Results 31 to 40 of about 3,009 (130)

PGAP6, a GPI-specific phospholipase A2, has narrow substrate specificity against GPI-anchored proteins

Journal of Biological Chemistry, 2020
PGAP6, also known as TMEM8A, is a phospholipase A2 with specificity to glycosylphosphatidylinositol (GPI) and expressed on the surface of various cells. CRIPTO, a GPI-anchored co-receptor for a morphogenic factor Nodal, is a sensitive substrate of PGAP6.
Gun-Hee Lee, Morihisa Fujita, H. Nakanishi, H. Miyata, M. Ikawa, Y. Maeda, Y. Murakami, T. Kinoshita   +7 more
semanticscholar   +1 more source

The Significance of Mono‐ and Dual‐Effective Agents in the Development of New Antifungal Strategies

Chemical Biology &Drug Design, Volume 105, Issue 1, January 2025.
The future of treating challenging fungal infections lies in novel therapies targeting new antifungal targets, overcoming resistance mechanisms, and exploring innovative dual inhibitors. ABSTRACT Invasive fungal infections (IFIs) pose significant challenges in clinical settings, particularly due to their high morbidity and mortality rates.
Cengiz Zobi, Oztekin Algul
wiley   +1 more source

Brain Transcriptome Profiles of Greater Amberjack (Seriola dumerili) Juveniles Under Long‐Term Hypo‐ and Hypersaline Stress

Aquaculture Research, Volume 2025, Issue 1, 2025.
The fish brain plays a crucial role in regulating growth, reproduction, development, and adaptation to environmental stress. However, there are few studies that have examined the entire fish brain transcriptome and its responses to long‐term hypo‐ and hyper‐salinity stress. Greater amberjack (Seriola dumerili) has a high commercial value in mariculture
Xiaoying Ru, Yang Huang, Tong Zhou, Tonglin Yang, Peipei Chen, Jiahui Yang, Chunhua Zhu, Hongjuan Shi, Christyn Bailey   +8 more
wiley   +1 more source

Identification of Compound Heterozygous DPM1 Variants in a Pediatric Patient With Congenital Disorder of Glycosylation Type Ie

Case Reports in Pediatrics, Volume 2025, Issue 1, 2025.
Congenital disorders of glycosylation (CDG) constitute a group of rare genetic metabolic diseases caused by defects in the synthesis and modification of oligosaccharides. CDG‐Ie is a rare subtype caused by mutations in the DPM1 gene. We describe a female patient who presented with ocular abnormalities, motor retardation, hypotonia, hepatic dysfunction,
Wei Song, Wenzhi Zhou, Liu Yang, Li Tang, Nur Arslan   +4 more
wiley   +1 more source

The Arabidopsis GPI-Anchored LTPg5 Encoded by At3g22600 Has a Role in Resistance against a Diverse Range of Pathogens

International Journal of Molecular Sciences, 2020
Arabidopsis contains 34 genes for glycosylphosphatidylinositol (GPI)-anchored LTPg proteins. A motif analysis has placed these into four groups. With one exception, all are produced with a signal peptide and are most likely attached to the cell membrane ...
M. Ali, Amjad Abbas, Farrukh Azeem, M. Shahzadi, H. Bohlmann   +4 more
semanticscholar   +1 more source

Interferon Stimulated Gene Expression Is a Biomarker for Primary Mitochondrial Disease

Annals of Neurology, Volume 96, Issue 6, Page 1185-1200, December 2024.
Objective Mitochondria are implicated in regulation of the innate immune response. We hypothesized that abnormalities in interferon signaling may contribute to pathophysiology in patients with primary mitochondrial disease (PMD). Methods Expression of interferon stimulated genes (ISGs) was measured by real‐time polymerase chain reaction (PCR) in whole ...
Nandaki Keshavan, Lana Mhaldien, Kimberly Gilmour, Shamima Rahman   +3 more
wiley   +1 more source

Clinical glycoproteomics: methods and diseases

MedComm, Volume 5, Issue 10, October 2024.
An overview of clinical glycoproteomics: methods and diseases. The primary types of glycosylations include N‐glycosylation and O‐glycosylation. Three main glycoproteomic strategies are employed, with the bottom‐up approach being the most commonly utilized.
Yujia Wang, Kaixin Lei, Lijun Zhao, Yong Zhang   +3 more
wiley   +1 more source

Bifidobacterium longum BL‐19 inhibits oxidative stress and inflammatory damage in the liver of mice with NAFLD by regulating the production of butyrate in the intestine

Food Science &Nutrition, Volume 12, Issue 9, Page 6442-6460, September 2024.
Bifidobacterium longum BL‐19 shows promise as an adjunct therapy for NAFLD, as it can significantly improve oxidative stress, reduce inflammation in the liver, and decrease lipid accumulation. Furthermore, B. longum BL‐19 enhances the production of butyric acid in the mouse gut.
Xiajun Zhang, Jingwen Xu, Xueyun Dong, Jiajun Tang, Yan Xie, Jie Yang, Limin Zou, Liang Wu, Jilong Fan   +8 more
wiley   +1 more source

Advancements and Perspectives in Folate‐Based Anticancer Drugs: Bridging Quantum and Classical Mechanics in Folate Receptor Research

Advanced Theory and Simulations, Volume 7, Issue 8, August 2024.
This review highlights the role of quantum and molecular mechanics in developing folate‐based anticancer drugs. Overexpressed in cancer cells, folate receptors (FRs) are key targets for drug delivery. A 10‐year survey shows that structural modifications enhance binding affinities and specificity.
Andrea Jess Josiah, Krishna Kuben Govender, Penny Poomani Govender, Suprakas Sinha Ray   +3 more
wiley   +1 more source

LORELEI-LIKE GPI-ANCHORED PROTEINS 2/3 regulate pollen tube growth as chaperones and coreceptors for ANXUR/BUPS receptor kinases in Arabidopsis.

Molecular Plant, 2019
Pollen tube growth is crucial for successful fertilization. In Arabidopsis thaliana, the ANXUR (ANX)/BUPS receptor kinase complex controls and maintains pollen tube growth in response to autocrine RAPID ALKALINIZATION FACTOR4/19 (RALF4/19) signaling ...
Hanqian Feng, Chen Liu, Rong Fu, Minmin Zhang, Hui Li, Lianping Shen, Qiqi Wei, Xiang Sun, Lin Xu, Bin Ni, Chao Li   +10 more
semanticscholar   +1 more source