Results 51 to 60 of about 15,553 (277)

Dynamics of antifolate transport via the reduced folate carrier and the membrane folate receptor in murine leukaemia cells in vitro and in vivo [PDF]

, 2008
Murine L1210 leukaemia cells expressing either the reduced folate carrier (RFC) or the membrane folate receptor (MFR) were studied in vitro and in vivo to assess the dynamics of membrane transport of two categories antifolates; folate-based ...
Comijn, Elizabeth, Jansen, Gerrit, Kathmann, Ietje, Mauritz, Robert, Noordhuis, Paul, Peters, Godefridus, Pinedo, Herbert, Teshale, Habte   +7 more
core   +1 more source

MPI‐Guided Photothermal Therapy of Prostate Cancer Using Stem Cell Delivery of Magnetotheranostic Nanoflowers

Advanced Functional Materials, EarlyView.
Tumor‐tropic human mesenchymal stem cells (hMSCs) were used as delivery vehicles for magnetotheranostic gold–iron oxide nanoflowers. Magnetic particle imaging of the iron component demonstrated widespread intratumoral distribution and sustained retention in contrast to injection of naked nanoflowers.
Behnaz Ghaemi, Ana Rosu, Shreyas Kuddannaya, Gautier Laurent, Rana Bazzi, Stéphane Roux, Ali Shakeri‐Zadeh, Jeff W. M. Bulte   +7 more
wiley   +1 more source

SLC19A1 transports immunoreactive cyclic dinucleotides. [PDF]

, 2019
The accumulation of DNA in the cytosol serves as a key immunostimulatory signal associated with infections, cancer and genomic damage1,2. Cytosolic DNA triggers immune responses by activating the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon ...
Corn, Jacob E, Garelis, Nick E, Gowen, Benjamin G, Katibah, George E, Luteijn, Rutger D, McWhirter, Sarah M, Onia, Liberty, Raulet, David H, Woodward, Joshua J, Wyman, Stacia K, Zaver, Shivam A   +10 more
core  

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Health-Promoting Nutrients and Potential Bioaccessibility of Breads Enriched with Fresh Kale and Spinach

Foods, 2022
Bread is a staple food and can be a potential product to be enriched with various deficient nutrients. The objective of the study was to characterize the nutritional properties of toasted bread enriched with 10% and 20% of kale and wholemeal bread with ...
Marta Czarnowska-Kujawska, Małgorzata Starowicz, Veronika Barišić, Wojciech Kujawski   +3 more
doaj   +1 more source

Effect of nitrous oxide on folate coenzyme distribution and de novo synthesis of thymidylate in human bone marrow cells [PDF]

, 1992
The effect of nitrous oxide on intracellular folate metabolism of the human bone marrow was studied in vitro. Bone marrow cells, obtained from healthy volunteers, were incubated with 5 × 10−8m-[3H]5-formyltetrahydrofolate (5-formylTHF) for 18 hr to label
Abels, J. (Lyanne), Ermens, A.A.M. (Anton), Lindemans, J. (Jan), Schoester, M. (Martijn)   +3 more
core   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

Folate polyglutamylation is required for rice seed development [PDF]

, 2010
In plants, polyglutamylated folate forms account for a significant proportion of the total folate pool. Polyglutamylated folate forms are produced by the enzyme folylpolyglutamate synthetase (FPGS).
A Wingler, AD Hanson, AD Hanson, Anahi Santoyo Castelazo, Anne Diévart, B Gambonnet, B Shane, BA Moffatt, BF Lin, BF Lin, CR Somerville, D Heineke, David A. Barrett, Delphine Mieulet, E Cossins, Emmanuel Guiderdoni, G Orsomando, GJ Basset, GJ Basset, GJ Basset, Gregory Tucker, H Bauwe, H Imeson, Helen Parker, I Hayashi, JR Suh, K Gallardo, KR Lowe, L Chen, L DeSouza, LC Garratt, Malcolm J. Bennett, ML Jones, Nadège Lanau, Nampeung Anukul, O Galivan, PA Counce, Payam Mehrshahi, R Díaz de la Garza, Riza Abilgos Ramos, S Jabrin, S Ravanel, S Ravanel, S Storozhenko, V Besson, X Sun, Y Wang   +46 more
core   +2 more sources

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Next-Generation Sequencing for Whole-Genome Characterization of Weissella cibaria UTNGt21O Strain Originated From Wild Solanum quitoense Lam. Fruits: An Atlas of Metabolites With Biotechnological Significance

Frontiers in Microbiology, 2021
The whole genome of Weissella cibaria strain UTNGt21O isolated from wild fruits of Solanum quitoense (naranjilla) shrub was sequenced and annotated. The similarity proportions based on the genus level, as a result of the best hits for the entire contig ...
Gabriela N. Tenea, Pamela Hurtado
doaj   +1 more source