Results 71 to 80 of about 232,357 (217)
AlphaFold distillation for inverse protein design
Scientific ReportsInverse protein folding, the process of designing sequences that fold into a specific 3D structure, is crucial in bio-engineering and drug discovery. Traditional methods rely on experimentally resolved structures, but these cover only a small fraction of
Igor Melnyk +3 more
doaj +1 more source
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
Mechanism of DNA origami folding elucidated by mesoscopic simulations
Nature CommunicationsMany experimental and computational efforts have sought to understand DNA origami folding, but the time and length scales of this process pose significant challenges.
Marcello DeLuca +6 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Theoretical modelling of impact performance and parameter sensitivity analysis of folding wing
Acta Scientiarum: TechnologyReliable deployment and locking are critical for folding wings used in high-speed aircraft. However, the high-intensity impact occurring during deployment poses a significant challenge to the locking accuracy. This paper presents a theoretical model for
Haizhong Huang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Research on the motion characteristics of the opening process of double joint folding wings
AIP AdvancesThe folding wing mechanism is a system developed for the miniaturization of missile wings to facilitate box (cylinder) storage, transportation, and launching, saving the storage and transportation space of the missile and improving the combat capability ...
Tiegang Lv, Xiaowen Zhang, Qiao Junfu
doaj +1 more source
IEEE AccessFlapping-wing robots (FWRs) are highly sensitive to atmospheric gusts due to their low mass and strong aerodynamic coupling. One way to address this challenge is through active wing folding inspired by natural flyers.
Saddam Hussain Abbasi +3 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source