Results 91 to 100 of about 10,115,388 (315)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Specification and implementation of a parametricoperator: Folding [PDF]
, 2008 In the early stage of creation, the architect tests his working hypotheses by making many adjustments while designing. During the sketching phase, the existing modelling tools are not compatible with the iterative nature of this process. So the challenge
J.P. Wetzel, J.C. Bignon, S. Belblidia
core
Folding Patterns in Protein Sequences [PDF]
, 2007 A thesis submitted to the University of Manchester for the degree of Doctor of Philosophy in the Faculty of Engineering and Physical Sciences. School of Computer Science (2007).
Corpas, M., Manuel Corpas (97270)
core +1 more source
Flutter Characteristics of a Modified Z-Shaped Folding Wing Using a New Non-Intrusive Model
AerospaceUnmanned aerial vehicles (UAVs) with folding wings can serve in multiple mission profiles, usually accompanied by sudden changes in flight speed. These bring great challenges to the aeroelastic design of UAVs, especially in the calculation of flutter ...
Wuchao Qi, Shimiao Wu, Sumei Tian
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Proteome-Wide Analyis of Chaperonin-Dependent Protein Folding in Escherichia coli [PDF]
, 2006 In Escherichia coli, the cylindrical chaperonin GroEL and its cofactor GroES promote the folding of a fraction of newly synthesized polypeptide chains by acting as an Anfinsen cage.
Maier, T., Maier, Tobias
core
, 1980 Recent studies of the relationship between protein sequence and protein structure are reviewed. A detailed discussion of past attempts to predict the structure of a protein from its amino acid sequence, the protein folding problem, is presented and the ...
Cohen, Fred E.
core +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
The dominant folding route minimizes backbone distortion in SH3.
PLoS Computational Biology, 2012 Energetic frustration in protein folding is minimized by evolution to create a smooth and robust energy landscape. As a result the geometry of the native structure provides key constraints that shape protein folding mechanisms.
Heiko Lammert +2 more
doaj +1 more source