Results 71 to 80 of about 10,115,388 (315)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Mechanism-based corrector combination restores ΔF508-CFTR folding and function. [PDF]

, 2013
The most common cystic fibrosis mutation, Delta F508 in nucleotide binding domain 1 (NBD1), impairs cystic fibrosis transmembrane conductance regulator (CFTR)-coupled domain folding, plasma membrane expression, function and stability. VX-809, a promising
Okiyoneda, T., Beekman, Jeffrey, Verkman, Alan, Soya, N., Bagdany, Miklos, Dekkers, J. F., Kurth, Mark, Lukacs, Gergely, Veit, G., Veit, Guido, Beekman, Jeffrey M., Hegedűs, Tamás, Soya, Naoto, Bagdany, M., Lukacs, Gergely L., Dekkers, Johanna, Xu, Haijin, Okiyoneda, Tsukasa, Verkman, Alan S., Simon, Ágnes, Roldan, Ariel, Dekkers, Johanna F.   +21 more
core   +1 more source

Amnion formation in the mouse embryo: the single amniochorionic fold model [PDF]

BMC Developmental Biology, 2011
Abstract Background Despite the detailed knowledge obtained over the last decade on the molecular regulation of gastrulation in amniotes, the process of amnion development has been poorly described and illustrated in mice, and conflicting descriptions exist.
Pereira, Paulo N.G., Dobreva, Mariya, Graham, Liz, Huylebroeck, Danny, Lawson, Kirstie A., Zwijsen, An   +5 more
openaire   +3 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Single-molecule fluorescence studies of Protein Folding and Molecular Chaperones [PDF]

, 2011
Folding of newly synthesized proteins is an essential part of protein biosynthesis and misfolding can result in protein aggregation which can also lead to several severe diseases.
Sikor, Martin
core  

Relative domain folding and stability of a membrane transport protein [PDF]

, 2014
There is a limited understanding of the folding of multidomain membrane proteins. Lactose permease (LacY) of Escherichia coli is an archetypal member of the major facilitator superfamily of membrane transport proteins, which contain two domains of six ...
Findlay, Heather E., Findlay, Heather E, Harris, Nicola J., Booth, Paula J., Harris, Nicola J, Booth, Paula J, Simms, John, Liu, Xia, Harris, Nicola J; id_orcid   +8 more
core   +1 more source

Research on the Nonlinear Structural Dynamic Characteristics of the Rigid Flexible Coupling Folding Wing Model for Aircraft

Engineered Science
During the working process of the folding wing, there is not only a large-range rigid body motion but also a deformation motion of the flexible components. The problem of the rigid-flexible coupling of the structure is extremely complex.
Xinqiang Lu, Rui Yang, Shiyong Sun
doaj   +1 more source

Folding models for elastic and inelastic scattering [PDF]

, 2005
The most widely used models are the optical model potential (OMP) for elastic scattering, and its generalization to non-spherical shapes, the deformed optical model potential (DOMP) for inelastic scattering. These models are simple and phenomenological; their parameters are adjusted so as to reproduce empirical data. Nonetheless, there are certain, not
openaire   +1 more source