Results 91 to 100 of about 2,268,232 (304)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Performing focus groups: Unsettling 'blueprints'

open access: yes, 2004
This paper will explore the use of focus groups from two theoretical perspectives: poststructuralism and critical realism. The authors will bring together their understandings of these frameworks in the context of performing the focus group as a ...
Dwyer, Angela E., Christensen, Clare
core  

The use of 360-videos to bridge the gap between pre-clinical and clinical dental teaching

open access: yesBMC Medical Education
Background The transition from pre-clinical to clinical teaching is often a time of heightened anxiety for students. With the shift to bi-modal teaching during the pandemic there was an opportunity to explore the use of 360-degree videos and virtual ...
Nabeela Caratela   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Faculty Members Experience About Teaching of Medical Professionalism in Qazvin University of Medical Sciences [PDF]

open access: yesPizhūhish dar Āmūzish-i ̒ulūm-i Pizishkī, 2015
Introduction : Evidence suggests that unprofessional behavior is a common problem among medical students. The purpose of this study was to evaluate pre-conditions and barriers of establishment of professional medical education from perspective of faculty
A Allami, N mohammadi, M Shirazi
doaj  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

The focal group as a technique for data collection and analysis in qualitative research

open access: yesO Mundo da Saúde, 2011
The focal group constitutes an important technique for data collection in qualitative research. With the aim of extending its use and to constitute the participants as active subjects of nursing research, the present study aimed at examining the focal ...
Dirce Stein Backes   +3 more
doaj  

Virtual Focus Groups: New Frontiers in Research

open access: yesInternational Journal of Qualitative Methods, 2005
New information and communication technologies in the form of learning management systems provide unique and inventive opportunities for qualitative researchers.
Lyn Turney, Catherine Pocknee
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Influenza Pandemic Outbreaks: Conducting Focus Groups with Rural Communities in Baram, Sarawak

open access: yes, 2013
Our research aims to explore rural communities' understanding, awareness and attitude towards H1N1 Influenza pandemic outbreaks and prevention measures.
Wah, C.R.J, Mohd-Nor, Rohaya
core  

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