Results 111 to 120 of about 1,259,124 (381)
Mechano-transduction: from molecules to tissues. [PDF]
, 2014 External forces play complex roles in cell organization, fate, and homeostasis. Changes in these forces, or how cells respond to them, can result in abnormal embryonic development and diseases in adults.
Dunn, Alexander R +3 more
core +2 more sources
Focal adhesion kinase and cancer.
Histology and histopathology, 2009 Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that resides at the sites of integrin clustering, known as focal adhesions. The FAK protein has a molecular mass of 125kDa and is encoded by the FAK gene located on human chromosome 8q24.
Golubovskaya1, Vita M. +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility
Cells, 2020 Paraspeckle protein 1 (PSPC1) overexpression in cancers is known to be the pro-metastatic switch of tumor progression associated with poor prognosis of cancer patients.
Hsin-Wei Jen +3 more
doaj +1 more source
The non-equilibrium thermodynamics and kinetics of focal adhesion dynamics. [PDF]
PLoS ONE, 2010 BackgroundWe consider a focal adhesion to be made up of molecular complexes, each consisting of a ligand, an integrin molecule, and associated plaque proteins.
Joseph E Olberding +3 more
doaj +1 more source
, 2007 Biochemistry and mechanics are closely coupled in cell adhesion. At sites of cell-matrix adhesion, mechanical force triggers signaling through the Rho-pathway, which leads to structural reinforcement and increased contractility in the actin cytoskeleton.
Achim Besser +14 more
core +1 more source
Glucocorticoid receptor signalling activates YAP in breast cancer [PDF]
, 2017 The Hippo pathway is an oncosuppressor signalling cascade that plays a major role in the control of cell growth, tissue homoeostasis and organ size. Dysregulation of the Hippo pathway leads to aberrant activation of the transcription co-activator YAP ...
Bertolio, Rebecca +12 more
core +3 more sources
An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma
Nature Communications, 2015 Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths globally. The identity and role of cell surface molecules driving complex biological events leading to HCC progression are poorly understood, hence representing major ...
Sayan Chakraborty +11 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Cell migration on material-driven fibronectin microenvironments [PDF]
, 2017 Cell migration is a fundamental process involved in a wide range of biological phenomena. However, how the underlying mechanisms that control migration are orchestrated is not fully understood.
Cantini, M. +4 more
core +1 more source