Results 81 to 90 of about 2,268,232 (304)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Older people as partners in assistive technology research: the use of focus groups in the design process

open access: yes, 2002
There is an increasing recognition that older people are capable of being critical and active consumers of assistive technologies. This has led to the proposition that older people should be involved in their design and evaluation.
Turner-Smith, A   +7 more
core  

Mass Media and Memory: The Communist GDR in Today’s Communicative Memory

open access: yesMedijske Studije, 2014
Using the example of the German Democratic Republic (GDR) the present study asks how mass media shape collective memory. How do reports in German media on the GDR affect communicative memory?
Michael Meyen, Senta Pfaff-Rüdiger
doaj  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Review: Michael Bloor, Jane Frankland, Michelle Thomas & Kate Robson (2001). Focus Groups in Social Research

open access: yesForum: Qualitative Social Research, 2002
This book is an introductory text that situates focus groups within the social science context and provides basic guidelines for preparing and conducting focus groups as well as analyzing the data.
Jacqueline M. Barnett
doaj  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Genetic information: Special or not? Responses from focus groups with members of a health maintenance organization.

open access: yes, 2007
http://dx.doi.org/10.1002/ajmg.a ...
Culver, Julie O.   +5 more
core   +1 more source

Focus groups: técnica de investigación cualitativa en investigación de mercados

open access: yesRevista de Ciencias Economicas, 2011
Los focus groups son utilizados en investigación de mercados como una herramienta de investigación cualitativa, por la posibilidad de interactuar con el grupo meta objeto de estudio, por lo que se puede conocer y entender de manera profunda las actitudes,
Carmen Isabel Ivankovich-Guillén   +1 more
doaj  

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