Results 331 to 340 of about 1,381,729 (387)

Focal Adhesion

Definitions, 2020
openaire   +2 more sources

Focal adhesion assembly

Trends in Cell Biology, 1997
The GTP-binding protein Rho regulates the assembly of focal adhesions and their associated bundles of actin filaments. Two different lines of research have converged to reveal how Rho might regulate assembly of these structures. One approach has been the identification of downstream effectors of Rho, whereas the other has been the exploration of the ...
K, Burridge, M, Chrzanowska-Wodnicka, C, Zhong   +2 more
openaire   +2 more sources

Focal adhesion kinase

The International Journal of Biochemistry & Cell Biology, 1997
Focal adhesion kinase (FAK) is a member of a growing family of non-receptor protein tyrosine kinases. Though originally identified as a putative substrate for the oncogenic tyrosine kinase pp60v-src, it is now well-established that FAK tyrosine phosphorylation is induced by adhesion of cell surface integrins to extracellular matrix and by a variety of ...
openaire   +2 more sources

Mechanotransduction and focal adhesions

Cell Biology International, 2012
AbstractCellular FAs (focal adhesions) respond to internal and external mechanical stresses which make them prime candidates for mechanotransduction. Recent observations showed that the FA proteins including vinculin, FAK (FA kinase) and p130Cas are crucial for the ability of cells to transmit forces and to generate cytoskeletal tension.
openaire   +2 more sources

Environmental sensing through focal adhesions

Nature Reviews Molecular Cell Biology, 2009
Recent progress in the design and application of artificial cellular microenvironments and nanoenvironments has revealed the extraordinary ability of cells to adjust their cytoskeletal organization, and hence their shape and motility, to minute changes in their immediate surroundings. Integrin-based adhesion complexes, which are tightly associated with
Geiger, B., Spatz, J., Bershadsky, A.
openaire   +4 more sources

Focal adhesion kinase in cancer

Frontiers in Bioscience, 2003
Focal adhesion kinase (FAK) is a non-receptor cytoplasmic tyrosine kinase that transmits signals important in modulating several cell functions, including proliferation, migration, and survival. Several different types of malignant tumors have been reported to express elevated levels of FAK protein in vivo, potentially pointing to a role for FAK in ...
Timothy P, Hecker, Candece L, Gladson
openaire   +2 more sources

Focal adhesions: Structure and dynamics

Biology of the Cell, 2000
Interactions of cells with the extracellular matrix are essential for the control of tissue remodelling, cell migration, and embryogenesis. At the cell—extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where transmembrane adhesion receptors provide a structural link between the actin cytoskeleton and the
V, Petit, J P, Thiery
openaire   +2 more sources

Focal adhesion dynamics in cellular function and disease.

Cellular Signalling, 2021
Yasaswi Gayatri Mishra, B. Manavathi
semanticscholar   +1 more source

Signaling through focal adhesion kinase

BioEssays, 1997
AbstractFocal adhesion kinase (FAK) is a nonreceptor protein‐tyrosine kinase implicated in controlling cellular responses to the engagement of cell‐surface integrins, including cell spreading and migration, survival and proliferation. Aberrant FAK signaling may contribute to the process of cell transformation by certain oncoproteins, including v‐Src ...
S K, Hanks, T R, Polte
openaire   +2 more sources

Focal adhesion kinase: in command and control of cell motility

Nature reviews. Molecular cell biology, 2005
S. Mitra, Daniel A. Hanson, D. Schlaepfer   +2 more
semanticscholar   +1 more source