Results 91 to 100 of about 66,236 (336)

Regulation of integrin-mediated cellular responses through assembly of a CAS/Crk scaffold [PDF]

, 2004
The molecular coupling of CAS and Crk in response to integrin activation is an evolutionary conserved signaling module that controls cell proliferation, survival and migration.
Schwartz, Schlaepfer, Klemke, Takino, Cho, Takino, Reddien, Kain, Reddien, Gumienny, Miller, Feller, Feller, Kiyokawa, Mayer, Schlessinger, Pawson, Mayer, Prosser, Rosen, Donaldson, ten Hoeve, Songyang, Turner, Panetti, Schaller, Schaller, Bouton, Stupack, Sakai, Smit, Liu, Thien, Rao, Chin, Ota, Liu, Hibi, Casamassima, Gelkop, Coggeshall, March, Rohrschneider, Knudsen, Posern, Buensuceso, Gotoh, Tanaka, Kiyokawa, Nishihara, Feller, Feller, Ren, Smith, Van Etten, Nimnual, Schumacher, Confalonieri, Salcini, Mochizuki, Girardin, Smith, Galletta, Li, Arai, Law, Ishino, Alexandropoulos, Nakamoto, Law, Minegishi, Nakamoto, Polte, Vuori, Nojima, Cheresh, Cary, Hanks, Cary, Lakkakorpi, Astier, Garton, Liu, Li, Nakashima, Petch, Owen, Ruest, Sakai, Schlaepfer, Vuori, Fonseca, Goldberg, Garton, Mielenz, Gu, Manie, Kiyokawa, Grimsley, Wymann, Hawkins, Yokote, Ojaniemi, Casamassima, Liu, Kook, Van Etten, Raitano, Shishido, Plattner, Lamorte, Riordan, Kirsch, Schlaepfer, Prasad, Garcia-Guzman, Abassi, Ting, Hashimoto, Cho, Hamasaki, Kiosses, Brahmbhatt, Bailly, Chodniewicz, Chodniewicz, Bokel, Pendergast, Kruh, Wang, Woodring, Koleske, Lanier, Lewis, Lewis, Wang, Kain, Frasca, Lamorte, Chen, Wells, Renshaw, Zvara, Vuori, Dolfi, Woodring, Pellicena, Steller, Raff, Testaz, Barila, Sieg, Yuan, Gong, Fogerty, Kolibaba, Rhodes, Iwahara, Matsuda, Honda, van der Flier, Spencer, Bruce-Staskal, Goel   +163 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Ras-Related Protein Rab-32 and Thrombospondin 1 Confer Resistance to the EGFR Tyrosine Kinase Inhibitor Osimertinib by Activating Focal Adhesion Kinase in Non-Small Cell Lung Cancer [PDF]

, 2022
Zeinab Kosibaty, Odd Terje Brustugun, Inger Johanne Zwicky Eide, Georgios Tsakonas, Oscar Grundberg, Luigi De Petris, Marc McGowan, Per Hydbring, Simon Ekman   +8 more
openalex   +1 more source

Osteopontin inhibits osteoblast responsiveness through the down-regulation of focal adhesion kinase mediated by the induction of low–molecular weight protein tyrosine phosphatase

Molecular Biology of the Cell, 2017
Osteopontin (OPN) is an osteogenic marker protein. Osteoblast functions are affected by inflammatory cytokines and pathological conditions. OPN is highly expressed in bone lesions such as those in rheumatoid arthritis. However, local regulatory effects of OPN on osteoblasts remain ambiguous.
Kusuyama, Joji, Bandow, Kenjiro, Ohnishi, Tomokazu, Hisadome, Mitsuhiro, Shima, Kaori, Semba, Ichiro, Matsuguchi, Tetsuya   +6 more
openaire   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Targeting Btk/Etk of prostate cancer cells by a novel dual inhibitor. [PDF]

, 2014
Btk and Etk/BMX are Tec-family non-receptor tyrosine kinases. Btk has previously been reported to be expressed primarily in B cells and has an important role in immune responses and B-cell malignancies.
Bhardwaj, G, Changou, C, Chintapalli, S, Evans, CP, Guo, W, Kumaresan, P, Kung, H-J, Lam, KS, Liu, R, Ma, A-H, Mazloom, A, Patterson, R, Sanchez, E, Xiao, K, Xiao, W, Yang, JC, Yeh, C-T   +16 more
core   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

TGFβ activates c-Jun and Erk1 via αβ integrin [PDF]

, 2003
Transforming growth factor β (TGFβ) plays an important role in animal development and many cellular processes. A variety of cellular functions that are required for tumor metastasis are controlled by integrins, a family of cell adhesion receptors ...
Schmidt Christian, Luettich Karsta
core   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Depletion of Host Cell Focal Adhesion Kinase Increases the Susceptibility to Invasion by Trypanosoma cruzi Metacyclic Forms

Frontiers in Cellular and Infection Microbiology, 2019
Focal adhesion kinase (FAK), a cytoplasmic protein tyrosine kinase (PTK), is implicated in diverse cellular processes, including the regulation of F-actin dynamics.
Thiago Souza Onofre, João Paulo Ferreira Rodrigues, Nobuko Yoshida   +2 more
doaj   +1 more source