Results 91 to 100 of about 51,195 (186)

Bioengineering models of cell signaling [PDF]

, 2000
Strategies for rationally manipulating cell behavior in cell-based technologies and molecular therapeutics and understanding effects of environmental agents on physiological systems may be derived from a mechanistic understanding of underlying signaling ...
Asthagiri, Anand R., Lauffenburger, Douglas A.   +1 more
core   +1 more source

PAKing up to the endothelium [PDF]

, 2009
Angiogenesis recapitulates the growth of blood vessels that progressively expand and remodel into a highly organized and stereotyped vascular network. During adulthood, endothelial cells that formed the vascular wall retain their plasticity and can be ...
Armelle Le Guelte, Eva Maria, Galan Moya, Julie Gavard   +3 more
core   +6 more sources

Resistance of HNSCC cell models to pan-FGFR inhibition depends on the EMT phenotype associating with clinical outcome

Molecular Cancer
Background Focal adhesion signaling involving receptor tyrosine kinases (RTK) and integrins co-controls cancer cell survival and therapy resistance. However, co-dependencies between these receptors and therapeutically exploitable vulnerabilities remain ...
Felix Broghammer, Irina Korovina, Mahesh Gouda, Martina Celotti, Johan van Es, Inga Lange, Cornelia Brunner, Jovan Mircetic, Robert P. Coppes, Olivier Gires, Andreas Dahl, Michael Seifert, Nils Cordes   +12 more
doaj   +1 more source

Preliminary study of the homeostatic regulation of osseointegration by nanotube topology

Materials Today Bio
The ideal implant surface plays a substantial role in maintaining bone homeostasis by simultaneously promoting osteoblast differentiation and limiting overactive osteoclast activity to a certain extent, which leads to satisfactory dynamic ...
Tao Chen, MingXing Ren, YuZhou Li, Zheng Jing, XinXin Xu, FengYi Liu, DingQiang Mo, WenXue Zhang, Jie Zeng, He Zhang, Ping Ji, Sheng Yang   +11 more
doaj   +1 more source

Generation of a competing endogenous RNA network and validation of BNIP1 expression in the lung of irradiated mice

Translational Oncology
Background: Radiation-induced lung injury (RILI) is a serious complication of radiation therapy, and it is mediated by long non-coding RNAs (lncRNAs).
Qing-hua Yu, Shu-yan Duan, Xue-kun Xing, Xin-ming Fan, Nan Zhang, Gui-yuan Song, Yong-jian Hu, Fei Wang, Tian-zhu Chao, Li-tao Wang, Ping Xu   +10 more
doaj   +1 more source

Cyclic strain promotes shuttling of PYK2/Hic-5 complex from focal contacts in osteoblast-like cells.

, 2006
International audienceWe showed that cyclic strain (CS) of osteoblastic cells induced tyrosine phosphorylation of two homologous tyrosine kinases FAK and PYK2, and of two homologous adaptor proteins paxillin and Hic5, with similar kinetics ...
Boutahar, Nadia, Guignandon, Alain, Lafage-Proust, Marie-Hélène, Rattner, Aline, Vico, Laurence   +4 more
core   +4 more sources

Distinct ligand binding sites in integrin alpha3beta1 regulate matrix adhesion and cell-cell contact. [PDF]

, 2003
The integrin alpha3beta1 mediates cellular adhesion to the matrix ligand laminin-5. A second integrin ligand, the urokinase receptor (uPAR), associates with alpha3beta1 via a surface loop within the alpha3 beta-propeller (residues 242-246) but outside ...
Chapman, Harold A, Ching, Tsui-Ting, Kreidberg, Jordan A, Kugler, Matthias C, Tom, Clifford C, Wei, Ying, Zhang, Feng   +6 more
core  

The mechanism of L1 cell adhesion molecule interacting with protein tyrosine kinase 2 to regulate the focal adhesion kinase–growth factor receptor-bound protein 2–son of sevenless–rat sarcoma pathway in the identification and treatment of type I high-risk endometrial cancer

Cytojournal
Objective: The objective of this study was to investigate how L1 cell adhesion molecule (L1CAM) interacting with protein tyrosine kinase 2 (PTK2) affects endometrial cancer (EC) progression and determine its association with the focal adhesion kinase (FAK)–growth factor receptor-bound protein 2 (GRB2)–son of sevenless (SOS)–rat sarcoma (RAS) pathway ...
He, Wei, Liu, Wei, Liu, Xiumei, Tan, Wenhua   +3 more
openaire   +2 more sources

Regulation of T cell receptor- and CD28-induced tyrosine phosphorylation of the focal adhesion tyrosine kinases Pyk2 and Fak by protein kinase C. A role for protein tyrosine phosphatases.

The Journal of biological chemistry, 2000
The T cell receptor (TCR)-CD3 complex and the costimulatory molecule CD28 are critical for T cell function. Both receptors utilize protein tyrosine kinases (PTKs) for the phosphorylation of various signaling molecules, a process that is critical for the function of both receptors.
M, Tsuchida, E R, Manthei, T, Alam, S J, Knechtle, M M, Hamawy   +4 more
openaire   +1 more source

Affinity modulation of platelet integrin alphaIIbbeta3 by beta3-endonexin, a selective binding partner of the beta3 integrin cytoplasmic tail. [PDF]

, 1997
Platelet agonists increase the affinity state of integrin alphaIIbbeta3, a prerequisite for fibrinogen binding and platelet aggregation. This process may be triggered by a regulatory molecule(s) that binds to the integrin cytoplasmic tails, causing a ...
Davis, KA, Eigenthaler, M, Ginsberg, MH, Kashiwagi, H, Schwartz, MA, Shattil, SJ   +5 more
core