Results 141 to 150 of about 50,276 (321)

Identification and immunophenotype of abnormal cells present in focal cortical dysplasia type IIb

Surgical and Experimental Pathology, 2018
Background Focal cortical dysplasias (FCDs) are malformations of cortical development that present cortical dyslamination and abnormal cell morphology and are frequently associated with refractory epilepsy.
Gleice K. Sousa, Caroline S. Capitelli, Thaís C. D. Dombroski, César A. B. Zanella, Vera C. Terra, Tonicarlo R. Velasco, Hélio R. Machado, João A. Assirati, Carlos G. Carlotti, Vani M. Alves, Jaderson Costa DaCosta, André L. Palmini, Eliseu Paglioli, Americo C. Sakamoto, Roberto Spreafico, Rita Garbelli, Luciano Neder, Antonio R. Martins   +17 more
doaj   +1 more source

Amygdala enlargement associated with remote epileptogenic lesions

Epilepsia, EarlyView.
Abstract Objective To determine the prevalence and possible causes of amygdala enlargement in patients with drug‐resistant temporal lobe epilepsy. Methods Patients were retrospectively identified via a radiology information system and a large language model.
Horst Urbach, Theo Demerath, Alexander Rau, Dirk‐Matthias Altenmüller, Marcel Heers, Samer Elsheikh   +5 more
wiley   +1 more source

Exploring pathways leading to drug‐resistant epilepsy for patients with cryptogenic new onset refractory status epilepticus

Epilepsia, EarlyView.
Abstract Objective Cryptogenic new onset refractory status epilepticus (cNORSE) carries high risks of long‐term disability and post‐NORSE epilepsy, but mechanisms remain unclear. We aimed to assess the predictive value of inflammatory and brain injury biomarkers and determine whether immune disturbances persist in the chronic phase. Methods We enrolled
Aurélie Hanin, Clémence Marois, Martin Guillemaud, Mario Chavez, Léa Cosme, Zineb Hayatou, Aurore Besnard, Gwen Goudard, Véronique Masson, Louis Cousyn, Margaux Cheval, Jérôme A. Denis, Rana Alkouri, Foudil Lamari, Francesca Bisulli, Krista Eschbach, Raquel Farias‐Moeller, Nicolas Gaspard, Elizabeth E. Gerard, Giada Giovannini, Teneille Gofton, Margaret T. Gopaul, Marissa Kellogg, Stefano Meletti, Lorenzo Muccioli, Elena Pasini, Olga Taraschenko, Nathan Torcida, Mark S. Wainwright, Ji Yeoun Yoo, Nora Wong, Dominique Bonnefont‐Rousselot, Sophie Demeret, Lawrence J. Hirsch, Vincent Navarro   +34 more
wiley   +1 more source

Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement

Nature Communications, 2016
The etiology of focal cortical dysplasia (FCD) is not fully understood. Here authors generate an mTORC1 overactivation mouse model that recapitulates hallmarks of type II FCDs, including spontaneous seizures, and suggest that neuronal defects, rather ...
Lawrence S. Hsieh, John H. Wen, Kumiko Claycomb, Yuegao Huang, Felicia A. Harrsch, Janice R. Naegele, Fahmeed Hyder, Gordon F. Buchanan, Angelique Bordey   +8 more
doaj   +1 more source

A case of posterior quadrant disconnection for post-subdural empyema epilepsy -focal cortical dysplasia might be the underlying cause of refractory epilepsy-

Interdisciplinary Neurosurgery, 2018
Introduction: Intracranial subdural empyema (ISDE) can cause drug-resistant epilepsy. We attempted to cure post-ISDE refractory epilepsy by operative surgery and assessed the neuropathological findings.
Yuya Sakakura, Ayataka Fujimoto, Tohru Okanishi, Yosuke Masuda, Mitsuyo Nishimura, Hideo Enoki   +5 more
doaj   +1 more source

Focal cortical dysplasia: pathophysiological approach

Child's Nervous System, 2006
Clinical and experimental studies on focal cortical dysplasia (FCD) were carried out.For the experimental study, an experimental FCD model of rats was developed. Twenty Wistar rats at 0-2 days after birth were used for the study. Kainic acid (KA) solution was injected stereotaxically into medial and lateral sites of the sensori-motor cortex.
Hodozuka, Akira, Tsuda, H, Hashizume, K, Tanaka, T   +3 more
openaire   +3 more sources

A star in the daylight clinical vignette: Lesional focal epilepsy with cerebral accessory falx

Epileptic Disorders, EarlyView.
Kyle McGrath, Joel Kaye, John Paul Sheehy, Heather Ravvin McKee   +3 more
wiley   +1 more source

Decoding epilepsy's molecular blueprint: Machine learning unravels transcriptomic subtypes and regulatory networks

Epilepsia, EarlyView.
Abstract Objective Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy. The molecular heterogeneity underlying DRE remains poorly defined, largely due to limited access to resected brain tissue and substantial genetic diversity.
Yanping Weng, Yu Ma, Wanwan Hou, Haibo Li, Yuanfeng Zhou, Rui Zhao, Hao Li, Lian Chen, Yangyang Ma, Li Jin, Yi Wang, Yu An   +11 more
wiley   +1 more source

Unstable slow oscillations couple with epileptogenic fast‐rhythm bistability in sleep‐related epilepsy: A stereoelectroencephalographic study

Epilepsia, EarlyView.
We examined the functional relationship between large‐scale δ‐band phase synchrony and local epileptogenic β–γ‐band amplitude bistability during NREM sleep. Increased synchrony and strong bistability characterized the epileptogenic zone, with strongest effects during N2 sleep, when seizures most frequently occur.
Gaia Burlando, Chiara Belforte, Felix Siebenhühner, Luca Di Tullio, Lorenzo Chiarella, Vladislav Myrov, Frédéric Zubler, Monica Roascio, Francesco Cardinale, Satu Palva, J. Matias Palva, Laura Tassi, Lino Nobili, Gabriele Arnulfo, Sheng H. Wang   +14 more
wiley   +1 more source

Epilepsy, Acquired Aphasia with Focal Cortical Dysplasia

Annals of Indian Academy of Neurology, 1999
A six year old boy having complex partial seizures with secondary generalization of four months duration developing isolated expressive dysphasia, later progressing to global aphasia is being reported.
Girija A.S, Somanath V
doaj