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Focal Adhesion Kinase in Neuritogenesis
2007The transduction of extracellular signals through adhesion and guidance receptors into cytoskeleton reorganization underlies axon outgrowth and pathfinding decisions. The cytoplasmic protein tyrosine kinase focal adhesion kinase (FAK), a central regulator of cell motility phenomena during morphogenesis, is highly expressed in the developing nervous ...
Bonanomi D., Valtorta F.
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pp125FAK in the Focal Adhesion
1996Integrins are a large superfamily of transmembrane adhesion molecules. In many types of cultured cells, integrins are concentrated in specialized sites called focal adhesions. Integrins are capable of transducing signals to the inside of the cell, which can effect cell migration, differentiation and growth, but the signaling mechanism of integrins has ...
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Targeting FAK in anticancer combination therapies
Nature Reviews Cancer, 2021John C Dawson +2 more
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