knol, A. Kuehn, T. Eiwegger   +7 more
wiley   +1 more source

N-formylmethionine-leucyl-phenylalanine protects against irradiation-induced damage to hematopoiesis and intestines

Molecular Medicine
Background Ionizing radiation (IR), including radiotherapy, can exert lasting harm on living organisms. While liposaccharide (LPS) offers resistance to radiation damage, it also induces toxic responses.
Zhihua Li, Yatong Wu, Jicong Du, Wen Qian, Sinian Wang, Fengsheng Li, Suhe Dong, Shunchang Jiao   +7 more
doaj   +1 more source

Class-IA Phosphoinositide 3-Kinase p110β Triggers GPCR-Induced Superoxide Production in p110γ-Deficient Murine Neutrophils

Journal of Pharmacological Sciences, 2012
Studies with knockout mice have indicated that the only isoform of phosphoinositide 3-kinase (PI3K) functioning in the oxidative burst of mouse neutrophils in response to heterotrimeric guanine nucleotide-binding protein–coupled receptor (GPCR) agonists ...
Kiyomi Nigorikawa, Kaoru Hazeki, Takashi Kumazawa, Yuhta Itoh, Megumi Hoshi, Osamu Hazeki   +5 more
doaj   +1 more source

Neutrophil chemotaxis in cord blood of term and preterm neonates is reduced in preterm neonates and influenced by the mode of delivery and anaesthesia. [PDF]

PLoS ONE, 2015
Bacterial infections, even without any perinatal risk factors, are common in newborns, especially in preterm neonates. The aim of this study was to evaluate possible impairment of neutrophil chemotaxis in term and preterm neonates compared with adults as
Alexandra Birle, C Thomas Nebe, Sandra Hill, Karin Hartmann, Johannes Poeschl, Lutz Koch   +5 more
doaj   +1 more source

AllergoOncology in Review: Harnessing Allergy in the Field of Oncology to Improve Patient Outcomes

Clinical &Experimental Allergy, EarlyView.
ABSTRACT The AllergoOncology field brings together the study of allergic and cancer immune responses, having evolved from early epidemiological studies that reported inverse associations between allergies, IgE and cancer risk. Insights from studying allergic inflammation are revealing previously unappreciated immune mechanisms that confer protective ...
Jakub Zydron, Anishaa Balaji, Jitesh Chauhan, Jack Alder, Xinyi Chen, Anna M. F. Wiegman, Aurelie Poli, Joanna Jacków‐Malinowska, Jack Cheeseman, Daniel I. R. Spencer, James McDonnell, James Spicer, Alexandra J. McCraw, Sophia N. Karagiannis   +13 more
wiley   +1 more source

A Microfluidic Platform for Evaluating Neutrophil Chemotaxis Induced by Sputum from COPD Patients.

PLoS ONE, 2015
Chronic Obstructive Pulmonary Disease (COPD) is a common lung disease characterized by breathing difficulty as a consequence of narrowed airways. Previous studies have shown that COPD is correlated with neutrophil infiltration into the airways through ...
Jiandong Wu, Craig Hillier, Paul Komenda, Ricardo Lobato de Faria, David Levin, Michael Zhang, Francis Lin   +6 more
doaj   +1 more source