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Active Endothelial Inactivation of Hyperpermeability: The Role of Nitric Oxide-Driven cAMP/Epac1 Signaling. [PDF]
J Cardiovasc Dev DisLillo MA, Burboa PC, Durán WN.
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Focal adhesion kinase/Src family kinase axis-mediated tyrosine phosphorylation of metabolic enzymes facilitates tumor metastasis. [PDF]
Signal Transduct Target TherChen J +7 more
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From Adhesion to Invasion: Integrins, Focal Adhesion Signaling, and Actin Binding Proteins in Cervical Cancer Progression-A Scoping Review. [PDF]
CellsHałas-Wiśniewska M +3 more
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Focal adhesion kinase: an integrin-linked protein tyrosine kinase
Trends in Cell Biology, 1993Recent evidence has shown that binding of integrins to components of the extracellular matrix serves to initiate cellular signals, resulting in changes in cytoskeletal architecture and activation of intracellular signalling pathways. Here we review the evidence that protein tyrosine kinases, including focal-adhesion-associated kinases, play a central ...
M D, Schaller, J T, Parsons
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Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma
Cancer, 1999Focal adhesion kinase (FAK) is a tyrosine kinase that is important to such key functions such as cell adhesion, motility, and invasion. A MEDLINE search of the years 1980-1998 found no previous reports of FAK expression in human ovarian carcinoma. The authors performed experiments to determine whether FAK expression is elevated in this disease.Ten ...
P L, Judson +3 more
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Focal Adhesion Kinase–Related Protein Tyrosine Kinase Pyk2 in T-Cell Activation and Function
Immunologic Research, 2005Pyk2 is a protein tyrosine kinase expressed primarily in brain and hematopoietic cells. It becomes activated in response to stimulation through numerous receptors, including integrins, chemokine receptors, and antigen receptors, and is found in association with src-family kinases. Although this enzyme associates with many proteins known to be important
Hanne L, Ostergaard, Tara L, Lysechko
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Nature, 1992
Increasing evidence indicates that the integrin family of cell adhesion receptors can transduce biochemical signals from the extracellular matrix to the cell interior to modulate cell growth and differentiation. We have shown that integrin/ligand interactions can trigger tyrosine phosphorylation of a protein of M(r) 120,000 (pp120), so it is possible ...
J L, Guan, D, Shalloway
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Increasing evidence indicates that the integrin family of cell adhesion receptors can transduce biochemical signals from the extracellular matrix to the cell interior to modulate cell growth and differentiation. We have shown that integrin/ligand interactions can trigger tyrosine phosphorylation of a protein of M(r) 120,000 (pp120), so it is possible ...
J L, Guan, D, Shalloway
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Neuroscience Letters, 2000
Oligodendrocytes, the myelinating cells of the central nervous system, arise from a profilerating pool of motile progenitor cells. The proliferation and survival of these cells is dependent on signal transduction via several protein tyrosine kinases (PTKs) including receptors for fibroblast growth factor -2, the platelet-derived growth factor receptors
T J, Kilpatrick +4 more
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Oligodendrocytes, the myelinating cells of the central nervous system, arise from a profilerating pool of motile progenitor cells. The proliferation and survival of these cells is dependent on signal transduction via several protein tyrosine kinases (PTKs) including receptors for fibroblast growth factor -2, the platelet-derived growth factor receptors
T J, Kilpatrick +4 more
openaire +2 more sources