Results 71 to 80 of about 51,195 (186)

TGFβ activates c-Jun and Erk1 via αβ integrin [PDF]

, 2003
Transforming growth factor β (TGFβ) plays an important role in animal development and many cellular processes. A variety of cellular functions that are required for tumor metastasis are controlled by integrins, a family of cell adhesion receptors ...
Schmidt Christian, Luettich Karsta
core   +2 more sources

Osteopontin inhibits osteoblast responsiveness through the down-regulation of focal adhesion kinase mediated by the induction of low–molecular weight protein tyrosine phosphatase

Molecular Biology of the Cell, 2017
Osteopontin (OPN) is an osteogenic marker protein. Osteoblast functions are affected by inflammatory cytokines and pathological conditions. OPN is highly expressed in bone lesions such as those in rheumatoid arthritis. However, local regulatory effects of OPN on osteoblasts remain ambiguous.
Kusuyama, Joji, Bandow, Kenjiro, Ohnishi, Tomokazu, Hisadome, Mitsuhiro, Shima, Kaori, Semba, Ichiro, Matsuguchi, Tetsuya   +6 more
openaire   +2 more sources

Tyrosine kinase inhibition produces specific alterations in axon guidance in the grasshopper embryo [PDF]

, 1998
Tyrosine kinase signaling pathways are essential for process outgrowth and guidance during nervous system development. We have examined the roles of tyrosine kinase activity in programming growth cone guidance decisions in an intact nervous system in ...
Menon, Kaushiki P., Zinn, Kai
core  

A role for Syk-kinase in the control of the binding cycle of the β2 integrins (CD11/CD18) in human polymorphonuclear neutrophils [PDF]

, 2003
A fine control of β2 integrin (CD11/CD18)-mediated firm adhesion of human neutrophils to the endothelial cell monolayer is required to allow ordered emigration.
Arnaout, Arnaout, Bilsland, Bohnsack, Clark, Coxon, Danilenko, Diamond, Diamond, Dustin, El-Hillal, Fougerolles, Geahlen, Harder, Hjorth, Hynes, Kooyk, Kooyk, Krauss, Laemmli, Law, Lawson, Loike, Lu, Lub, Mocsai, Mocsai, Nathan, Ojaniemi, Olivier, Ota, Robinson, Simons, Smilenov, Springer, Tanaka, Vines, Walzog, Walzog, Walzog, Walzog, Willeke, Woodside, Wright, Wright, Yan, Yan, Zhang   +47 more
core   +1 more source

Identification of the protein kinases Pyk3 and Phg2 as regulators of the STATc-mediated response to hyperosmolarity [PDF]

, 2014
Cellular adaptation to changes in environmental osmolarity is crucial for cell survival. In Dictyostelium, STATc is a key regulator of the transcriptional response to hyperosmotic stress. Its phosphorylation and consequent activation is controlled by two
A Kortholt, A Kortholt, AA Noegel, Adrian John Harwood, BK Gilsbach, C Blanc, Christoph S. Clemen, CR Thompson, DE Levy, H Kiu, H Kuwayama, H Towbin, J Faix, J Langenick, J Na, Jeffrey G. Williams, Jianbo Na, JM Goldberg, K Adler, KL Williams, L Gebbie, Linh Hai Vu, Ludwig Eichinger, M Brink, M Fukuzawa, M Gamper, MR Lee, NS Lee, P Farbrother, P Gatsios, R Kang, RH Insall, T Araki, T Araki, T Araki, T Araki, Tsuyoshi Araki, UK Laemmli   +37 more
core   +5 more sources

Depletion of Host Cell Focal Adhesion Kinase Increases the Susceptibility to Invasion by Trypanosoma cruzi Metacyclic Forms

Frontiers in Cellular and Infection Microbiology, 2019
Focal adhesion kinase (FAK), a cytoplasmic protein tyrosine kinase (PTK), is implicated in diverse cellular processes, including the regulation of F-actin dynamics.
Thiago Souza Onofre, João Paulo Ferreira Rodrigues, Nobuko Yoshida   +2 more
doaj   +1 more source

Purification of Cortactin Using Anion Exchange Chromatography [PDF]

, 2014
Cortactin is an actin-binding protein that has been shown to be involved in cellular migration and metastases in cancer. Bacterially expressed and purified cortactin protein is often used in in vitro assays to examine cortactin’s role in promoting cell ...
Priester, Jacob
core   +1 more source

Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit gene [PDF]

, 2007
G protein-coupled receptor regulation of gene transcription primarily occurs through the phosphorylation of transcription factors by MAPKs. This requires transduction of an activating signal via scaffold proteins that can ultimately determine the outcome
Adam J. Pawson, Benard, Bonfil, Bonnerot, Brown, Brown, Brown, Burack, Call, Cao, Caroline Pope, Carpenter, Daub, David Bonfil, Davidson, Day, DeFea, Della Rocca, Dikic, Dimitra Karali, Dorn, Duan, Fincham, Fowkes, Grosse, Gutkind, Halvorson, Halvorson, Harris, Harris, Ikeda, Kaiser, Kraus, Kyriakis, Larder, Larder, Lee, Levi, Lindsay Davidson, Liu, Liu, Luttrell, Maudsley, McNeilly, Melamed, Millar, Mouillet, Mulvaney, Nancy Nelson, Naor, Naor, Pamela Brown, Pearson, Quirk, Quirk, Rachel Larder, Roberson, Robert P. Millar, Seger, Sevetson, Soltoff, Stuart Maudsley, Swirnoff, Thiel, Topilko, Tremblay, Turgeon, Whitmarsh, Windle, Wolfe, Yokoi, Yu, Zhang, Zvi Naor   +73 more
core   +1 more source

Focal adhesions are foci for tyrosine-based signal transduction via GIV/Girdin and G proteins. [PDF]

, 2015
GIV/Girdin is a multimodular signal transducer and a bona fide metastasis-related protein. As a guanidine exchange factor (GEF), GIV modulates signals initiated by growth factors (chemical signals) by activating the G protein Gαi.
Ghosh, Pradipta, Kabir, Firooz, Kalogriopoulos, Nicholas, Lo, I-Chung, Lopez-Sanchez, Inmaculada, Midde, Krishna K, Wang, Honghui   +6 more
core   +1 more source

Yersinia type III secretion : send in the effectors [PDF]

, 2002
Pathogenic Yersinia spp (Yersinia pestis, Yersinia pseudotuberculosis, and Yersinia enterocolitica) have evolved an exquisite method for delivering powerful effectors into cells of the host immune system where they inhibit signaling cascades and block ...
Cornelis, G. R.
core   +1 more source