Results 111 to 120 of about 66,236 (336)

Deciphering the Role of Cancer Stem Cells in Breast Cancer Brain Colonization Using a Novel Patient‐Derived Model

Advanced Healthcare Materials, EarlyView.
This study shows that stem‐like cells isolated from breast cancer brain metastases drive the spread and growth of tumors in the brain. Among them, a highly adhesive subgroup initiates metastasis and resists many drugs. By closely reflecting patient tumors, these models help identify new targets and improve the development of effective treatments ...
Stefania Faletti, Cristina Richichi, Daniela Osti, Elena Ceccacci, Giovanni Bertalot, Camilla Cerutti, Giuseppina Giardina, Adriana Marinaro, Brunella Costanza, Valentina Gambino, Elena Zaccheroni, Daniela Tosoni, Maria G. Filippone, Marcello Del Corvo, Yinxiu Zhan, Teresa Gravina, Davide Corà, Monica Patanè, Bianca Pollo, Maria Giovanna Jodice, Salvatore Pece, Babette B. Weksler, Ignacio A. Romero, Pierre‐Olivier Couraud, Elisabetta Munzone, Massimiliano Del Bene, Francesco DiMeco, Giuliana Pelicci   +27 more
wiley   +1 more source

Tyrosine kinase inhibition produces specific alterations in axon guidance in the grasshopper embryo [PDF]

, 1998
Tyrosine kinase signaling pathways are essential for process outgrowth and guidance during nervous system development. We have examined the roles of tyrosine kinase activity in programming growth cone guidance decisions in an intact nervous system in ...
Menon, Kaushiki P., Zinn, Kai
core  

Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF [PDF]

, 1999
Secretion of inflammatory products from neutrophils can be induced by a combination of signals from ligated integrins and receptors for soluble, physiological agonists such as TNF.
Michele Fuortes, Maxine Melchior, Hyunsil Han, Gholson J. Lyon, Carl Nathan, Nathan, Nathan, Nathan, Graham, Fuortes, Fuortes, Berton, Yan, Fernandez, Berton, Lowell, Yan, Schaller, Hanks, Fernandez, Lev, Sasaki, Avraham, Schaller, Zheng, Tokiwa, Shiloh, Jones, Loike, Hildebrand, Salgia, Hiregowdara, Li, Ganju, Ostergaard, Laudanna, Hanke, Lindberg, Ding, Jones, Klippel, Didichenko, Yan, Bilder   +43 more
core   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

The noni anthraquinone damnacanthal is a multi-kinase inhibitor with potent anti-angiogenic effects [PDF]

, 2017
Este es el manuscrito que fue aceptado y que finalmente se publicó en Cancer Letters con el DOI: 10.1016/j.canlet.2016.10.037The natural bioactive compound damnacanthal inhibits several tyrosine kinases.
García-Vilas, Javier A., Martínez-Poveda, Beatriz, Medina, Miguel Ángel, Pino-Ángeles, Almudena, Quesada, Ana R.   +4 more
core  

Plant‐Produced Viral Nanoparticles Decorated with Nanobodies Against HER2 Improve Retention and Recruitment of Immune Cells in Solid Tumors

Advanced Healthcare Materials, EarlyView.
Potato virus X is a filamentous RNA plant virus that can be engineered into a molecular tool for cancer therapy. We produced genetically‐encoded virus‐derived nanoparticles decorated with nanobodies targeting cancer cell receptors, epidermal growth factor receptor (EGFR) and human epidermal growth factor 2 (HER2).
Enrique Lozano‐Sanchez, Miguel A. Moreno‐Gonzalez, Fernando Merwaiss, Nicole F. Steinmetz, José‐Antonio Daròs   +4 more
wiley   +1 more source

Similarities and differences between the E5 oncoproteins of bovine papillomaviruses type 1 and type 4: Cytoskeleton, motility and invasiveness in E5-transformed bovine and mouse cells [PDF]

, 2006
Bovine papillomaviruses (BPVs) are oncogenic viruses. In cattle, BPV-1/2 is associated with urinary bladder cancer and BPV-4 with upper GI tract cancer. BPV E5 is a small hydrophobic protein localised in the endoplasmic reticulum (ER) and Golgi apparatus
Anderson, Araibi, Ashrafi, Ashrafi, Barbara Marchetti, Brad Ozanne, Burnett, Campo, Carragher, DiMaio, Emmanuella Tsirimonaki, Faccini, Fackler, Frame, Frame, Frame, Frame, G. Hossein Ashrafi, Geiger, Hennigan, Jackson, Jaggar, Jarrett, Kasper, Lu, Lynn McGarry, M. Saveria Campo, Marchetti, Nobes, Nunbhakdi-Craig, O’Brien, O’Brien, O’Brien, Pennie, Robina Ullah, Schapiro, Schiller, Scott, Suprynowicz, zur Hausen   +39 more
core   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Nuclear expression of Lyn, a Src family kinase member, is associated with poor prognosis in renal cancer patients [PDF]

, 2016
Background: 8000 cases of renal cancer are diagnosed each year in the UK, with a five-year survival rate of 50 %. Treatment options are limited; a potential therapeutic target is the Src family kinases (SFKs).
Aitchison, Michael, Edwards, Joanne, Fraser, Siobhan, Hammond, Rachel, Jones, Robert J., Lim, Zhi, MacDonald, Alasdair I., Oades, Grenville M., Qayyum, Tahir, Roseweir, Antonia K.   +9 more
core   +1 more source

Phosphorylation of RACK1 on Tyrosine 52 by c-Abl Is Required for Insulin-like Growth Factor I-mediated Regulation of Focal Adhesion Kinase*

Journal of Biological Chemistry, 2009
Focal Adhesion Kinase (FAK) activity is controlled by growth factors and adhesion signals in tumor cells. The scaffolding protein RACK1 (receptor for activated C kinases) integrates insulin-like growth factor I (IGF-I) and integrin signaling, but whether
P. Kiely, G. Baillie, R. Barrett, D. Buckley, D. Adams, M. Houslay, R. O’Connor   +6 more
semanticscholar   +1 more source