Results 121 to 130 of about 7,212 (245)

Therapeutic potential of exercise-hormone irisin in Alzheimer’s disease

Neural Regeneration Research
Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type III domain-containing protein 5 (FNDC5) in response to physical exercise.
Eunhee Kim, Rudolph E. Tanzi, Se Hoon Choi   +2 more
doaj   +1 more source

Systematic selection of small molecules to promote differentiation of embryonic stem cells and experimental validation for generating cardiomyocytes. [PDF]

, 2016
Small molecules are being increasingly used for inducing the targeted differentiation of stem cells to different cell types. However, until now no systematic method for selecting suitable small molecules for this purpose has been presented. In this work,
Baharvand, H, Bender, A, KalantarMotamedi, Y, Nasr-Esfahani, MH, Peymani, M   +4 more
core   +2 more sources

Белая и бурая жировые ткани: взаимодействие со скелетной мышечной тканью [PDF]

, 2014
белая жировая тканьЖИРОВАЯ ТКАНЬЖИРОВАЯ ТКАНЬ БУРАЯСКЕЛЕТГИППОКАМПГОРМОНЫКАМБИАЛЬНЫЕ КЛЕТКИСТВОЛОВЫЕ КЛЕТКИМЫШЕЧНЫЕ ВОЛОКНАУМСТВЕННАЯ СПОСОБНОСТЬЧЕЛОВЕКА ...
Кичигина, Т. Н., Мяделец, В. О., Мяделец, О. Д., Соболевская, И. С.   +3 more
core  

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

Nature Medicine, 2018
Defective brain hormonal signaling has been associated with Alzheimer’s disease (AD), a disorder characterized by synapse and memory failure. Irisin is an exercise-induced myokine released on cleavage of the membrane-bound precursor protein fibronectin ...
Mychael V. Lourenco, R. Frozza, Guilherme B. de Freitas, Hong Zhang, G. C. Kincheski, F. Ribeiro, R. A. Gonçalves, J. Clarke, Danielle Beckman, Agnieszka Staniszewski, Hanna Berman, Lorena A. Guerra, Letícia Forny‐Germano, Shelby Meier, D. Wilcock, Jorge M. de Souza, S. Alves‐Leon, V. Prado, M. Prado, J. Abisambra, F. Tovar-Moll, P. Mattos, O. Arancio, S. Ferreira, F. D. De Felice   +24 more
semanticscholar   +1 more source

Irisin regulates pancreatic lipases through PPARγ-PGCα-FNDC5 pathway

Genes & Diseases, 2023
Horwitz Avital, Birk Ruth
openaire   +3 more sources

Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice

Advanced Science
Identifying the mechanistic targets of crosstalk between sarcopenia (SA) and mild cognitive impairment (MCI) is critical for screening high‐risk populations and exploring effective prevention and treatment strategies.
Xianyun Wang, Dajun Li, Xiao Ying Li, Weizhao Lu, Huini Ding, Chengyan Qi, Xuan Wang, Jing Shen, Yafei Chi, Tiantian Li, Michelle M. Dunk, Yu An, Hongmei Huang, Kang Yu, Weili Xu, Rong Xiao, Yuandi Xi   +16 more
doaj   +1 more source

Eight Weeks of High-Intensity Interval Static Strength Training Improves Skeletal Muscle Atrophy and Motor Function in Aged Rats via the PGC-1α/FNDC5/UCP1 Pathway

Clinical Interventions in Aging, 2021
Yijie Liu,1,2,* Chaoyang Guo,1,* Shuting Liu,1 Shuai Zhang,3 Yun Mao,4 Lei Fang1 1School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China; 2Institute of Rehabilitation ...
Liu Y, Guo C, Liu S, Zhang S, Mao Y, Fang L   +5 more
doaj  

Irisin Ameliorate Acute Pancreatitis and Acinar Cell Viability through Modulation of the Unfolded Protein Response (UPR) and PPARγ-PGC1α-FNDC5 Pathways

Biomolecules
Acute pancreatitis (AP) entails pancreatic inflammation, tissue damage and dysregulated enzyme secretion, including pancreatic lipase (PL). The role of irisin, an anti-inflammatory and anti-apoptotic cytokine, in AP and exocrine pancreatic stress is ...
Avital Horwitz, Ruth Birk
semanticscholar   +1 more source

Modification of reinforcement learning processes in mood disorders in asthma patients [PDF]

, 2018
Az orbitofrontális kortex (OFC) integratív funkciója kiemelkedő jelentőségű a megerősítéses tanulási döntéshozatalban: • a mediális OFC a jel-kontextus kongruencia alapján kontextuskereteket azonosít • a laterális OFC hozzáférést biztosít a ...
Szilasi, Magdolna Emma
core  

Differential mitochondrial adaptation and FNDC5 production in brown and white adipose tissue in response to cold and obesity

Obesity
Fibronectin type III domain‐containing protein 5 (FNDC5) modulates adipocyte metabolism by increasing white and brown adipose tissue (WAT and BAT) browning and activity, respectively.
Gabriela Neira, Ana Wenting Hernández-Pardos, S. Becerril, B. Ramírez, V. Valentí, R. Moncada, V. Catalán, J. Gómez-Ambrosi, M. A. Burrell, Camilo Silva, J. Escalada, G. Frühbeck, Amaia Rodríguez   +12 more
semanticscholar   +1 more source