Results 111 to 120 of about 6,156 (251)

Fibronectin type III domain-containing protein 5 interacts with APP and decreases amyloid β production in Alzheimer’s disease

Molecular Brain, 2018
The deposition of Amyloid-beta peptides (Aβ) is detected at an earlier stage in Alzheimer’s disease (AD) pathology. Thus, the approach toward Aβ metabolism is considered to play a critical role in the onset and progression of AD.
Yasuha Noda, Akira Kuzuya, Kyousuke Tanigawa, Mitsugu Araki, Ryoko Kawai, Biao Ma, Yoko Sasakura, Masato Maesako, Yoshitaka Tashiro, Masakazu Miyamoto, Kengo Uemura, Yasushi Okuno, Ayae Kinoshita   +12 more
doaj   +1 more source

Laser-scanning cytometry can quantify human adipocyte browning and proves effectiveness of irisin [PDF]

, 2015
Laser-scanning cytometry is presented as a tool allowing population scale analysis of ex vivo human brown adipogenic differentiation. It combines texture analysis and detection of Ucp1 protein content in single brown adipocytes of mixed cell populations ...
Bacso, Zsolt, Bai Péter (1976-) (biokémikus), Bai, Péter, Doan-Xuan, Quang-Minh, Fésüs, László, Kristóf, Endre   +5 more
core   +1 more source

Early sensorimotor restriction in rats induces age‐dependent mitochondrial alterations in skeletal muscles and brain structures

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to determine whether early sensorimotor restriction (SMR) alters mitochondrial enzyme activities in rat muscles and brain structures. SMR was induced via immobilizing the hind limbs of pups for 16 h per day during the dark phase from birth to postnatal day (PND) 28.
Mélanie Van Gaever, Olivier Dupuy, Erwan Dupont, Marie‐Hélène Canu, Frederic Daussin   +4 more
wiley   +1 more source

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

Nature Network Boston, 2018
Defective brain hormonal signaling has been associated with Alzheimer’s disease (AD), a disorder characterized by synapse and memory failure. Irisin is an exercise-induced myokine released on cleavage of the membrane-bound precursor protein fibronectin ...
Mychael V. Lourenco, R. Frozza, G. B. de Freitas, Hong Zhang, G. C. Kincheski, F. Ribeiro, R. A. Gonçalves, J. Clarke, Danielle Beckman, Agnieszka Staniszewski, Hanna Berman, Lorena A. Guerra, Letícia Forny‐Germano, Shelby Meier, D. Wilcock, Jorge M. de Souza, S. Alves‐Leon, V. Prado, M. Prado, J. Abisambra, F. Tovar-Moll, P. Mattos, O. Arancio, S. Ferreira, F. D. De Felice   +24 more
semanticscholar   +1 more source

Comparative Genomic Characterization of Buffalo Fibronectin Type III Domain Proteins: Exploring the Novel Role of FNDC5/Irisin as a Ligand of Gonadal Receptors

Biology, 2021
FN-III proteins are widely distributed in mammals and are usually involved in cellular growth, differentiation, and adhesion. The FNDC5/irisin regulates energy metabolism and is present in different tissues (liver, brain, etc.).
Siwen Wu, Faiz-ul Hassan, Yuhong Luo, Israr Fatima, Ishtiaq Ahmed, Awais Ihsan, Warda Safdar, Qingyou Liu, Saif ur Rehman   +8 more
doaj   +1 more source

Concomitant Increases in Brain‐Derived Neurotrophic Factor and Lactate Post‐Exercise Do Not Demonstrate a Direct Correlation

Journal of Neuroscience Research, Volume 103, Issue 6, June 2025.
While BDNF and lactate concentrations are responsive to a submaximal graded exercise test in a healthy population, lactate cannot be used as an alternative to BDNF and subsequently may not be an indication of BDNF‐associated neuroplasticity. ABSTRACT The aim of this study was to determine the relationship between BDNF and lactate concentration ...
S. K. Ashcroft, K. Basclain, C. Woolnough, M. W. Hoon, S. J. Walsh, L. C. Starc, L. Johnson, S. S. Kuys, A. G. Thompson‐Butel   +8 more
wiley   +1 more source

Urotensin II Induces Mice Skeletal Muscle Atrophy Associated with Enhanced Autophagy and Inhibited Irisin Precursor (Fibronectin Type III Domain Containing 5) Expression in Chronic Renal Failure

Kidney & Blood Pressure Research, 2019
Background/Aims: Skeletal muscle atrophy is one of the main manifestations of protein energy wasting. We hypothesized that urotensin II (UII) can lead to skeletal muscle atrophy through upregulating autophagy and affecting Irisin precursor fibronectin ...
Ya-Jing Pan, Si-Jia Zhou, Jin Feng, Qiong Bai, La-Ta A, Ai-Hua Zhang   +5 more
doaj   +1 more source

The effects of acetylsalicylic acid on performance, carcass traits, breast meat quality and white striping muscle defects in broiler chickens

Journal of the Science of Food and Agriculture, Volume 105, Issue 8, Page 4338-4348, June 2025.
Abstract BACKGROUND This research aims to reduce white striping muscle defects induced by vascular inflammation and hypoxia using the anti‐inflammatory, antiplatelet and anti‐atherothrombotic properties of acetylsalicylic acid (ASA). To this end, the effects of different doses (0.3, 0.6, 1, 3 and 6 g L−1) of ASA added to drinking water at 24–48 days on
Gülşah Güngören, Ulku Gulcihan Simsek, Alper Güngören, Mehmet Çiftçi, Hatice Eröksüz, Burak Karabulut, Yasin Baykalir, Mücahit Kahraman, İsmail Demircioğlu, Şermin Top   +9 more
wiley   +1 more source

Effects of the VIVIFRAIL Exercise Protocol on Circulatory and Intracellular Peripheral Mediators Bridging Mitochondrial Dynamics and Inflammation in Robust and Frail Older People

Aging Cell, Volume 24, Issue 6, June 2025.
Physical activity promotes functional improvements in both robust and physically frail older adults, driven by distinct adaptation mechanisms in the mitochondria‐inflammation axis that are influenced by age and frailty status. ABSTRACT Physical exercise has been associated with healthier aging trajectories, potentially preventing or mitigating age ...
Fiona Limanaqi, Evelyn Ferri, Pasquale Ogno, Franca Rosa Guerini, Gabriela Alexandra Mihali, Tiziano Lucchi, Mario Clerici, Chiara Fenoglio, Laura D'Andrea, Elena Marcello, Mara Biasin, Beatrice Arosio   +11 more
wiley   +1 more source

FNDC5/Irisin mitigates high glucose-induced neurotoxicity in HT22 cell via ferroptosis.

BioScience Trends
Diabetes-induced neuropathy represents a major etiology of dementia, highlighting an urgent need for the development of effective therapeutic interventions. In this study, we explored the role of fibronectin type III domain containing 5 (FNDC5)/Irisin in
Lingling Yang, Xiaohan Zhou, Tian Heng, Yinghai Zhu, Lihuan Gong, Na Liu, Xiuqing Yao, Yaxi Luo   +7 more
semanticscholar   +1 more source