Results 141 to 150 of about 1,381,729 (387)

Talin1 Promotes Prostate Cancer Invasion and Metastasis via AKT Signaling and Anoikis Resistance [PDF]

, 2009
Talin1 is an integrin regulatory protein that mediates integrin interactions with the extracellular matrix (ECM). This study investigated the significance of talin1 in prostate cancer progression to metastasis in vitro and in vivo.
Natasha Kyprianou, Richard McCann, Shinichi Sakamoto   +2 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

CLASPs link focal adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover

Nature Cell Biology, 2014
Turnover of integrin-based focal adhesions (FAs) with the extracellular matrix (ECM) is essential for coordinated cell movement. In collectively migrating human keratinocytes, FAs assemble near the leading edge, grow and mature as a result of contractile
Samantha J. Stehbens, M. Paszek, Hayley Pemble, A. Ettinger, S. Gierke, Torsten Wittmann   +5 more
semanticscholar   +1 more source

The structural basis for localisation and signalling by the focal adhesion targeting domain [PDF]

, 2002
Stefan T. Arold, M. H. Hoellerer, Jörn M. Werner, Iain D. Campbell, M.E.M. Noble   +4 more
openalex   +1 more source

Data from Therapeutic Potential of Focal Adhesion Kinase Inhibition in Small Cell Lung Cancer

, 2023
Frank Aboubakar Nana, Marylène Lecocq, Maha Zohra Ladjemi, Bruno Detry, Sébastien Dupasquier, Olivier Féron, Pierre P. Massion, Yves Sibille, Charles Pilette, Sebahat Ocak   +9 more
openalex   +1 more source

Phosphorylated paxillin and FAK constitute subregions within focal adhesions [PDF]

, 2020
Michaël Bachmann, Artiom Skripka, Bernhard Wehrle‐Haller, Martin Bastmeyer   +3 more
openalex   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

RhoJ interacts with the GIT–PIX complex and regulates focal adhesion disassembly

Journal of Cell Science, 2014
RhoJ is a Rho GTPase expressed in endothelial cells and tumour cells, which regulates cell motility, invasion, endothelial tube formation and focal adhesion numbers. This study aimed to further delineate the molecular function of RhoJ.
E. Wilson, K. Leszczynska, Natalie S. Poulter, Francesca Edelmann, V. A. Salisbury, Peter J. Noy, A. Bacon, J. Rappoport, J. Heath, R. Bicknell, V. Heath   +10 more
semanticscholar   +1 more source

Supplemental Table S5 from High-throughput Chemical Screening Identifies Focal Adhesion Kinase and Aurora Kinase B Inhibition as a Synergistic Treatment Combination in Ewing Sarcoma

, 2023
Sarah Wang, Elizabeth E. Hwang, Rajarshi Guha, Allison F. O’Neill, Nicole Melong, Chansey J. Veinotte, Amy Conway Saur, Kellsey Wuerthele, Min Shen, Crystal McKnight, Gabriela Alexe, Madeleine E. Lemieux, Amy Wang, E. D. Hughes, Xin Xu, Matthew B. Boxer, Matthew D. Hall, Andrew L. Kung, Jason N. Berman, Mindy I. Davis, Kimberly Stegmaier, Brian D. Crompton   +21 more
openalex   +1 more source