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Focal adhesions – the cytoskeletal connection
Current Opinion in Cell Biology, 2000Cellular contacts with the extracellular matrix are regulated by the Rho family of GTPases through their effects on both the actin and the microtubule cytoarchitecture. Recent genetic, biochemical and structural data have highlighted the role played by a subset of actin-binding proteins in coupling integrins to cytoskeletal actin and in assembling ...
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Paxillin and focal adhesion signalling
Nature Cell Biology, 2000To facilitate a rapid response to environmental change, cells use scaffolding - or adaptor - proteins to recruit key components of their signal-transduction machinery to specific subcellular locations. Paxillin is a multi-domain adaptor found at the interface between the plasma membrane and the actin cytoskeleton.
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Focal Adhesion Kinase in Neuritogenesis
2007The transduction of extracellular signals through adhesion and guidance receptors into cytoskeleton reorganization underlies axon outgrowth and pathfinding decisions. The cytoplasmic protein tyrosine kinase focal adhesion kinase (FAK), a central regulator of cell motility phenomena during morphogenesis, is highly expressed in the developing nervous ...
Bonanomi D., Valtorta F.
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
exaly
pp125FAK in the Focal Adhesion
1996Integrins are a large superfamily of transmembrane adhesion molecules. In many types of cultured cells, integrins are concentrated in specialized sites called focal adhesions. Integrins are capable of transducing signals to the inside of the cell, which can effect cell migration, differentiation and growth, but the signaling mechanism of integrins has ...
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