Results 101 to 110 of about 15,553 (277)

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

Folates provoke cellular efflux and drug resistance of substrates of the multidrug resistance protein 1 (MRP1) [PDF]

, 2014
Cellular folate concentration was earlier reported to be a critical factor in the activity and expression of the multidrug resistance protein MRP1 (ABCC1).
Hooijberg, J.H., Jansen, G. (Gert), Kaspers, G.J.L. (Gertjan), Kathmann, I. (Ietje), Laan, A.C. (A.), Peters, G.J. (Godefridus), Pieters, R. (Rob), Zantwijk, I. (Ina) van   +7 more
core   +4 more sources

Patient Perspectives on Psychiatric Polygenic Risk Scores in Reproductive Decision‐Making and Polygenic Embryo Screening

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Polygenic risk scores (PRS) estimate individuals' genetic risk for developing multifactorial conditions. Recent genome‐wide association studies have enabled development of psychiatric PRS, which hold potential to streamline diagnosis and treatment of psychiatric conditions.
Lauren A. Ginn, Amanda R. Merner, Page M. Trotter, Kaitlynn P. Craig, Abigail C. Martinez, Ana Lucía Battaglino, Dorit Barlevy, Daphne M. Ayton, Takahiro Soda, Eric A. Storch, Gabriel Lázaro‐Muñoz, Stacey Pereira   +11 more
wiley   +1 more source

Overview of neural tube defects: history, folate-homocysteine cycle, MTHFR C677T polymorphism and preventions

Journal of Pediatric and Neonatal Individualized Medicine
Neural tube defects (NTDs) are common significant congenital malformations caused by very early disruptions in the development of the brain and spinal cord.
Kaouther Nasri
doaj   +1 more source

Dietary folates and cancer risk in a network of case-control studies [PDF]

, 2017
Background Folate deficiency leads to DNA damage and inadequate repair, caused by a decreased synthesis of thymidylate and purines. We analyzed the relationship between dietary folate intake and the risk of several cancers. Patients and methods The study
Dal Maso, L., Franceschi, S., La Vecchia, C., Levi, F., Malerba, S., Montella, M., Pelucchi, C., Serraino, D., Tavani, A., Zambon, A., Zucchetto, A.   +10 more
core  

Cytosolic Phosphoenoylpyruvate Carboxykinase Deficiency: Clinical, Biochemical, and Genetic Features of Five Non‐Finnish Patients

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Cytosolic phosphoenoylpyruvate carboxykinase (PEPCK‐C) is an essential, rate‐limiting enzyme in the gluconeogenesis pathway. PEPCK‐C deficiency presents with hypoglycaemia, hyperlactataemia and hepatopathy, and was first reported in association with bi‐allelic PCK1 variants in 2014.
Isaac Bernhardt, Polona Le Quesne Stabej, Claire Hart, Mark De Hora, Sarah Hulley, Mark Anderson, Harry G. Leitch, Hugh Lemonde, Bryony Ryder, James Davison   +9 more
wiley   +1 more source

The nexus of vitamin homeostasis and DNA synthesis and modification in mammalian brain [PDF]

, 2014
The purpose of this review is to discuss the implications of the 2009 discovery of the sixth deoxyribonucleoside (dN) [5-hydroxymethyldeoxycytidine (hmdC)] in DNA which is the most abundant in neurons.
Conrad E Johanson, Reynold Spector
core   +1 more source

Mucin Glycoprotein Nanoparticles Enable a Selective Antisense Therapy for Oncogenic MicroRNAs

Advanced NanoBiomed Research, EarlyView.
Mucin glycoproteins are turned into nanoparticles by employing synthetic DNA strands, which have a dual function: they stabilize the nanoparticles and act as binding sites for intracellular miRNA‐21. Thus, upon internalization into tumor cells, these mucin nanoparticles can deplete miRNA‐21 from the cytosol, which induces apoptosis in vitro and in vivo.
Ceren Kimna, Thomas Mayer, Di Zhang, Matthias Marczynski, Carolin A. Rickert, Fabio Henkel, Lennart J. K. Weiss, Friedrich C. Simmel, Yuxia Luan, Oliver Lieleg   +9 more
wiley   +1 more source

Pathogenesis of Secondary Anemia [PDF]

, 1971
In patients with tissue damage of a malignant, infectious, inflammatory, ischemic or surgical nature, the plasma elimination (PE) of folates, iron, albumin, and cholesterol appears to be increased.
Reizenstein, Peter
core   +1 more source

Synergism of Saccharum officinarum and Ananas comosus extract additives on the quality of electroplated zinc on mild steel. [PDF]

, 2013
Synergism of Saccharum officinarum (sugarcane) and Ananas comosus (pineapple) extract additives on the quality of electroplated zinc on mild steel in acid chloride solution was investigated experimentally at ambient temperature (*28 C).
Loto, C. A.
core   +1 more source