Results 121 to 130 of about 713,420 (262)

Multimodal modeling of the ictal onset zone in refractory insular epilepsy and seizure outcome of magnetic resonance‐guided laser interstitial therapy: A pediatric single‐center retrospective study

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to evaluate seizure outcomes after magnetic resonance‐guided laser interstitial thermal therapy (MRgLITT) in children with insular epilepsy and to assess how the extent of ablation overlaps with multimodal definitions of the ictal onset zone (IOZ).
Lelio Guida, Emma Losito, Sebastian Rodrigo, Catherine Chiron, Ludovic Fillon, Marie Bourgeois, Anna Kaminska, Johan Pallud, Nicole Chemaly, Volodia Dangouloff‐Ross, Stephane Auvin, Blandine Dozieres, Rima Nabbout, Olivier David, Nathalie Boddaert, Thomas Blauwblomme   +15 more
wiley   +1 more source

Dysembryoplastic neuroepithelial tumor (DNET) and focal cortical dysplasia: Case report of two pediatric patients with imaging features

, 2017
We describe the clinical course and imaging features from two children diagnosed with focal cortical dysplasia and dysembryoplastic neuroepithelial tumor.
Monwabisi Makola, Kim Maria Cecil
core   +1 more source

Transcriptomic analysis reveals distinct expression patterns in focal cortical dysplasia

Epilepsia, EarlyView.
Abstract Objective Focal cortical dysplasia (FCD) is a common cause of drug‐resistant epilepsy in children and adults and exhibits substantial clinical and histopathological heterogeneity. However, morphological classification alone does not fully explain variability in epileptogenicity, disease severity, or treatment response.
Shivani Sonawane, Michal Hendrych, Michaela Ručková, Robin Jugas, Jan Vrbský, Martin Pail, Barbora Straka, Martina Strnadová, Lenka Krsková, Adam Vácha, Miroslav Koblížek, Barbora Splítková, Kateřina Koželková, Eliška Hloušková, Tereza Vaňková, Josef Zámečník, Štefánia Aulická, Markéta Hermanová, Pavel Kršek, Ondřej Slabý, Milan Brázdil   +20 more
wiley   +1 more source

ILAE genetic literacy series: Focal cortical dysplasia

Focal cortical dysplasia (FCD) is a common cause of drug-resistant focal epilepsy in children and young adults and is often surgically remediable. The genetics of FCD are increasingly understood due to the ability to perform genomic testing including ...
Fakhfakh, F, Tsai, MH, Lerche, H, Esterhuizen, AI, Berkovic, SF, Mefford, HC, Lowenstein, DH, Helbig, I, Lopes-Cendes, I, Palmer, EE, Lesca, G, Tan, NCK, Delanty, N, Perucca, P, Macdonald-Laurs, E, McTague, A, Cross, JH, Leventer, RJ, Brunklaus, A   +18 more
core   +1 more source

Reasons for not reoperating and outcomes of reoperation after seizure recurrence in pediatric epilepsy surgery: A population‐based study

Epilepsia, EarlyView.
Abstract Objective Epilepsy surgery is an established and effective treatment for children with drug‐resistant epilepsy. Although the majority of patients become seizure‐free postoperatively, 20%–40% experience seizure recurrence. Although repeat surgery can achieve seizure freedom in selected cases, the reasons children with seizure recurrence do not ...
Vincent Zheng, Atte Karppinen, Eija Gaily, Päivi Koroknay‐Pál, Henri Lehtinen, Eeva‐Liisa Metsähonkala   +5 more
wiley   +1 more source

Cortical surface analysis for focal cortical dysplasia diagnosis by using PET images

Heliyon
Focal cortical dysplasia (FCD) is a neurological disorder distinguished by faulty brain cell structure and development. Repetitive and uncontrollable seizures may be linked to FCD's aberrant cortical thickness, gyrification, and sulcal depth ...
Eric Jacob Bacon, Chaoyang Jin, Dianning He, Shuaishuai Hu, Lanbo Wang, Han Li, Shouliang Qi   +6 more
doaj   +1 more source

Epilepsy syndromes classification

Epilepsia Open, EarlyView.
Abstract Epilepsy syndromes are distinct electroclinical entities which have been recently defined by the International League Against Epilepsy Nosology and Definitions Task Force. Each syndrome is associated with “a characteristic cluster of clinical and EEG features, often supported by specific etiologic findings”.
Elaine C. Wirrell, Nicola Specchio, Rima Nabbout, Phillip L. Pearl, Kate Riney   +4 more
wiley   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Electrophysiology of the focal cortical dysplasias [PDF]

Epilepsia, 2010
openaire   +2 more sources

The expression of astroglial glutamate transporters in patients with focal cortical dysplasia: an immunohistochemical study

, 2009
An abnormal increase in the extracellular glutamate is thought to play a crucial role in the initiation, spread, and maintenance of seizure activity.In normal conditions, the majority of this excess glutamate is cleared via glial glutamate transporters ...
Ulu, Mustafa Onur, ERASLAN, Berna Senel, Ozyurt, Emin, Biceroglu, Hueseyin, Uzan, Mustafa, Tanriverdi, Taner, Isler, Cihan, Ozkara, Cigdem, Oz, Buge, Cihan Isler, Buge Oz, Mustafa Onur Ulu, Hüseyin Biceroglu, Mustafa Uzan, Taner Tanriverdi, Berna Senel Eraslan, Cigdem Ozkara, Emin Ozyurt   +17 more
core   +1 more source